| URN | urn:agi-llid:71 |
|---|---|
| Total Entities | 0 |
| Connectivity | 115 |
| Name | Actg1 |
| Description | actin, gamma 1 |
| Notes | Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011] |
| Ariadne Ontology | Actomyosin based movement |
|---|---|
| Actin-based cytoskeleton assembly |
| GO Molecular Function | protein kinase binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| structural constituent of cytoskeleton |
| GO Cellular Component | costamere |
|---|---|
| filamentous actin | |
| cytoplasm | |
| cytosol | |
| myofibril | |
| cytoskeleton | |
| actin cytoskeleton | |
| axon |
| GO Biological Process | cellular component movement |
|---|---|
| axonogenesis | |
| sarcomere organization | |
| cell junction assembly | |
| cell-cell junction organization | |
| adherens junction organization | |
| response to calcium ion | |
| axon guidance | |
| blood coagulation |
| Pathway | auditory mechanotransduction pathway |
|---|
| Group | Actomyosin based movement |
|---|---|
| Actin-based cytoskeleton assembly | |
| cellular component movement | |
| axonogenesis | |
| sarcomere organization | |
| cell junction assembly | |
| cell-cell junction organization | |
| adherens junction organization | |
| response to calcium ion | |
| axon guidance | |
| blood coagulation | |
| protein kinase binding | |
| nucleotide binding | |
| ATP binding | |
| structural constituent of cytoskeleton | |
| costamere | |
| filamentous actin | |
| cytoplasm | |
| cytosol | |
| myofibril | |
| cytoskeleton | |
| actin cytoskeleton | |
| axon |
| MedScan ID | 71 |
|---|---|
| 295810 | |
| 650751 |
| Hugo ID | 144 |
|---|
| Human chromosome position | 17q25 |
|---|
| LocusLink ID | 71 |
|---|---|
| 11465 | |
| 287876 | |
| 100361457 | |
| 295810 |
| Alias | ACT |
|---|---|
| ACTG | |
| BRWS2 | |
| DFNA20 | |
| DFNA26 | |
| actin, cytoplasmic 2 | |
| cytoskeletal gamma-actin | |
| E51 | |
| Actl | |
| AL023024 | |
| RP23-82I5.1 | |
| gamma-actin | |
| beta-actin FE-3 | |
| actin, gamma, cytoplasmic 1 | |
| actin, gamma 1 propeptide-like | |
| OTTMUSP00000004544 | |
| cytoskeletal actin gamma | |
| deafness, autosomal dominant 20 | |
| deafness, autosomal dominant 20; deafness, autosomal dominant 26 | |
| deafness, autosomal dominant 26 | |
| cytoplasmic gamma actin | |
| Gamma-actin 1 | |
| cytoplasmic actin, gamma | |
| MGC28612 | |
| ACTIN, CYTOPLASMIC TYPE 8 | |
| OTTMUSP00000004545 | |
| OTTMUSP00000004546 | |
| RE12057p | |
| MGC117491 | |
| actin isoform A | |
| actin, gamma I | |
| ACTG I | |
| Actg protein | |
| ACTG1 | |
| actin, gamma 1 propeptide | |
| actin 12 | |
| cytoplasmic actin 2 | |
| actin XII | |
| actin, cytoplasmic II | |
| ACTIN, CYTOPLASMIC TYPE VIII | |
| actin - California sea hare | |
| actin, gamma 1 | |
| LOC295810 | |
| LOC100361457 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 102560 |
|---|---|
| 614583 | |
| 604717 |
| Unigene ID | Hs.514581 |
|---|---|
| Hs.731391 | |
| Mm.196173 | |
| Mm.426706 | |
| Rn.101464 | |
| Rn.106826 |
| KEGG ID | hsa:71 |
|---|---|
| mmu:11465 | |
| rno:287876 | |
| rno:100361457 |
| Swiss-Prot Accession | P63261 |
|---|---|
| P63260 | |
| Q4KL81 | |
| P63259 | |
| A8K7C2 | |
| P02571 | |
| P14104 | |
| P99022 | |
| Q5U032 | |
| Q96E67 |
| GO ID | 0005524 |
|---|---|
| 0019901 | |
| 0005200 | |
| 0034332 | |
| 0007411 | |
| 0007596 | |
| 0034329 | |
| 0045216 | |
| 0006928 | |
| 0051592 | |
| 0045214 | |
| 0030424 | |
| 0005856 | |
| 0005829 | |
| 0031941 | |
| 0030016 | |
| 0000166 | |
| 0015629 | |
| 0043034 | |
| 0005737 | |
| 0007409 |
| PIR ID | A28098 |
|---|---|
| JC5818 | |
| A38571 | |
| S11222 | |
| A30243 |
| Swiss-Prot ID | ACTG_HUMAN |
|---|---|
| ACTG_RAT | |
| ACTG_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| cytoskeleton |
| IPI ID | IPI00021440 |
|---|---|
| IPI00896224 | |
| IPI00874482 |
| Mouse chromosome position | 11 |
|---|
| Rat chromosome position | 10q32.3 |
|---|---|
| 3 |
| MGI ID | 87906 |
|---|
| RGD ID | 1304556 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|