| URN | urn:agi-llid:6011 |
|---|---|
| Total Entities | 0 |
| Connectivity | 141 |
| Name | Grk1 |
| Description | G protein-coupled receptor kinase 1 |
| Notes | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq] |
| Ariadne Ontology | GRK |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| rhodopsin kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity |
| GO Cellular Component | membrane |
|---|
| GO Biological Process | regulation of G-protein coupled receptor protein signaling pathway |
|---|---|
| termination of G-protein coupled receptor signaling pathway | |
| regulation of rhodopsin mediated signaling pathway | |
| signal transduction | |
| rhodopsin mediated signaling pathway | |
| positive regulation of phosphorylation | |
| photoreceptor cell morphogenesis | |
| protein phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| apoptotic process | |
| response to drug | |
| response to light stimulus | |
| post-embryonic retina morphogenesis in camera-type eye | |
| visual perception |
| Pathway | visual phototransduction pathway |
|---|---|
| altered visual phototransduction pathway |
| Group | GRK |
|---|---|
| regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| regulation of rhodopsin mediated signaling pathway | |
| signal transduction | |
| rhodopsin mediated signaling pathway | |
| positive regulation of phosphorylation | |
| photoreceptor cell morphogenesis | |
| protein phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| apoptotic process | |
| response to drug | |
| response to light stimulus | |
| post-embryonic retina morphogenesis in camera-type eye | |
| visual perception | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| rhodopsin kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity | |
| membrane |
| MedScan ID | 6011 |
|---|
| Hugo ID | 10013 |
|---|
| Human chromosome position | 13q34 |
|---|
| LocusLink ID | 6011 |
|---|---|
| 24013 | |
| 81760 |
| Alias | RK |
|---|---|
| RHOK | |
| GPRK1 | |
| rhodopsin kinase | |
| G-protein receptor kinase 1 | |
| G protein-coupled receptpr kinase 1 | |
| G protein-coupled receptor kinase I | |
| GRK1 | |
| GPCR kinase 1 | |
| opsin kinase | |
| LOC360287 | |
| G protein-coupled receptor kinase 1b | |
| G protein-coupled receptor kinase 1 | |
| G protein receptor kinase I | |
| G protein receptor kinase 1 | |
| GRK I | |
| opsin kinases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 180381 |
|---|---|
| 613411 | |
| 258100 |
| Unigene ID | Hs.103501 |
|---|---|
| Hs.721727 | |
| Mm.257501 | |
| Rn.10548 |
| KEGG ID | hsa:6011 |
|---|---|
| mmu:24013 | |
| rno:81760 |
| Swiss-Prot Accession | Q15835 |
|---|---|
| G3X905 | |
| Q4V9Z9 | |
| Q9WVL4 | |
| Q63651 | |
| Q53X14 | |
| O95098 | |
| Q6VTF2 | |
| Q71VB6 |
| EC Number | 2.7.11.14 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004703 | |
| 0004672 | |
| 0050254 | |
| 0006915 | |
| 0008594 | |
| 0042327 | |
| 0060060 | |
| 0046777 | |
| 0008277 | |
| 0022400 | |
| 0042493 | |
| 0016056 | |
| 0038032 | |
| 0007601 | |
| 0016020 | |
| 0016301 | |
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0016310 | |
| 0006468 | |
| 0009416 | |
| 0007165 | |
| 0004871 | |
| 0050896 | |
| 0009586 | |
| 0004872 |
| Swiss-Prot ID | RK_HUMAN |
|---|---|
| RK_RAT | |
| Q4V9Z9_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00019980 |
|---|---|
| IPI00211058 | |
| IPI00126128 | |
| IPI00383569 |
| Mouse chromosome position | 8 |
|---|
| Rat chromosome position | 16q12.5 |
|---|
| Homologene ID | 2197 |
|---|
| MGI ID | 1345146 |
|---|
| RGD ID | 619712 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|