Protein Gnat1

URN	urn:agi-llid:2779
Total Entities	0
Connectivity	213
Name	Gnat1
Description	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
Notes	Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

Ariadne Ontology	Gt

GO Molecular Function	acyl binding
	G-protein beta-gamma-subunit complex binding
	G-protein coupled receptor binding
	protein kinase binding
	nucleotide binding
	GTP binding
	GDP binding
	guanyl nucleotide binding
	metal ion binding
	GTPase activity
	signal transducer activity

GO Cellular Component	membrane
	photoreceptor outer segment membrane
	apical plasma membrane
	extrinsic to internal side of plasma membrane
	heterotrimeric G-protein complex
	plasma membrane
	photoreceptor inner segment
	cytoplasm
	photoreceptor outer segment
	photoreceptor connecting cilium
	neuronal cell body

GO Biological Process	response to stimulus
	cell proliferation
	signal transduction
	phototransduction
	G-protein coupled receptor signaling pathway
	rhodopsin mediated signaling pathway
	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
	phototransduction, visible light
	eye photoreceptor cell development
	GTP catabolic process
	cellular response to electrical stimulus
	detection of chemical stimulus involved in sensory perception of bitter taste
	detection of light stimulus involved in visual perception
	response to light stimulus
	response to light intensity
	negative regulation of cyclic-nucleotide phosphodiesterase activity
	positive regulation of cyclic-nucleotide phosphodiesterase activity
	retina development in camera-type eye
	sensory perception of umami taste
	visual perception

Pathway	visual phototransduction pathway
	altered visual phototransduction pathway

Group	Gt
	response to stimulus
	cell proliferation
	signal transduction
	phototransduction
	G-protein coupled receptor signaling pathway
	rhodopsin mediated signaling pathway
	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
	phototransduction, visible light
	eye photoreceptor cell development
	GTP catabolic process
	cellular response to electrical stimulus
	detection of chemical stimulus involved in sensory perception of bitter taste
	detection of light stimulus involved in visual perception
	response to light stimulus
	response to light intensity
	negative regulation of cyclic-nucleotide phosphodiesterase activity
	positive regulation of cyclic-nucleotide phosphodiesterase activity
	retina development in camera-type eye
	sensory perception of umami taste
	visual perception
	acyl binding
	G-protein beta-gamma-subunit complex binding
	G-protein coupled receptor binding
	protein kinase binding
	nucleotide binding
	GTP binding
	GDP binding
	guanyl nucleotide binding
	metal ion binding
	GTPase activity
	signal transducer activity
	membrane
	photoreceptor outer segment membrane
	apical plasma membrane
	extrinsic to internal side of plasma membrane
	heterotrimeric G-protein complex
	plasma membrane
	photoreceptor inner segment
	cytoplasm
	photoreceptor outer segment
	photoreceptor connecting cilium
	neuronal cell body

MedScan ID	2779

Hugo ID	4393

Human chromosome position	3p21

Alias	GBT1
	GNATR
	CSNBAD3
	guanine nucleotide-binding protein G(t) subunit alpha-1
	transducin alpha-1 chain
	transducin, rod-specific
	rod-type transducin alpha subunit
	guanine nucleotide-binding protein G(T), alpha-1 subunit
	Ird1
	Ird2
	irdc
	irdr
	Gnat-1
	Tralpha
	transducin
	rCG_26094
	guanine nucleotide binding protein, alpha transducing 1
	guanine nucleotide binding protein (G protein), alpha transducing 1
	guanine nucleotide binding protein, alpha transducing I
	guanine nucleotide binding, alpha transducing
	guanine nucleotide binding, alpha transducing activity polypeptide
	GBT I
	guanine nucleotide binding protein, alpha transducing activity polypeptide 1
	G(T), alpha-1 subunit
	G(T), alpha-1
	(G protein), alpha transducing activity polypeptide I
	Gnat I
	(G protein), alpha transducing activity polypeptide 1
	Gnat1
	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
	G(T), alpha I

OMIM ID	139330
	610444

PIR ID	A33352
	S22953

Swiss-Prot ID	GNAT1_MOUSE
	GNAT1_HUMAN

Cell Localization	Cytoplasm

Mouse chromosome position	9 59.0 cM

Rat chromosome position	8q32

Homologene ID	20084

MGI ID	95778

RGD ID	1304683

Primary Cell Localization	Cytoplasm