| URN | urn:agi-llid:64944 |
|---|---|
| Total Entities | 0 |
| Connectivity | 46 |
| Name | Slc17a8 |
| Description | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 |
| Notes | This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Ariadne Ontology | Neurotransmitter loading |
|---|---|
| Cl- transport |
| GO Molecular Function | L-glutamate transmembrane transporter activity |
|---|---|
| symporter activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| synaptic vesicle membrane | |
| integral to membrane | |
| cytoplasmic vesicle | |
| neuron projection |
| GO Biological Process | transmembrane transport |
|---|---|
| amino acid transmembrane transport | |
| sensory perception of sound | |
| transport | |
| neurotransmitter transport | |
| ion transport | |
| sodium ion transport | |
| L-amino acid transport | |
| L-glutamate transport |
| Pathway | auditory mechanotransduction pathway |
|---|
| Group | Neurotransmitter loading |
|---|---|
| Cl- transport | |
| transmembrane transport | |
| amino acid transmembrane transport | |
| sensory perception of sound | |
| transport | |
| neurotransmitter transport | |
| ion transport | |
| sodium ion transport | |
| L-amino acid transport | |
| L-glutamate transport | |
| L-glutamate transmembrane transporter activity | |
| symporter activity | |
| cell junction | |
| membrane | |
| synapse | |
| synaptic vesicle membrane | |
| integral to membrane | |
| cytoplasmic vesicle | |
| neuron projection |
| MedScan ID | 64944 |
|---|
| Hugo ID | 20151 |
|---|
| Human chromosome position | 12q23.1 |
|---|
| LocusLink ID | 64944 |
|---|---|
| 246213 | |
| 216227 | |
| 266767 |
| Alias | DFNA25 |
|---|---|
| VGLUT3 | |
| vesicular glutamate transporter 3 | |
| solute carrier family 17 member 8 | |
| BC042593 | |
| vesicular glutamate transporter-3 | |
| SLC17A8 | |
| vesicular glutamate transporter III | |
| solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 | |
| OTTMUSP00000029420 | |
| deafness, autosomal dominant 25 | |
| OTTMUSP00000043239 | |
| cDNA sequence BC042593 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607557 |
|---|---|
| 605583 |
| Unigene ID | Hs.116871 |
|---|---|
| Mm.233921 | |
| Rn.84876 |
| KEGG ID | hsa:246213 |
|---|---|
| mmu:216227 | |
| rno:266767 |
| Swiss-Prot Accession | Q8NDX2 |
|---|---|
| Q8BFU8 | |
| Q7TSF2 | |
| B3KXZ6 | |
| B7ZKV4 | |
| Q17RQ8 | |
| Q8K1Q1 |
| GO ID | 0005313 |
|---|---|
| 0015293 | |
| 0006811 | |
| 0006836 | |
| 0007605 | |
| 0006814 | |
| 0055085 | |
| 0030054 | |
| 0016021 | |
| 0043005 | |
| 0030672 | |
| 0015807 | |
| 0015813 | |
| 0003333 | |
| 0006810 | |
| 0031410 | |
| 0016020 | |
| 0045202 |
| Swiss-Prot ID | VGLU3_HUMAN |
|---|---|
| VGLU3_MOUSE | |
| VGLU3_RAT |
| Cell Localization | Cytoplasmic vesicle |
|---|---|
| secretory vesicle | |
| synaptic vesicle membrane | |
| Membrane | |
| Cell junction | |
| synapse | |
| synaptosome | |
| Plasma membrane |
| IPI ID | IPI00168611 |
|---|---|
| IPI00783759 | |
| IPI00221470 | |
| IPI00200411 |
| Mouse chromosome position | 10 |
|---|
| Rat chromosome position | 7q13 |
|---|
| Homologene ID | 13584 |
|---|
| MGI ID | 3039629 |
|---|
| RGD ID | 628870 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|