Elsevier Inc. uptaken_cisplatin --+> cisplatin response pathway Atp7b --+> decreased sensitivity/increased resistance Atp7b Atox1 ---- uptaken_cisplatin nucleotide excision repair pathway --+> decreased sensitivity/increased resistance Slc31a1 Atox1 uptaken_cisplatin ---> effluxed_cisplatin cisplatin DNA damage response pathway --+> nucleotide excision repair pathway DNA damage response pathway ---| DNA replication pathway aquated_cisplatin ---> cisplatin_DNA_adducts cisplatin_DNA_adducts --+> DNA damage response pathway nucleotide excision repair pathway ---| cisplatin_DNA_adducts Atox1 ---> Atp7b Atox1 ---> Atp7a Atp7a cisplatin_DNA_adducts ---| RNA polymerase II transcription pathway cisplatin_DNA_adducts ---- Pt-DNA adducts interactors cisplatin ---> uptaken_cisplatin Pt-DNA adducts interactors uptaken_cisplatin effluxed_cisplatin nucleotide excision repair pathway DNA replication pathway RNA polymerase II transcription pathway aquated_cisplatin DNA damage response pathway --+> intrinsic apoptotic pathway cisplatin_DNA_adducts ---| cancer cells cisplatin_DNA_adducts ---| non-small cell lung cancer pathway cisplatin_DNA_adducts cisplatin_DNA_adducts ---| colorectal cancer pathway colorectal cancer pathway cancer cells non-small cell lung cancer pathway cisplatin response pathway intrinsic apoptotic pathway DNA damage response pathway Atox1 --+> decreased sensitivity/increased resistance uptaken_cisplatin ---> aquated_cisplatin decreased sensitivity/increased resistance