Protein Gpr98

URN	urn:agi-llid:7400
Total Entities	0
Connectivity	42
Name	Gpr98
Description	G protein-coupled receptor 98
Notes	This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

Ariadne Ontology	GPCR-Other
	Secreted proteins

GO Molecular Function	myosin binding
	calcium ion binding
	transmembrane signaling receptor activity
	G-protein coupled receptor activity
	signal transducer activity

GO Cellular Component	membrane
	extracellular region
	integral to membrane
	stereocilia ankle link complex
	plasma membrane
	cell surface
	cytoplasm

GO Biological Process	response to stimulus
	cell communication
	signal transduction
	cell surface receptor signaling pathway
	G-protein coupled receptor signaling pathway
	neuropeptide signaling pathway
	maintenance of organ identity
	cell-cell adhesion
	inner ear receptor stereocilium organization
	detection of mechanical stimulus involved in sensory perception of sound
	multicellular organismal development
	inner ear development
	nervous system development
	neurological system process
	sensory perception of light stimulus
	visual perception
	sensory perception of sound
	photoreceptor cell maintenance

Pathway	auditory mechanotransduction pathway

Group	GPCR-Other
	response to stimulus
	cell communication
	signal transduction
	cell surface receptor signaling pathway
	G-protein coupled receptor signaling pathway
	neuropeptide signaling pathway
	maintenance of organ identity
	cell-cell adhesion
	inner ear receptor stereocilium organization
	detection of mechanical stimulus involved in sensory perception of sound
	multicellular organismal development
	inner ear development
	nervous system development
	neurological system process
	sensory perception of light stimulus
	visual perception
	sensory perception of sound
	photoreceptor cell maintenance
	myosin binding
	calcium ion binding
	transmembrane signaling receptor activity
	G-protein coupled receptor activity
	signal transducer activity
	membrane
	extracellular region
	integral to membrane
	stereocilia ankle link complex
	plasma membrane
	cell surface
	cytoplasm
	Secreted proteins

Hugo ID	17416

Human chromosome position	5q13

Alias	FEB4
	MASS1
	USH2B
	USH2C
	VLGR1
	VLGR1b
	G-protein coupled receptor 98
	usher syndrome type-2C protein
	very large G protein-coupled receptor 1
	very large G-protein coupled receptor 1
	monogenic, audiogenic seizure susceptibility 1 homolog
	monogenic audiogenic seizure susceptibility protein 1 homolog
	Mgr1
	Frings
	RP24-540A17.1
	neurepin
	monogenic, audiogenic seizure susceptibility 1
	monogenic audiogenic seizure susceptibility protein 1
	similar to very large G-protein coupled receptor 1
	G protein-coupled receptor 98
	very large G protein-coupled receptor I
	Usher syndrome 2B
	monogenic, audiogenic seizure susceptibility I
	monogenic, audiogenic seizure susceptibility 1 homolog (mouse)
	Usher syndrome 2B (autosomal recessive, mild)
	Usher syndrome 2C
	VLGR I
	monogenic, audiogenic seizure susceptibility
	Usher syndrome 2C (autosomal recessive)
	FEB-4
	MASS-1
	DKFZp761P0710
	FEB(4)
	febrile convulsions 4
	febrile convulsions IV
	LOC432787
	GPR98
	LOC380857
	LOC362068
	LOC116067
	KIAA0686
	RGD1562101
	LOC100362255

Unigene ID	Hs.591777
	Mm.288694

Swiss-Prot ID	GPR98_HUMAN

Cell Localization	Cell membrane
	Plasma membrane

Mouse chromosome position	13 40.0 cM

Rat chromosome position	2

Homologene ID	19815

MGI ID	1274784

RGD ID	1562101

Primary Cell Localization	Plasma membrane