| URN | urn:agi-llid:1242 |
|---|---|
| Total Entities | 0 |
| Connectivity | 407 |
| Name | Gper1 |
| Description | G protein-coupled estrogen receptor 1 |
| Notes | This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq] |
| Ariadne Ontology | GPCR-GqCR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | drug binding |
|---|---|
| hormone binding | |
| steroid binding | |
| steroid hormone receptor activity | |
| G-protein coupled receptor activity | |
| signal transducer activity |
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| Golgi apparatus |
| GO Biological Process | positive regulation of phosphatidylinositol 3-kinase cascade |
|---|---|
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| signal transduction | |
| steroid hormone mediated signaling pathway | |
| intracellular steroid hormone receptor signaling pathway | |
| G-protein coupled receptor signaling pathway |
| Pathway | estrogen signaling pathway |
|---|---|
| bisphenol A response pathway |
| Group | GPCR-GqCR |
|---|---|
| positive regulation of phosphatidylinositol 3-kinase cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| signal transduction | |
| steroid hormone mediated signaling pathway | |
| intracellular steroid hormone receptor signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| drug binding | |
| hormone binding | |
| steroid binding | |
| steroid hormone receptor activity | |
| G-protein coupled receptor activity | |
| signal transducer activity | |
| membrane | |
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1242 |
|---|
| Hugo ID | 4485 |
|---|
| Human chromosome position | 7p22.3 |
|---|
| LocusLink ID | 1242 |
|---|---|
| 2852 | |
| 76854 | |
| 171104 |
| Alias | CEPR |
|---|---|
| DRY12 | |
| FEG-1 | |
| GPR30 | |
| LERGU | |
| LyGPR | |
| CMKRL2 | |
| LERGU2 | |
| GPCR-Br | |
| G-protein coupled estrogen receptor 1 | |
| mER | |
| heptahelix receptor | |
| chemokine receptor-like 2 | |
| IL8-related receptor DRY12 | |
| membrane estrogen receptor | |
| G protein-coupled receptor 30 | |
| G-protein coupled receptor 30 | |
| chemoattractant receptor-like 2 | |
| leucine rich protein in GPR30 3'UTR | |
| lymphocyte-derived G-protein coupled receptor | |
| constitutively expressed peptide-like receptor | |
| flow-induced endothelial G-protein coupled receptor 1 | |
| Gper | |
| Ceprl | |
| 6330420K13Rik | |
| G protein-coupled estrogen receptor 1 | |
| constitutively expressed peptide-like receptor like | |
| GPR41 | |
| G-protein coupled receptor 41 | |
| interleukin IL8-related receptor DRY12 | |
| interleukin IL8-related receptor | |
| IL8-related receptor | |
| Gq-mER | |
| OTTHUMP00000115502 | |
| leucine rich protein in gpr30 3'utr (lergu) | |
| MGC99678 | |
| OTTHUMP00000200079 | |
| OTTMUSP00000023577 | |
| MGC7035 | |
| membrane oestrogen receptor | |
| Flow-induced endothelial G protein-coupled receptors | |
| GPCR-BRs | |
| 6330420K13 | |
| BC003323 | |
| cDNA sequence BC003323 | |
| Chemokine receptor-like II | |
| G protein-coupled receptor GPR30 | |
| G protein-coupled estrogen receptor | |
| Flow-induced endothelial G protein-coupled receptor | |
| FEG I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601805 |
|---|
| Unigene ID | Hs.20961 |
|---|---|
| Mm.389706 | |
| Rn.9806 |
| KEGG ID | hsa:2852 |
|---|---|
| mmu:76854 | |
| rno:171104 |
| Swiss-Prot Accession | Q63ZY2 |
|---|---|
| Q99527 | |
| Q8BMP4 | |
| O08878 | |
| B2RRW0 | |
| Q9D392 | |
| A8K6C5 | |
| B5BUJ1 | |
| O00143 | |
| O43494 | |
| Q13631 | |
| Q6FHL1 | |
| Q96F42 | |
| Q99981 | |
| Q6FHU6 | |
| Q7Z7A7 | |
| Q7Z7A8 | |
| Q7Z7A9 |
| GO ID | 0004930 |
|---|---|
| 0042562 | |
| 0005496 | |
| 0003707 | |
| 0007186 | |
| 0030518 | |
| 0070374 | |
| 0045742 | |
| 0000139 | |
| 0005789 | |
| 0005887 | |
| 0005886 | |
| 0004871 | |
| 0007165 | |
| 0043401 | |
| 0005794 | |
| 0005783 | |
| 0016021 | |
| 0016020 | |
| 0008144 | |
| 0014068 | |
| 0004872 |
| PIR ID | G02670 |
|---|---|
| JC5069 | |
| JC5509 |
| Swiss-Prot ID | GPER_MOUSE |
|---|---|
| GPER_HUMAN | |
| GPER_RAT | |
| B2RRW0_MOUSE | |
| Q63ZY2_HUMAN | |
| A8K6C5_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Golgi apparatus membrane | |
| Plasma membrane |
| IPI ID | IPI00387226 |
|---|---|
| IPI00016025 | |
| IPI00196618 | |
| IPI00943374 | |
| IPI00470558 | |
| IPI00385515 | |
| IPI00915010 | |
| IPI00893076 |
| Mouse chromosome position | 5 |
|---|
| Rat chromosome position | 12q11 |
|---|
| Homologene ID | 15855 |
|---|
| MGI ID | 1924104 |
|---|
| RGD ID | 619845 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|