Protein Rbp3

URN	urn:agi-llid:5949
Total Entities	0
Connectivity	117
Name	Rbp3
Description	retinol binding protein 3, interstitial
Notes	Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq]

Ariadne Ontology	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	retinol binding
	retinal binding
	retinoid binding
	serine-type peptidase activity

GO Cellular Component	extracellular region
	proteinaceous extracellular matrix
	interphotoreceptor matrix

GO Biological Process	eye photoreceptor cell development
	retinoid metabolic process
	visual perception
	transport
	lipid metabolic process
	proteolysis

Pathway	retinoid cycle metabolic pathway
	retinitis pigmentosa pathway
	altered retinoid cycle metabolic pathway

Group	eye photoreceptor cell development
	retinoid metabolic process
	visual perception
	transport
	lipid metabolic process
	proteolysis
	retinol binding
	retinal binding
	retinoid binding
	serine-type peptidase activity
	extracellular region
	proteinaceous extracellular matrix
	interphotoreceptor matrix
	Secreted proteins
	Biofluids assayable substances

MedScan ID	5949

Hugo ID	9921

Human chromosome position	10q11.2

Alias	IRBP
	RBPI
	D10S64
	D10S65
	D10S66
	retinol-binding protein 3
	interphotoreceptor retinoid-binding protein
	Rbp-3
	interstitial retinol-binding protein
	interphotoreceptor retinoid binding protein
	interphotoreceptor retinol- binding protein
	MGC102323
	OTTHUMP00000019536
	Rbp3
	retinol binding protein 3, interstitial
	retinol-binding protein-3
	LOC218905
	interphotoreceptor retinol binding protein
	interphotoreceptor retinol-binding protein
	interstitial retinoid binding protein
	interstitial retinoid-binding protein
	Interstitial retinol binding protein
	retinol-binding protein 3, interstitial

OMIM ID	180290
	268000

PIR ID	A33812

Mouse chromosome position	14 13.0 cM

Rat chromosome position	16p16

Homologene ID	9261

MGI ID	97878

RGD ID	3545