| URN | urn:agi-llid:2100 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1609 |
| Name | Esr2 |
| Description | estrogen receptor 2 (ER beta) |
| Notes | This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq] |
| Ariadne Ontology | Estrogen-like |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | lipid binding |
|---|---|
| hormone binding | |
| enzyme binding | |
| receptor antagonist activity | |
| steroid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter sequence-specific DNA binding | |
| estrogen response element binding | |
| metal ion binding | |
| zinc ion binding | |
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity | |
| ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| steroid hormone receptor activity | |
| estrogen receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| nucleoplasm | |
| plasma membrane | |
| perikaryon | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| nucleus | |
| neuron projection |
| GO Biological Process | epithelial cell maturation involved in prostate gland development |
|---|---|
| Sertoli cell proliferation | |
| cell-cell signaling | |
| extracellular negative regulation of signal transduction | |
| negative regulation of androgen receptor signaling pathway | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| signal transduction | |
| regulation of cell proliferation | |
| steroid hormone mediated signaling pathway | |
| intracellular steroid hormone receptor signaling pathway | |
| intracellular estrogen receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of cell death | |
| negative regulation of cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of neuron death | |
| positive regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| neuron migration | |
| cellular response to estradiol stimulus | |
| response to testosterone stimulus | |
| response to estradiol stimulus | |
| behavioral fear response | |
| negative regulation of behavior | |
| learning or memory | |
| prostate gland epithelium morphogenesis | |
| uterus development | |
| vagina development | |
| brain development | |
| ovarian follicle development | |
| gene expression |
| Pathway | PRL-GHR/STAT Expression Targets |
|---|---|
| PRL-PRLR Expression Targets | |
| IGF1/STAT Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| EGF/CTNN Expression Targets | |
| estrogen signaling pathway | |
| tamoxifen pharmacodynamics pathway | |
| bisphenol A response pathway |
| Group | Estrogen-like |
|---|---|
| epithelial cell maturation involved in prostate gland development | |
| Sertoli cell proliferation | |
| cell-cell signaling | |
| extracellular negative regulation of signal transduction | |
| negative regulation of androgen receptor signaling pathway | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| signal transduction | |
| regulation of cell proliferation | |
| steroid hormone mediated signaling pathway | |
| intracellular steroid hormone receptor signaling pathway | |
| intracellular estrogen receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of cell death | |
| negative regulation of cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of neuron death | |
| positive regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| neuron migration | |
| cellular response to estradiol stimulus | |
| response to testosterone stimulus | |
| response to estradiol stimulus | |
| behavioral fear response | |
| negative regulation of behavior | |
| learning or memory | |
| prostate gland epithelium morphogenesis | |
| uterus development | |
| vagina development | |
| brain development | |
| ovarian follicle development | |
| gene expression | |
| lipid binding | |
| hormone binding | |
| enzyme binding | |
| receptor antagonist activity | |
| steroid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter sequence-specific DNA binding | |
| estrogen response element binding | |
| metal ion binding | |
| zinc ion binding | |
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity | |
| ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| steroid hormone receptor activity | |
| estrogen receptor activity | |
| extracellular region | |
| nucleoplasm | |
| plasma membrane | |
| perikaryon | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| nucleus | |
| neuron projection | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 2100 |
|---|
| Hugo ID | 3468 |
|---|
| Human chromosome position | 14q23.2 |
|---|
| LocusLink ID | 2100 |
|---|---|
| 13983 | |
| 25149 |
| Alias | Erb |
|---|---|
| ESRB | |
| ESTRB | |
| NR3A2 | |
| ER-BETA | |
| ESR-BETA | |
| estrogen receptor beta | |
| estrogen receptor beta 4 | |
| estrogen nuclear receptor beta variant a | |
| estrogen nuclear receptor beta variant b | |
| nuclear receptor subfamily 3 group A member 2 | |
| ER[b] | |
| ERbeta | |
| ER beta | |
| oestrogen receptor beta | |
| Erb2 | |
| estrogen receptor 2 beta | |
| oestrogen receptor II | |
| mERbeta | |
| membrane ERbeta | |
| LOC440183 | |
| membrane estrogen receptor beta | |
| membrane-bound ERbeta | |
| membrane-bound estrogen receptor beta | |
| OTTMUSP00000023324 | |
| mER-beta | |
| oestrogen receptor 2 | |
| oestrogen receptor 2 (beta) | |
| OTTMUSP00000023299 | |
| estrogen receptor 2 (ER beta) | |
| oestrogen receptor 2 (er beta) | |
| 5 P 152 | |
| estrogen receptor II | |
| 5P(152) | |
| 5P-152 | |
| Esr2 | |
| ESR2_HUMAN | |
| estradiol receptor beta | |
| estrogen receptor 2 | |
| estrogen receptor 2 (beta) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601663 |
|---|
| Unigene ID | Hs.660607 |
|---|---|
| Hs.734038 | |
| Mm.2561 | |
| Rn.37460 | |
| Hs.525392 |
| KEGG ID | hsa:2100 |
|---|---|
| mmu:13983 | |
| rno:25149 |
| Swiss-Prot Accession | F1D8N3 |
|---|---|
| Q92731 | |
| Q7LCB3 | |
| O08537 | |
| Q62986 | |
| A8K8K5 | |
| O60608 | |
| O60685 | |
| O60702 | |
| O60703 | |
| O75583 | |
| O75584 | |
| Q0MWT5 | |
| Q0MWT6 | |
| Q86Z31 | |
| Q9UEV6 | |
| Q9UHD3 | |
| Q9UQK9 | |
| O35784 | |
| O35785 | |
| O55015 | |
| O55016 | |
| O70195 | |
| Q9R185 | |
| B2RUC6 | |
| E9QKX7 | |
| O35635 | |
| O70519 | |
| Q8BG65 | |
| Q91Z86 | |
| Q0PTK2 | |
| Q59F41 | |
| Q86U33 | |
| Q9JM97 | |
| Q59IV8 | |
| Q59IV9 |
| GO ID | 0003677 |
|---|---|
| 0001046 | |
| 0019899 | |
| 0030284 | |
| 0034056 | |
| 0004879 | |
| 0048019 | |
| 0003700 | |
| 0005496 | |
| 0003707 | |
| 0003713 | |
| 0008270 | |
| 0007420 | |
| 0007267 | |
| 0060743 | |
| 1900116 | |
| 0010467 | |
| 0030520 | |
| 0060766 | |
| 0030308 | |
| 0050680 | |
| 0000122 | |
| 0001764 | |
| 0001541 | |
| 0043065 | |
| 0051091 | |
| 0060740 | |
| 0006355 | |
| 0007165 | |
| 0006367 | |
| 0060065 | |
| 0060068 | |
| 0005576 | |
| 0005739 | |
| 0005654 | |
| 0005634 | |
| 0042562 | |
| 0008289 | |
| 0046872 | |
| 0043565 | |
| 0060011 | |
| 0001662 | |
| 0071392 | |
| 0030518 | |
| 0007611 | |
| 0048521 | |
| 0060548 | |
| 0008285 | |
| 1901215 | |
| 0070374 | |
| 0045742 | |
| 0045944 | |
| 0045893 | |
| 0042127 | |
| 0032355 | |
| 0033574 | |
| 0043401 | |
| 0006351 | |
| 0005737 | |
| 0043005 | |
| 0043204 | |
| 0048471 | |
| 0005886 | |
| 0043523 | |
| 0045885 | |
| 0043526 | |
| 0043193 | |
| 0004872 | |
| 0045449 | |
| 0006350 | |
| 0030528 |
| PIR ID | JC5939 |
|---|---|
| PW0044 | |
| S71400 | |
| JW0046 |
| Swiss-Prot ID | ESR2_HUMAN |
|---|---|
| ESR2_RAT | |
| ESR2_MOUSE | |
| Q7LCB3_HUMAN | |
| B2RUC6_MOUSE | |
| Q8BG65_MOUSE | |
| A8K8K5_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00023212 |
|---|---|
| IPI00218153 | |
| IPI00218155 | |
| IPI00218156 | |
| IPI00218157 | |
| IPI00218158 | |
| IPI00218159 | |
| IPI00397583 | |
| IPI00231793 | |
| IPI00231794 | |
| IPI00231795 | |
| IPI00231871 | |
| IPI00566569 | |
| IPI00114349 | |
| IPI00230298 | |
| IPI00230299 | |
| IPI00230300 | |
| IPI00410734 | |
| IPI00384140 | |
| IPI00231792 | |
| IPI00568681 | |
| IPI00565586 | |
| IPI00560961 |
| Mouse chromosome position | 12 33.0 cM |
|---|
| Rat chromosome position | 6q24 |
|---|
| Homologene ID | 1100 |
|---|
| MGI ID | 109392 |
|---|
| RGD ID | 2582 |
|---|
| Primary Cell Localization | Nucleus |
|---|