| URN | urn:agi-llid:6295 |
|---|---|
| Total Entities | 0 |
| Connectivity | 168 |
| Name | Sag |
| Description | S-antigen; retina and pineal gland (arrestin) |
| Notes | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | opsin binding |
|---|---|
| phosphoprotein binding | |
| protein phosphatase inhibitor activity |
| GO Cellular Component | photoreceptor inner segment |
|---|---|
| photoreceptor outer segment |
| GO Biological Process | response to stimulus |
|---|---|
| signal transduction | |
| cell surface receptor signaling pathway | |
| rhodopsin mediated signaling pathway | |
| visual perception |
| Pathway | visual phototransduction pathway |
|---|---|
| retinitis pigmentosa pathway | |
| altered visual phototransduction pathway |
| Group | response to stimulus |
|---|---|
| signal transduction | |
| cell surface receptor signaling pathway | |
| rhodopsin mediated signaling pathway | |
| visual perception | |
| opsin binding | |
| phosphoprotein binding | |
| protein phosphatase inhibitor activity | |
| photoreceptor inner segment | |
| photoreceptor outer segment | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 6295 |
|---|---|
| 613548 |
| Hugo ID | 10521 |
|---|
| Human chromosome position | 2q37.1 |
|---|
| LocusLink ID | 6295 |
|---|---|
| 20215 | |
| 25539 | |
| 683311 |
| Alias | RP47 |
|---|---|
| S-AG | |
| S-arrestin | |
| arrestin 1 | |
| 48 kDa protein | |
| rod photoreceptor arrestin | |
| retinal S-antigen (48 KDa protein) | |
| Arr1 | |
| Irbp | |
| arrestin | |
| A930001K18Rik | |
| rod arrestin | |
| visual arrestin 1 | |
| SAGMR | |
| SANTI | |
| S-antigen | |
| retinal S-antigen | |
| visual arrestin | |
| SAG antigen | |
| SAG gene | |
| SAG protein | |
| S-antigen, retina and pineal gland (arrestin) | |
| S-antigen; retina and pineal gland (arrestin) | |
| synArfGEF | |
| 48 kDa arrestin | |
| arrestin-S | |
| DKFZp686D1084 | |
| DKFZp686I1383 | |
| OTTHUMP00000203381 | |
| OTTMUSP00000024441 | |
| retina and pineal gland S-antigen | |
| retinal S-antigen (48 KDa) | |
| A930001K18 | |
| LOC683311 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 181031 |
|---|---|
| 258100 | |
| 613758 |
| Unigene ID | Hs.32721 |
|---|---|
| Mm.1276 | |
| Rn.9856 |
| KEGG ID | hsa:6295 |
|---|---|
| mmu:20215 | |
| rno:25539 |
| Swiss-Prot Accession | A0FDN6 |
|---|---|
| P10523 | |
| P20443 | |
| Q3UPX6 | |
| P15887 | |
| Q53SV3 | |
| Q99858 | |
| Q91W62 | |
| Q6MZK5 | |
| Q7Z3R3 | |
| Q3UEW3 | |
| Q8BPV0 | |
| Q8C8Y8 |
| GO ID | 0002046 |
|---|---|
| 0051219 | |
| 0004864 | |
| 0007166 | |
| 0016056 | |
| 0007601 | |
| 0050896 | |
| 0007165 | |
| 0001917 | |
| 0001750 | |
| 0009586 | |
| 0007600 | |
| 0005509 |
| PIR ID | A30357 |
|---|---|
| JS0066 | |
| S03960 |
| Swiss-Prot ID | ARRS_HUMAN |
|---|---|
| ARRS_MOUSE | |
| ARRS_RAT | |
| A0FDN6_HUMAN | |
| Q3UPX6_MOUSE |
| IPI ID | IPI00021353 |
|---|---|
| IPI00229940 | |
| IPI00327771 | |
| IPI00917616 | |
| IPI00385695 | |
| IPI00425942 | |
| IPI00385032 |
| Mouse chromosome position | 1 53.6 cM |
|---|
| Rat chromosome position | 9q35 |
|---|
| Homologene ID | 455 |
|---|
| MGI ID | 98227 |
|---|
| RGD ID | 3619 |
|---|