| URN | urn:agi-llid:2099 |
|---|---|
| Total Entities | 0 |
| Connectivity | 3165 |
| Name | Esr1 |
| Description | estrogen receptor 1 |
| Notes | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq] |
| Ariadne Ontology | Estrogen-like |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | lipid binding |
|---|---|
| hormone binding | |
| chromatin binding | |
| protein complex binding | |
| beta-catenin binding | |
| transcription factor binding | |
| enzyme binding | |
| type 1 metabotropic glutamate receptor binding | |
| steroid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter sequence-specific DNA binding | |
| estrogen response element binding | |
| metal ion binding | |
| zinc ion binding | |
| nitric-oxide synthase regulator activity | |
| sequence-specific DNA binding transcription factor activity | |
| ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| steroid hormone receptor activity | |
| estrogen receptor activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrial part | |
| chromatin remodeling complex | |
| nucleoplasm | |
| T-tubule | |
| integral to membrane | |
| protein complex | |
| plasma membrane | |
| perikaryon | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| Golgi apparatus | |
| nucleus | |
| terminal button | |
| neuron projection |
| GO Biological Process | cell growth |
|---|---|
| negative regulation of mitosis | |
| Sertoli cell proliferation | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of retinoic acid receptor signaling pathway | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| signal transduction | |
| intracellular receptor mediated signaling pathway | |
| steroid hormone mediated signaling pathway | |
| intracellular steroid hormone receptor signaling pathway | |
| intracellular estrogen receptor signaling pathway | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of neuron death | |
| positive regulation of fibroblast proliferation | |
| regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| osteoblast development | |
| epithelial cell development | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| androgen metabolic process | |
| cellular response to estrogen stimulus | |
| epithelial cell proliferation involved in mammary gland duct elongation | |
| response to estrogen stimulus | |
| response to estradiol stimulus | |
| negative regulation of gene expression | |
| regulation of branching involved in prostate gland morphogenesis | |
| positive regulation of nitric-oxide synthase activity | |
| mammary gland branching involved in pregnancy | |
| antral ovarian follicle growth | |
| uterus development | |
| vagina development | |
| male gonad development | |
| prostate epithelial cord elongation | |
| prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | |
| mammary gland alveolus development | |
| gene expression |
| Pathway | Tamoxifen-Induced Endometrium Cancer |
|---|---|
| WNT1 Expression Targets | |
| DLL1 Expression Targets | |
| DLL4 Expression Targets | |
| ADAM17 Expression Targets | |
| JAG1 Expression Targets | |
| IL2 Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| PRL-PRLR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| NRG1/Catenin Expression Targets | |
| NRG1/STAT Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/EP300/ETS/ETV/SP1 Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| OXT Expression Targets | |
| GNRH1 Expression Targets | |
| ADCYAP1 Expression Targets | |
| IGF1/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| INHBA-ACVR2/BMPR Expression Targets | |
| NOTCH Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| EGF/CTNN Expression Targets | |
| estrogen signaling pathway | |
| tamoxifen pharmacodynamics pathway | |
| bisphenol A response pathway |
| Group | Estrogen-like |
|---|---|
| cell growth | |
| negative regulation of mitosis | |
| Sertoli cell proliferation | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of retinoic acid receptor signaling pathway | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| signal transduction | |
| intracellular receptor mediated signaling pathway | |
| steroid hormone mediated signaling pathway | |
| intracellular steroid hormone receptor signaling pathway | |
| intracellular estrogen receptor signaling pathway | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of neuron death | |
| positive regulation of fibroblast proliferation | |
| regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| osteoblast development | |
| epithelial cell development | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| androgen metabolic process | |
| cellular response to estrogen stimulus | |
| epithelial cell proliferation involved in mammary gland duct elongation | |
| response to estrogen stimulus | |
| response to estradiol stimulus | |
| negative regulation of gene expression | |
| regulation of branching involved in prostate gland morphogenesis | |
| positive regulation of nitric-oxide synthase activity | |
| mammary gland branching involved in pregnancy | |
| antral ovarian follicle growth | |
| uterus development | |
| vagina development | |
| male gonad development | |
| prostate epithelial cord elongation | |
| prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | |
| mammary gland alveolus development | |
| gene expression | |
| lipid binding | |
| hormone binding | |
| chromatin binding | |
| protein complex binding | |
| beta-catenin binding | |
| transcription factor binding | |
| enzyme binding | |
| type 1 metabotropic glutamate receptor binding | |
| steroid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter sequence-specific DNA binding | |
| estrogen response element binding | |
| metal ion binding | |
| zinc ion binding | |
| nitric-oxide synthase regulator activity | |
| sequence-specific DNA binding transcription factor activity | |
| ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| steroid hormone receptor activity | |
| estrogen receptor activity | |
| membrane | |
| mitochondrial part | |
| chromatin remodeling complex | |
| nucleoplasm | |
| T-tubule | |
| integral to membrane | |
| protein complex | |
| plasma membrane | |
| perikaryon | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| Golgi apparatus | |
| nucleus | |
| terminal button | |
| neuron projection | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 2099 |
|---|
| Hugo ID | 3467 |
|---|
| Human chromosome position | 6q25.1 |
|---|
| LocusLink ID | 2099 |
|---|---|
| 13982 | |
| 24890 |
| Alias | ER |
|---|---|
| ESR | |
| Era | |
| ESRA | |
| NR3A1 | |
| RP1-130E4.1 | |
| estrogen receptor | |
| ER-alpha | |
| estradiol receptor | |
| estrogen nuclear receptor alpha | |
| estrogen receptor alpha E1-E2-1-2 | |
| estrogen receptor alpha E1-N2-E2-1-2 | |
| estrogen receptor alpha delta 4 +49 isoform | |
| nuclear receptor subfamily 3 group A member 1 | |
| estrogen receptor alpha 3*,4,5,6,7*/822 isoform | |
| estrogen receptor alpha delta 4*,5,6,7*/654 isoform | |
| estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform | |
| estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform | |
| estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform | |
| Estr | |
| ER[a] | |
| Estra | |
| ERalpha | |
| AA420328 | |
| AU041214 | |
| RNESTROR | |
| Er alpha | |
| estrogen receptor protein | |
| estrogen receptor 1 (alpha) | |
| estrogen receptor alpha variant delta 4 | |
| OTTHUMP00000017719 | |
| membrane ERalpha | |
| membrane-bound ERalpha | |
| membrane-bound estrogen receptor alpha | |
| mERalpha | |
| mER-alpha | |
| NR3A I | |
| estrogen receptor alpha variant U2 | |
| oestrogen receptor 1 | |
| oestrogen receptor 1 (alpha) | |
| oestrogen receptor alpha | |
| estrogen receptor alpha variant U1 | |
| OTTHUMP00000017718 | |
| estrogen receptor I | |
| OTTMUSP00000022868 | |
| OTTMUSP00000022869 | |
| OTTMUSP00000022870 | |
| oestrogen receptor I | |
| dj443c4.1.1 | |
| membrane estrogen receptor alpha | |
| dj443c4.1.1 (estrogen receptor 1) | |
| DKFZp686n23123 | |
| ESR I | |
| ESR1 | |
| estrogen receptor alpha | |
| estrogen receptor 1 | |
| estradiol receptor alpha | |
| ESR1_HUMAN |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 133430 |
|---|---|
| 157300 | |
| 608446 |
| Unigene ID | Hs.208124 |
|---|---|
| Mm.9213 | |
| Mm.463262 | |
| Mm.489063 | |
| Rn.10595 |
| KEGG ID | hsa:2099 |
|---|---|
| mmu:13982 | |
| rno:24890 |
| Swiss-Prot Accession | G4XH65 |
|---|---|
| P03372 | |
| Q9UBT1 | |
| E7FJU2 | |
| P19785 | |
| P06211 | |
| Q9JJT5 | |
| Q9QY51 | |
| Q9QY52 | |
| Q13511 | |
| Q14276 | |
| Q5T5H7 | |
| Q6MZQ9 | |
| Q9NU51 | |
| Q9UDZ7 | |
| Q9UIS7 | |
| A0A4R1 | |
| Q14267 | |
| Q14268 | |
| Q16405 | |
| Q5C8S5 | |
| Q9H1Z6 | |
| Q9H2M1 | |
| Q9H2M2 | |
| Q9UE35 | |
| Q9Y2W8 | |
| Q3UT58 | |
| Q3UWN0 | |
| Q6LAN9 |
| GO ID | 0008013 |
|---|---|
| 0003682 | |
| 0001046 | |
| 0019899 | |
| 0030284 | |
| 0034056 | |
| 0038052 | |
| 0042562 | |
| 0030235 | |
| 0032403 | |
| 0003700 | |
| 0005496 | |
| 0003707 | |
| 0008134 | |
| 0031798 | |
| 0008270 | |
| 0060011 | |
| 0008209 | |
| 0001547 | |
| 0071391 | |
| 0002064 | |
| 0060750 | |
| 0010467 | |
| 0030520 | |
| 0060749 | |
| 0060745 | |
| 0043124 | |
| 0010629 | |
| 0043433 | |
| 0002076 | |
| 0070374 | |
| 0045742 | |
| 0048146 | |
| 0045429 | |
| 0051000 | |
| 0048386 | |
| 0051091 | |
| 0045944 | |
| 0060527 | |
| 0060523 | |
| 0042981 | |
| 0060687 | |
| 0006355 | |
| 0032355 | |
| 0043627 | |
| 0007165 | |
| 0006367 | |
| 0006351 | |
| 0060065 | |
| 0060068 | |
| 0005794 | |
| 0030315 | |
| 0016585 | |
| 0016021 | |
| 0016020 | |
| 0044429 | |
| 0005654 | |
| 0005634 | |
| 0043204 | |
| 0048471 | |
| 0005886 | |
| 0043195 | |
| 0003677 | |
| 0004879 | |
| 0008289 | |
| 0046872 | |
| 0043565 | |
| 0016049 | |
| 0030522 | |
| 0030518 | |
| 0008584 | |
| 0045839 | |
| 1901215 | |
| 0043401 | |
| 0005737 | |
| 0043005 | |
| 0043234 | |
| 0043523 | |
| 0045885 | |
| 0043526 | |
| 0004872 | |
| 0030528 | |
| 0045449 | |
| 0006350 |
| PIR ID | A40061 |
|---|---|
| S64737 | |
| S07379 |
| Swiss-Prot ID | ESR1_MOUSE |
|---|---|
| ESR1_HUMAN | |
| ESR1_RAT | |
| Q9UBT1_HUMAN | |
| Q5T5H7_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Golgi apparatus | |
| Cell membrane |
| IPI ID | IPI00117980 |
|---|---|
| IPI00218352 | |
| IPI00294982 | |
| IPI00914643 | |
| IPI01018719 | |
| IPI00201392 | |
| IPI00879773 | |
| IPI00807600 | |
| IPI00910582 | |
| IPI00815884 | |
| IPI00877891 | |
| IPI00902535 | |
| IPI00878052 | |
| IPI00830553 |
| Mouse chromosome position | 10 12.0 cM |
|---|
| Rat chromosome position | 1q12 |
|---|
| Homologene ID | 47906 |
|---|
| MGI ID | 1352467 |
|---|
| RGD ID | 2581 |
|---|
| Primary Cell Localization | Nucleus |
|---|