| URN | urn:agi-llid:8680 |
|---|---|
| Total Entities | 0 |
| Connectivity | 13 |
| Name | Ptprq |
| Description | protein tyrosine phosphatase, receptor type, Q |
| Notes | This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus are associated with hearing loss. [provided by RefSeq, Jan 2012] |
| Ariadne Ontology | Phosphatases |
|---|
| GO Molecular Function | hydrolase activity |
|---|---|
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane | |
| plasma membrane |
| GO Biological Process | regulation of fat cell differentiation |
|---|---|
| protein dephosphorylation | |
| peptidyl-tyrosine dephosphorylation | |
| dephosphorylation | |
| inner ear morphogenesis |
| Pathway | auditory mechanotransduction pathway |
|---|
| Group | Phosphatases |
|---|---|
| regulation of fat cell differentiation | |
| protein dephosphorylation | |
| peptidyl-tyrosine dephosphorylation | |
| dephosphorylation | |
| inner ear morphogenesis | |
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| membrane | |
| integral to membrane | |
| plasma membrane |
| MedScan ID | 8680 |
|---|
| Hugo ID | 9679 |
|---|
| Human chromosome position | 12q21.2 |
|---|
| LocusLink ID | 8680 |
|---|---|
| 374462 | |
| 237523 | |
| 360417 |
| Alias | DFNB84 |
|---|---|
| PTPGMC1 | |
| R-PTP-Q | |
| phosphotidylinositol phosphatase PTPRQ | |
| receptor-type tyrosine-protein phosphatase Q | |
| protein-tyrosine phosphatase, receptor-type, expressed by glomerular mesangial cells | |
| PTP-RQ | |
| rPTP-GMC1 | |
| glomerular mesangial cell receptor protein-tyrosine phosphatase | |
| protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1 | |
| PTPGMC I | |
| PTPRQ | |
| Protein-tyrosine phosphatase, receptor-type, expressed by glomerular | |
| protein tyrosine phosphatase, receptor type, Q | |
| LOC100129165 | |
| deafness, autosomal recessive 84 | |
| LOC338757 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603317 |
|---|---|
| 613391 |
| Unigene ID | Hs.539284 |
|---|---|
| Mm.391418 | |
| Rn.30011 |
| KEGG ID | hsa:374462 |
|---|---|
| mmu:237523 | |
| rno:360417 |
| Swiss-Prot Accession | Q9UMZ3 |
|---|---|
| P0C5E4 | |
| O88488 |
| EC Number | 3.1.3.48 |
|---|---|
| 3.1.3.- |
| GO ID | 0004725 |
|---|---|
| 0042472 | |
| 0045598 | |
| 0016021 | |
| 0016787 | |
| 0016791 | |
| 0004721 | |
| 0016311 | |
| 0006470 | |
| 0016020 | |
| 0005886 | |
| 0035335 |
| PIR ID | T14328 |
|---|
| Swiss-Prot ID | PTPRQ_RAT |
|---|---|
| PTPRQ_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Membrane | |
| Cytoplasm |
| IPI ID | IPI00209764 |
|---|---|
| IPI00674433 |
| Mouse chromosome position | 10 60.0 cM |
|---|
| Rat chromosome position | 7q21 |
|---|
| Homologene ID | 83557 |
|---|
| MGI ID | 1096349 |
|---|
| RGD ID | 620779 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|