| URN | urn:agi-llid:6582 |
|---|---|
| Total Entities | 0 |
| Connectivity | 194 |
| Name | Slc22a2 |
| Description | solute carrier family 22 (organic cation transporter), member 2 |
| Notes | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Organic anions transport |
|---|---|
| Other transport proteins | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | transporter activity |
|---|---|
| steroid binding | |
| transmembrane transporter activity | |
| ion transmembrane transporter activity | |
| organic cation transmembrane transporter activity | |
| quaternary ammonium group transmembrane transporter activity | |
| choline transmembrane transporter activity | |
| secondary active organic cation transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| basolateral plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane |
| GO Biological Process | transmembrane transport |
|---|---|
| synaptic transmission | |
| neurotransmitter secretion | |
| neurotransmitter biosynthetic process | |
| ion transmembrane transport | |
| drug transmembrane transport | |
| body fluid secretion | |
| transport | |
| ion transport | |
| cation transport | |
| histamine transport | |
| organic cation transport | |
| quaternary ammonium group transport | |
| choline transport | |
| small molecule metabolic process |
| Pathway | metformin pharmacokinetics pathway |
|---|---|
| cisplatin response pathway |
| Group | Organic anions transport |
|---|---|
| Other transport proteins | |
| transmembrane transport | |
| synaptic transmission | |
| neurotransmitter secretion | |
| neurotransmitter biosynthetic process | |
| ion transmembrane transport | |
| drug transmembrane transport | |
| body fluid secretion | |
| transport | |
| ion transport | |
| cation transport | |
| histamine transport | |
| organic cation transport | |
| quaternary ammonium group transport | |
| choline transport | |
| small molecule metabolic process | |
| transporter activity | |
| steroid binding | |
| transmembrane transporter activity | |
| ion transmembrane transporter activity | |
| organic cation transmembrane transporter activity | |
| quaternary ammonium group transmembrane transporter activity | |
| choline transmembrane transporter activity | |
| secondary active organic cation transmembrane transporter activity | |
| membrane | |
| basolateral plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 6582 |
|---|
| Hugo ID | 10966 |
|---|
| Human chromosome position | 6q25.3 |
|---|
| LocusLink ID | 6582 |
|---|---|
| 20518 | |
| 29503 |
| Alias | OCT2 |
|---|---|
| RP11-317M22.2 | |
| solute carrier family 22 member 2 | |
| organic cation transporter 2 | |
| Orct2 | |
| solute carrier family 22, member 2 | |
| OCT2r | |
| rOCT2 | |
| OTTHUMP00000017538 | |
| Slc22a2 | |
| solute carrier family 22 (organic cation transporter), member 2 | |
| solute carrier family 22 member 2 isoform b | |
| organic cation transporter II | |
| solute carrier family 22 member 2 isoform a | |
| organic cation transporter (oct2) | |
| MGC32628 | |
| MGC18339 | |
| hOCT2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602608 |
|---|
| Unigene ID | Hs.436385 |
|---|---|
| Mm.17322 | |
| Rn.10555 |
| KEGG ID | hsa:6582 |
|---|---|
| mmu:20518 | |
| rno:29503 |
| Swiss-Prot Accession | O15244 |
|---|---|
| O70577 | |
| Q9R0W2 | |
| Q8BWF6 | |
| Q8K4X8 | |
| P70485 | |
| P97558 | |
| Q5T7Q6 | |
| Q6PIQ8 | |
| Q8NG62 | |
| Q9NQB9 |
| GO ID | 0015101 |
|---|---|
| 0007589 | |
| 0006855 | |
| 0042136 | |
| 0007269 | |
| 0015695 | |
| 0044281 | |
| 0007268 | |
| 0055085 | |
| 0005887 | |
| 0016020 | |
| 0005886 | |
| 0015220 | |
| 0015075 | |
| 0015651 | |
| 0008513 | |
| 0005496 | |
| 0022857 | |
| 0005215 | |
| 0006812 | |
| 0015871 | |
| 0051608 | |
| 0034220 | |
| 0006811 | |
| 0015697 | |
| 0006810 | |
| 0016323 | |
| 0016021 |
| PIR ID | JC4884 |
|---|
| Swiss-Prot ID | S22A2_MOUSE |
|---|---|
| S22A2_RAT | |
| S22A2_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00119459 |
|---|---|
| IPI00885506 | |
| IPI00188881 | |
| IPI00017625 | |
| IPI00448803 | |
| IPI00885027 |
| Mouse chromosome position | 17 7.32 cM |
|---|
| Rat chromosome position | 1q11 |
|---|
| Homologene ID | 68293 |
|---|
| MGI ID | 1335072 |
|---|
| RGD ID | 61936 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|