| URN | urn:agi-llid:475 |
|---|---|
| Total Entities | 0 |
| Connectivity | 80 |
| Name | Atox1 |
| Description | ATX1 antioxidant protein 1 homolog (yeast) |
| Notes | This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Me++ homeostasis |
|---|
| GO Molecular Function | metallochaperone activity |
|---|---|
| copper-dependent protein binding | |
| metal ion binding | |
| copper ion binding | |
| copper chaperone activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | cellular copper ion homeostasis |
|---|---|
| response to oxidative stress | |
| transport | |
| ion transport | |
| metal ion transport | |
| copper ion transport |
| Pathway | cisplatin drug pathway |
|---|
| Group | Me++ homeostasis |
|---|---|
| cellular copper ion homeostasis | |
| response to oxidative stress | |
| transport | |
| ion transport | |
| metal ion transport | |
| copper ion transport | |
| metallochaperone activity | |
| copper-dependent protein binding | |
| metal ion binding | |
| copper ion binding | |
| copper chaperone activity | |
| cytosol |
| MedScan ID | 475 |
|---|
| Hugo ID | 798 |
|---|
| Human chromosome position | 5q32 |
|---|
| LocusLink ID | 475 |
|---|---|
| 11927 | |
| 84355 |
| Alias | ATX1 |
|---|---|
| HAH1 | |
| copper transport protein ATOX1 | |
| metal transport protein ATX1 | |
| AI256639 | |
| RP23-336J1.1 | |
| ATX1 homolog protein Rah1 | |
| ATX1 (antioxidant protein 1) homolog 1 | |
| Rah1 | |
| Copper transport protein ATOX I | |
| Metal transport protein ATX I | |
| MGC138453 | |
| OTTMUSP00000005867 | |
| HAH I | |
| MGC138455 | |
| Atox1 | |
| LOC193132 | |
| ATX1 antioxidant protein I | |
| Atox I | |
| ATX I | |
| ATX1 antioxidant protein 1 | |
| ATX1 (antioxidant protein 1) homolog 1 (yeast) | |
| ATX1 antioxidant protein 1 homolog (yeast) | |
| ATX1 antioxidant protein 1 homolog | |
| antioxidant 1 homolog |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602270 |
|---|
| Unigene ID | Hs.125213 |
|---|---|
| Mm.217759 | |
| Rn.11992 |
| KEGG ID | hsa:475 |
|---|---|
| mmu:11927 | |
| rno:84355 |
| Swiss-Prot Accession | O00244 |
|---|---|
| O08997 | |
| Q9WUC4 | |
| A8KAJ8 | |
| D3DQI2 | |
| Q2M1R6 | |
| Q56AP3 | |
| Q5NCU2 | |
| Q549B3 |
| EC Number | 6.2.1.2 |
|---|
| GO ID | 0016531 |
|---|---|
| 0005507 | |
| 0032767 | |
| 0016530 | |
| 0006878 | |
| 0006825 | |
| 0006979 | |
| 0005829 | |
| 0046872 | |
| 0006811 | |
| 0030001 | |
| 0006810 |
| PIR ID | JC7133 |
|---|
| Swiss-Prot ID | ATOX1_HUMAN |
|---|---|
| ATOX1_MOUSE | |
| ATOX1_RAT |
| Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00010863 |
|---|---|
| IPI00117379 | |
| IPI00203829 |
| Mouse chromosome position | 11 B1.3 |
|---|
| Rat chromosome position | 10q22 |
|---|
| Homologene ID | 2984 |
|---|
| MGI ID | 1333855 |
|---|
| RGD ID | 621684 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|