| URN | urn:agi-llid:2986 |
|---|---|
| Total Entities | 0 |
| Connectivity | 16 |
| Name | Gucy2f |
| Description | guanylate cyclase 2F, retinal |
| Notes | The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq] |
| Ariadne Ontology | GCR |
|---|
| GO Molecular Function | receptor activity |
|---|---|
| protein homodimerization activity | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| GTP binding | |
| lyase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| protein kinase activity | |
| guanylate cyclase activity | |
| phosphorus-oxygen lyase activity |
| GO Cellular Component | membrane |
|---|---|
| nuclear outer membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| intracellular |
| GO Biological Process | response to stimulus |
|---|---|
| intracellular signal transduction | |
| receptor guanylyl cyclase signaling pathway | |
| cGMP biosynthetic process | |
| cyclic nucleotide biosynthetic process | |
| protein phosphorylation | |
| visual perception |
| Pathway | visual phototransduction pathway |
|---|---|
| altered visual phototransduction pathway |
| Group | GCR |
|---|---|
| response to stimulus | |
| intracellular signal transduction | |
| receptor guanylyl cyclase signaling pathway | |
| cGMP biosynthetic process | |
| cyclic nucleotide biosynthetic process | |
| protein phosphorylation | |
| visual perception | |
| receptor activity | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| GTP binding | |
| lyase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| protein kinase activity | |
| guanylate cyclase activity | |
| phosphorus-oxygen lyase activity | |
| membrane | |
| nuclear outer membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| intracellular |
| MedScan ID | 2986 |
|---|
| Hugo ID | 4691 |
|---|
| Human chromosome position | Xq22 |
|---|
| LocusLink ID | 2986 |
|---|---|
| 245650 | |
| 116556 |
| Alias | CYGF |
|---|---|
| GC-F | |
| GUC2F | |
| GUC2DL | |
| RETGC-2 | |
| ROS-GC2 | |
| retinal guanylyl cyclase 2 | |
| guanylate cyclase F | |
| rod outer segment membrane guanylate cyclase 2 | |
| guanylate cyclase 2D-like, membrane (retina-specific) | |
| GC2 | |
| A930002I06 | |
| RP23-294O1.4 | |
| guanylate cyclase 2F, retinal | |
| RETGC2 | |
| GUCY2F | |
| OTTHUMP00000023839 | |
| Rod outer segment membrane guanylate cyclase II | |
| OTTMUSP00000020265 | |
| guanylyl cyclase 2f | |
| guanylate cyclase 2F | |
| RetGC II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300041 |
|---|
| Unigene ID | Hs.123074 |
|---|---|
| Mm.208511 | |
| Rn.10061 |
| KEGG ID | hsa:2986 |
|---|---|
| mmu:245650 | |
| rno:116556 |
| Swiss-Prot Accession | P51841 |
|---|---|
| Q5SDA5 | |
| P51842 | |
| Q9UJF1 | |
| Q8BLL8 |
| EC Number | 4.6.1.2 |
|---|
| GO ID | 0005524 |
|---|---|
| 0005525 | |
| 0004383 | |
| 0046982 | |
| 0042803 | |
| 0004672 | |
| 0004872 | |
| 0035556 | |
| 0007168 | |
| 0007601 | |
| 0005887 | |
| 0005640 | |
| 0016829 | |
| 0000166 | |
| 0016849 | |
| 0016772 | |
| 0006182 | |
| 0009190 | |
| 0006468 | |
| 0050896 | |
| 0016021 | |
| 0016020 | |
| 0005622 | |
| 0023034 | |
| 0005624 | |
| 0007242 |
| PIR ID | I59385 |
|---|---|
| B55915 |
| Swiss-Prot ID | GUC2F_HUMAN |
|---|---|
| GUC2F_RAT | |
| GUC2F_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00020942 |
|---|---|
| IPI00206274 | |
| IPI00345822 |
| Mouse chromosome position | X 61.0 cM |
|---|
| Rat chromosome position | Xq14 |
|---|
| Homologene ID | 37491 |
|---|
| MGI ID | 105119 |
|---|
| RGD ID | 620439 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|