| URN | urn:agi-llid:4652 |
|---|---|
| Total Entities | 0 |
| Connectivity | 20 |
| Name | Myo15a |
| Description | myosin XVA |
| Notes | This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Actomyosin based movement |
|---|
| GO Molecular Function | calmodulin binding |
|---|---|
| actin binding | |
| nucleotide binding | |
| ATP binding | |
| motor activity |
| GO Cellular Component | stereocilium |
|---|---|
| myosin complex | |
| cell projection | |
| cytoplasm | |
| stereocilium bundle | |
| cytoskeleton |
| GO Biological Process | locomotory behavior |
|---|---|
| inner ear morphogenesis | |
| sensory perception of sound |
| Pathway | auditory mechanotransduction pathway |
|---|
| Group | Actomyosin based movement |
|---|---|
| locomotory behavior | |
| inner ear morphogenesis | |
| sensory perception of sound | |
| calmodulin binding | |
| actin binding | |
| nucleotide binding | |
| ATP binding | |
| motor activity | |
| stereocilium | |
| myosin complex | |
| cell projection | |
| cytoplasm | |
| stereocilium bundle | |
| cytoskeleton |
| MedScan ID | 4652 |
|---|
| Hugo ID | 7594 |
|---|
| Human chromosome position | 17p11.2 |
|---|
| LocusLink ID | 4652 |
|---|---|
| 51168 | |
| 17910 | |
| 501699 |
| Alias | DFNB3 |
|---|---|
| MYO15 | |
| unconventional myosin-XV | |
| myosin-XV | |
| unconventional myosin-15 | |
| sh2 | |
| sh-2 | |
| Myo15a | |
| RP23-135F6.4 | |
| shaker 2 | |
| myosin XVA | |
| RGD1561873 | |
| myosin XV | |
| OTTMUSP00000005997 | |
| OTTMUSP00000008160 | |
| OTTMUSP00000019141 | |
| unconventional myosin XV | |
| DKFZp686n18198 | |
| shaker II | |
| FLJ31311 | |
| AA516932 | |
| Myosin XV (Unconventional myosin-15) | |
| FLJ17274 | |
| LOC216812 | |
| LOC217328 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602666 |
|---|---|
| 600316 |
| Unigene ID | Hs.462390 |
|---|---|
| Mm.89960 |
| KEGG ID | hsa:51168 |
|---|---|
| mmu:17910 | |
| rno:501699 |
| Swiss-Prot Accession | Q9UKN7 |
|---|---|
| Q9QZZ4 | |
| A2A637 | |
| A2A638 | |
| O70395 | |
| Q5SX93 | |
| Q7TMR5 | |
| Q7TMR6 | |
| Q9QWL6 |
| GO ID | 0005524 |
|---|---|
| 0003779 | |
| 0005516 | |
| 0003774 | |
| 0042472 | |
| 0007626 | |
| 0007605 | |
| 0005737 | |
| 0016459 | |
| 0032420 | |
| 0000166 | |
| 0042995 | |
| 0005856 | |
| 0032421 |
| PIR ID | A59295 |
|---|---|
| T42386 | |
| A59266 |
| Swiss-Prot ID | MYO15_MOUSE |
|---|---|
| MYO15_HUMAN |
| Cell Localization | Cell projection |
|---|---|
| stereocilium | |
| Cytoplasm | |
| cytoskeleton |
| IPI ID | IPI00467393 |
|---|---|
| IPI00776014 | |
| IPI00856671 | |
| IPI00152380 |
| Mouse chromosome position | 11 33.9 cM |
|---|
| Rat chromosome position | 10q22 |
|---|
| Homologene ID | 56504 |
|---|
| MGI ID | 1261811 |
|---|
| RGD ID | 1561873 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|