| URN | urn:agi-llid:6581 |
|---|---|
| Total Entities | 0 |
| Connectivity | 110 |
| Name | Slc22a3 |
| Description | solute carrier family 22 (extraneuronal monoamine transporter), member 3 |
| Notes | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Organic anions transport |
|---|---|
| Other transport proteins | |
| Secreted proteins |
| GO Molecular Function | transporter activity |
|---|---|
| transmembrane transporter activity | |
| toxin transporter activity | |
| ion transmembrane transporter activity | |
| dopamine transmembrane transporter activity | |
| organic cation transmembrane transporter activity | |
| quaternary ammonium group transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane |
| GO Biological Process | transmembrane transport |
|---|---|
| ion transmembrane transport | |
| drug transmembrane transport | |
| transport | |
| ion transport | |
| histamine uptake | |
| dopamine transport | |
| histamine transport | |
| organic cation transport | |
| quaternary ammonium group transport | |
| monoamine transport | |
| small molecule metabolic process | |
| regulation of appetite |
| Pathway | metformin pharmacokinetics pathway |
|---|---|
| metformin-gene, gene-chemical, gene-gene interaction pathway |
| Group | Organic anions transport |
|---|---|
| Other transport proteins | |
| transmembrane transport | |
| ion transmembrane transport | |
| drug transmembrane transport | |
| transport | |
| ion transport | |
| histamine uptake | |
| dopamine transport | |
| histamine transport | |
| organic cation transport | |
| quaternary ammonium group transport | |
| monoamine transport | |
| small molecule metabolic process | |
| regulation of appetite | |
| transporter activity | |
| transmembrane transporter activity | |
| toxin transporter activity | |
| ion transmembrane transporter activity | |
| dopamine transmembrane transporter activity | |
| organic cation transmembrane transporter activity | |
| quaternary ammonium group transmembrane transporter activity | |
| membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| Secreted proteins |
| MedScan ID | 6581 |
|---|
| Hugo ID | 10967 |
|---|
| Human chromosome position | 6q25.3 |
|---|
| LocusLink ID | 6581 |
|---|---|
| 20519 | |
| 29504 |
| Alias | EMT |
|---|---|
| EMTH | |
| OCT3 | |
| RP11-72O9.3 | |
| solute carrier family 22 member 3 | |
| organic cation transporter 3 | |
| EMT organic cation transporter 3 | |
| extraneuronal monoamine transporter | |
| Orct3 | |
| Slca22a3 | |
| solute carrier family 22, member 3 | |
| solute carrier family 22 (organic cation transporter), member 3 | |
| LOC253271 | |
| solute carrier family 22 (organic cation transporter), member III | |
| solute carrier family 22 (extraneuronal monoamine transporter), member III | |
| Slc22a3 | |
| solute carrier family 22 (extraneuronal monoamine transporter), member 3 | |
| solute carrier family 22 member III | |
| OTTHUMP00000017542 | |
| Organic cation transporter III | |
| EMT organic cation transporter III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604842 |
|---|
| Unigene ID | Hs.567337 |
|---|---|
| Mm.99252 | |
| Rn.24231 |
| KEGG ID | hsa:6581 |
|---|---|
| mmu:20519 | |
| rno:29504 |
| Swiss-Prot Accession | O75751 |
|---|---|
| Q547K2 | |
| Q9WTW5 | |
| O88446 | |
| Q9R209 | |
| Q5SYN6 | |
| Q9UP02 |
| GO ID | 0005329 |
|---|---|
| 0015101 | |
| 0015651 | |
| 0019534 | |
| 0006855 | |
| 0051615 | |
| 0015695 | |
| 0015697 | |
| 0032098 | |
| 0044281 | |
| 0055085 | |
| 0005887 | |
| 0016020 | |
| 0005886 | |
| 0015075 | |
| 0022857 | |
| 0005215 | |
| 0015872 | |
| 0051608 | |
| 0034220 | |
| 0006811 | |
| 0015844 | |
| 0006810 | |
| 0016021 |
| Swiss-Prot ID | S22A3_MOUSE |
|---|---|
| S22A3_HUMAN | |
| S22A3_RAT |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00123976 |
|---|---|
| IPI00872448 | |
| IPI00209578 |
| Mouse chromosome position | 17 7.31 cM |
|---|
| Rat chromosome position | 1q11 |
|---|
| Homologene ID | 22630 |
|---|
| MGI ID | 1333817 |
|---|
| RGD ID | 3701 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|