Elsevier Inc. Metformin ---| Diabetes Mellitus, Type 2 Metformin ---| type 2 diabetes mellitus pathway type 2 diabetes mellitus pathway Metformin metformin pharmacokinetics pathway ROS respiratory complex I adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Metformin ---| respiratory complex I oxidative phosphorylation pathway Metformin --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Diabetes Mellitus, Type 2