| URN | urn:agi-llid:4641 |
|---|---|
| Total Entities | 0 |
| Connectivity | 97 |
| Name | Myo1c |
| Description | myosin IC |
| Notes | This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Actomyosin based movement |
|---|
| GO Molecular Function | calmodulin binding |
|---|---|
| calcium-dependent protein binding | |
| protein C-terminus binding | |
| actin binding | |
| nucleotide binding | |
| ATP binding | |
| phospholipid binding | |
| motor activity | |
| microfilament motor activity | |
| actin-dependent ATPase activity |
| GO Cellular Component | membrane |
|---|---|
| stereocilium | |
| stereocilium membrane | |
| nuclear pore | |
| nucleoplasm | |
| nucleolus | |
| myosin complex | |
| filamentous actin | |
| stress fiber | |
| unconventional myosin complex | |
| myosin I complex | |
| lateral plasma membrane | |
| basal plasma membrane | |
| axolemma | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| smooth endoplasmic reticulum | |
| nucleus | |
| microvillus | |
| brush border |
| GO Biological Process | transport |
|---|---|
| protein transport | |
| mRNA transport |
| Pathway | auditory mechanotransduction pathway |
|---|
| Group | Actomyosin based movement |
|---|---|
| transport | |
| protein transport | |
| mRNA transport | |
| calmodulin binding | |
| calcium-dependent protein binding | |
| protein C-terminus binding | |
| actin binding | |
| nucleotide binding | |
| ATP binding | |
| phospholipid binding | |
| motor activity | |
| microfilament motor activity | |
| actin-dependent ATPase activity | |
| membrane | |
| stereocilium | |
| stereocilium membrane | |
| nuclear pore | |
| nucleoplasm | |
| nucleolus | |
| myosin complex | |
| filamentous actin | |
| stress fiber | |
| unconventional myosin complex | |
| myosin I complex | |
| lateral plasma membrane | |
| basal plasma membrane | |
| axolemma | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| smooth endoplasmic reticulum | |
| nucleus | |
| microvillus | |
| brush border |
| MedScan ID | 4641 |
|---|---|
| 615364 | |
| 654930 |
| Hugo ID | 7597 |
|---|
| Human chromosome position | 17p13.3 |
|---|
| LocusLink ID | 4641 |
|---|---|
| 17913 | |
| 65261 | |
| 686250 | |
| 100365624 |
| Alias | NMI |
|---|---|
| MMIb | |
| myr2 | |
| MMI-beta | |
| unconventional myosin-Ic | |
| myosin-Ic | |
| myosin I beta | |
| myosin-I beta | |
| nuclear myosin I | |
| MYO1E | |
| C80397 | |
| mm1beta | |
| RP23-136K12.2 | |
| myosin-Ibeta | |
| nuclear myosin I beta | |
| myosin heavy chain myr 2 | |
| unconventional myosin Myr2 I heavy chain | |
| Unconventional myosin from rat 4 for myosin I heavy chain | |
| OTTMUSP00000006511 | |
| OTTMUSP00000006510 | |
| OTTMUSP00000006508 | |
| FLJ23903 | |
| myosin 1C | |
| MYO1C | |
| myosin IC | |
| MGC93573 | |
| LOC686250 | |
| LOC100365624 | |
| myosin IC-like |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606538 |
|---|
| Unigene ID | Hs.286226 |
|---|---|
| Mm.234502 | |
| Rn.55135 |
| KEGG ID | hsa:4641 |
|---|---|
| mmu:17913 | |
| rno:65261 |
| Swiss-Prot Accession | O00159 |
|---|---|
| Q9WTI7 | |
| Q63355 | |
| O08571 | |
| O08834 | |
| Q3TBQ4 | |
| Q3U231 | |
| Q5ND46 | |
| Q5ND48 | |
| Q5ND49 | |
| Q9ERB6 | |
| Q9QW54 | |
| Q4LE56 | |
| Q6NVJ7 | |
| Q86Y95 |
| GO ID | 0005524 |
|---|---|
| 0003779 | |
| 0005516 | |
| 0003774 | |
| 0008022 | |
| 0051028 | |
| 0015031 | |
| 0009925 | |
| 0005903 | |
| 0005737 | |
| 0031941 | |
| 0016328 | |
| 0005902 | |
| 0045160 | |
| 0005643 | |
| 0005730 | |
| 0005654 | |
| 0060171 | |
| 0001725 | |
| 0016461 | |
| 0030898 | |
| 0048306 | |
| 0000146 | |
| 0000166 | |
| 0005543 | |
| 0006810 | |
| 0030673 | |
| 0042995 | |
| 0016020 | |
| 0016459 | |
| 0005634 | |
| 0005886 | |
| 0005790 | |
| 0032420 |
| PIR ID | B45438 |
|---|---|
| H75634 | |
| A59253 | |
| S37146 |
| Swiss-Prot ID | MYO1C_MOUSE |
|---|---|
| MYO1C_HUMAN | |
| MYO1C_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Cell membrane | |
| Cell projection | |
| stereocilium membrane | |
| Nucleus | |
| nucleolus | |
| nucleoplasm | |
| nuclear pore complex |
| IPI ID | IPI00467172 |
|---|---|
| IPI00620222 | |
| IPI00754649 | |
| IPI00928288 | |
| IPI00010418 | |
| IPI00743335 | |
| IPI00829992 | |
| IPI00393867 |
| Mouse chromosome position | 11 44.13 cM |
|---|
| Rat chromosome position | 10q24 |
|---|
| Homologene ID | 32046 |
|---|
| MGI ID | 106612 |
|---|
| RGD ID | 620443 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|