| URN | urn:agi-llid:5358 |
|---|---|
| Total Entities | 0 |
| Connectivity | 34 |
| Name | Pls3 |
| Description | plastin 3 |
| Notes | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
| Ariadne Ontology | Actin-based cytoskeleton assembly |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | actin binding |
|---|---|
| calcium ion binding |
| GO Cellular Component | stereocilium |
|---|---|
| cytoplasm |
| GO Biological Process | auditory receptor cell differentiation |
|---|
| Pathway | auditory mechanotransduction pathway |
|---|
| Group | Actin-based cytoskeleton assembly |
|---|---|
| auditory receptor cell differentiation | |
| actin binding | |
| calcium ion binding | |
| stereocilium | |
| cytoplasm | |
| Biofluids assayable substances |
| MedScan ID | 5358 |
|---|
| Hugo ID | 9091 |
|---|
| Human chromosome position | Xq23 |
|---|
| LocusLink ID | 5358 |
|---|---|
| 102866 | |
| 81748 |
| Alias | T-plastin |
|---|---|
| plastin-3 | |
| T fimbrin | |
| T plastin | |
| AI115446 | |
| AL024105 | |
| T-fimbrin | |
| RP23-162M7.1 | |
| plastin 3, T | |
| plastin 3 (T-isoform) | |
| plastin 3 (T isoform) | |
| PLS3 | |
| OTTMUSP00000018963 | |
| T isoform plastin III | |
| plastin 3 | |
| T isoform plastin 3 | |
| OTTMUSP00000018966 | |
| OTTMUSP00000018964 | |
| OTTHUMP00000215746 | |
| LOC236867 | |
| OTTMUSP00000018965 | |
| OTTMUSP00000018967 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300131 |
|---|
| Unigene ID | Hs.496622 |
|---|---|
| Mm.28777 | |
| Rn.32103 |
| KEGG ID | hsa:5358 |
|---|---|
| mmu:102866 | |
| rno:81748 |
| Swiss-Prot Accession | P13797 |
|---|---|
| B4DPW9 | |
| Q3UJG9 | |
| Q99K51 | |
| Q3UKB1 | |
| Q562B2 | |
| Q63598 | |
| B1AX56 | |
| Q3TUZ5 | |
| A8K579 | |
| B1AQ09 | |
| Q86YI6 |
| GO ID | 0003779 |
|---|---|
| 0005509 | |
| 0005737 | |
| 0032420 | |
| 0042491 |
| PIR ID | A34789 |
|---|
| Swiss-Prot ID | PLST_MOUSE |
|---|---|
| PLST_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00115528 |
|---|---|
| IPI00216694 |
| Mouse chromosome position | X |
|---|
| Rat chromosome position | Xq14 |
|---|
| Homologene ID | 128200 |
|---|
| MGI ID | 104807 |
|---|
| RGD ID | 621409 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|