| URN | urn:agi-llid:9227 |
|---|---|
| Total Entities | 0 |
| Connectivity | 94 |
| Name | Lrat |
| Description | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) |
| Notes | The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq] |
| Ariadne Ontology | Biofluids assayable substances |
|---|
| GO Molecular Function | retinol binding |
|---|---|
| retinoic acid binding | |
| transferase activity | |
| transferase activity, transferring acyl groups | |
| O-acyltransferase activity | |
| phosphatidylcholine-retinol O-acyltransferase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| integral to membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endosome | |
| endoplasmic reticulum | |
| multivesicular body | |
| rough endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | response to stimulus |
|---|---|
| retinoic acid metabolic process | |
| 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process | |
| retinoid metabolic process | |
| vitamin A metabolic process | |
| retinol metabolic process | |
| embryo development | |
| visual perception | |
| steroid metabolic process | |
| small molecule metabolic process |
| Pathway | retinoic acid metabolic pathway |
|---|---|
| retinoid cycle metabolic pathway | |
| retinol metabolic pathway | |
| retinitis pigmentosa pathway | |
| altered retinoid cycle metabolic pathway |
| Group | response to stimulus |
|---|---|
| retinoic acid metabolic process | |
| 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process | |
| retinoid metabolic process | |
| vitamin A metabolic process | |
| retinol metabolic process | |
| embryo development | |
| visual perception | |
| steroid metabolic process | |
| small molecule metabolic process | |
| retinol binding | |
| retinoic acid binding | |
| transferase activity | |
| transferase activity, transferring acyl groups | |
| O-acyltransferase activity | |
| phosphatidylcholine-retinol O-acyltransferase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| integral to membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endosome | |
| endoplasmic reticulum | |
| multivesicular body | |
| rough endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Biofluids assayable substances |
| MedScan ID | 9227 |
|---|
| Hugo ID | 6685 |
|---|
| Human chromosome position | 4q32.1 |
|---|
| LocusLink ID | 9227 |
|---|---|
| 79235 | |
| 64047 |
| Alias | LCA14 |
|---|---|
| lecithin retinol acyltransferase | |
| AI449251 | |
| 1300010A18Rik | |
| phosphatidylcholine-retinol-O-acyltransferase | |
| phosphatidylcholine--retinol O-acyltransferase | |
| lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | |
| LOC299882 | |
| phosphatidylcholine-retinol O-acyltransferase | |
| MGC33103 | |
| Lrat | |
| LOC497758 | |
| 1300010A18 | |
| lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604863 |
|---|---|
| 613341 | |
| 268000 |
| Unigene ID | Hs.658427 |
|---|---|
| Mm.33921 | |
| Rn.137431 |
| KEGG ID | hsa:9227 |
|---|---|
| mmu:79235 | |
| rno:64047 |
| Swiss-Prot Accession | O95237 |
|---|---|
| B2RUR5 | |
| Q9JI60 | |
| Q9JI61 | |
| A8K983 | |
| Q8N716 |
| EC Number | 2.3.1.135 |
|---|
| GO ID | 0047173 |
|---|---|
| 0001972 | |
| 0019841 | |
| 0016746 | |
| 0009790 | |
| 0050896 | |
| 0001523 | |
| 0042572 | |
| 0044281 | |
| 0008202 | |
| 0007601 | |
| 0005789 | |
| 0016021 | |
| 0005771 | |
| 0048471 | |
| 0005791 | |
| 0008374 | |
| 0016740 | |
| 0006653 | |
| 0006776 | |
| 0005737 | |
| 0005783 | |
| 0005768 | |
| 0043231 | |
| 0016020 | |
| 0042573 | |
| 0008415 | |
| 0005792 |
| Swiss-Prot ID | LRAT_HUMAN |
|---|---|
| LRAT_MOUSE | |
| LRAT_RAT | |
| B2RUR5_MOUSE | |
| A8K983_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Rough endoplasmic reticulum | |
| Endosome | |
| multivesicular body | |
| Cytoplasm | |
| perinuclear region |
| IPI ID | IPI00006231 |
|---|---|
| IPI00119943 | |
| IPI00199982 | |
| IPI00735216 |
| Mouse chromosome position | 3 |
|---|
| Rat chromosome position | 2q34 |
|---|
| Homologene ID | 3483 |
|---|
| MGI ID | 1891259 |
|---|
| RGD ID | 68362 |
|---|