| URN | urn:agi-llid:7412 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1955 |
| Name | Vcam1 |
| Description | vascular cell adhesion molecule 1 |
| Notes | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq] |
| Ariadne Ontology | ECM-Cell adhesion proteins |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | cell adhesion molecule binding |
|---|---|
| integrin binding |
| GO Cellular Component | membrane |
|---|---|
| podosome | |
| alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex | |
| external side of plasma membrane | |
| integral to membrane | |
| anchored to membrane | |
| apical part of cell | |
| plasma membrane | |
| cell surface | |
| cell periphery | |
| filopodium | |
| microvillus | |
| sarcolemma | |
| extracellular space |
| GO Biological Process | virus-host interaction |
|---|---|
| cell adhesion | |
| cytokine-mediated signaling pathway | |
| interferon-gamma-mediated signaling pathway | |
| positive regulation of T cell proliferation | |
| B cell differentiation | |
| cell-cell adhesion | |
| leukocyte cell-cell adhesion | |
| heterophilic cell-cell adhesion | |
| chorio-allantoic fusion | |
| leukocyte tethering or rolling | |
| cellular response to glucose stimulus | |
| membrane to membrane docking | |
| regulation of immune response | |
| response to nutrient | |
| response to hypoxia | |
| acute inflammatory response | |
| chronic inflammatory response | |
| response to ionizing radiation | |
| aging | |
| visceral serous pericardium development | |
| heart development | |
| embryonic placenta morphogenesis |
| Pathway | ROS in Triggering Vascular Inflammation |
|---|---|
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| LTA Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| CD40LG/STAT Expression Targets | |
| ICAM1 Expression Targets | |
| PECAM1 Expression Targets | |
| IL13 Expression Targets | |
| IL7 Expression Targets | |
| IL2 Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| IFNG-IFNR Expression Targets | |
| IFNA1-IFNR Expression Targets | |
| OSM-OSMR Expression Targets | |
| S100B Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| Thromboxane A2 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| GAST Expression Targets | |
| S1P Expression Targets | |
| TAC1 Expression Targets | |
| EDN1 Expression Targets | |
| IGF1/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| VEGFA/STAT Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| drug-gene, gene-chemical, gene-gene interaction pathway | |
| losartan_expanded2 | |
| losartan_expanded3 | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway |
| Group | ECM-Cell adhesion proteins |
|---|---|
| virus-host interaction | |
| cell adhesion | |
| cytokine-mediated signaling pathway | |
| interferon-gamma-mediated signaling pathway | |
| positive regulation of T cell proliferation | |
| B cell differentiation | |
| cell-cell adhesion | |
| leukocyte cell-cell adhesion | |
| heterophilic cell-cell adhesion | |
| chorio-allantoic fusion | |
| leukocyte tethering or rolling | |
| cellular response to glucose stimulus | |
| membrane to membrane docking | |
| regulation of immune response | |
| response to nutrient | |
| response to hypoxia | |
| acute inflammatory response | |
| chronic inflammatory response | |
| response to ionizing radiation | |
| aging | |
| visceral serous pericardium development | |
| heart development | |
| embryonic placenta morphogenesis | |
| cell adhesion molecule binding | |
| integrin binding | |
| membrane | |
| podosome | |
| alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex | |
| external side of plasma membrane | |
| integral to membrane | |
| anchored to membrane | |
| apical part of cell | |
| plasma membrane | |
| cell surface | |
| cell periphery | |
| filopodium | |
| microvillus | |
| sarcolemma | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 7412 |
|---|
| Hugo ID | 12663 |
|---|
| Human chromosome position | 1p32-p31 |
|---|
| LocusLink ID | 7412 |
|---|---|
| 22329 | |
| 25361 |
| Alias | CD106 |
|---|---|
| INCAM-100 | |
| vascular cell adhesion protein 1 | |
| CD106 antigen | |
| Vcam-1 | |
| V-CAM 1 | |
| VCAM1B | |
| L1CAM | |
| OTTHUMP00000012650 | |
| OTTHUMP00000012651 | |
| Vcam1 | |
| V-CAM I | |
| Vcam I | |
| vascular cell adhesion molecule I | |
| vascular cell adhesion molecule 1 | |
| (sVCAM)-1 | |
| MGC99561 | |
| MGC108734 | |
| DKFZp779g2333 | |
| (sVCAM)-I | |
| OTTHUMP00000012652 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 192225 |
|---|
| Unigene ID | Hs.109225 |
|---|---|
| Mm.76649 | |
| Mm.440909 | |
| Rn.11267 |
| KEGG ID | hsa:7412 |
|---|---|
| mmu:22329 | |
| rno:25361 |
| Swiss-Prot Accession | P19320 |
|---|---|
| B4DKS4 | |
| E9PDD1 | |
| P29533 | |
| Q3UPN1 | |
| P29534 | |
| A8K6R7 | |
| Q6NUP8 | |
| Q5FVS3 | |
| Q63669 | |
| Q53FL7 | |
| Q68DC4 | |
| Q3TR98 | |
| Q544V4 | |
| Q8K0X1 | |
| Q91X98 |
| GO ID | 0050839 |
|---|---|
| 0005178 | |
| 0030183 | |
| 0002526 | |
| 0007568 | |
| 0007155 | |
| 0071333 | |
| 0060710 | |
| 0002544 | |
| 0019221 | |
| 0007507 | |
| 0007157 | |
| 0060333 | |
| 0007159 | |
| 0050901 | |
| 0022614 | |
| 0042102 | |
| 0050776 | |
| 0001666 | |
| 0010212 | |
| 0007584 | |
| 0019048 | |
| 0071065 | |
| 0045177 | |
| 0009986 | |
| 0009897 | |
| 0005615 | |
| 0030175 | |
| 0016021 | |
| 0005902 | |
| 0005886 | |
| 0002102 | |
| 0042383 | |
| 0016337 | |
| 0060669 | |
| 0061032 | |
| 0031225 | |
| 0071944 | |
| 0016020 | |
| 0044419 |
| PIR ID | A41288 |
|---|---|
| B41288 | |
| JS0675 | |
| B48919 | |
| JN0581 |
| Swiss-Prot ID | VCAM1_HUMAN |
|---|---|
| VCAM1_RAT | |
| VCAM1_MOUSE | |
| Q3UPN1_MOUSE | |
| A8K6R7_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Extracellular |
| IPI ID | IPI00018136 |
|---|---|
| IPI00082827 | |
| IPI00205631 | |
| IPI00126834 | |
| IPI00264750 | |
| IPI00653571 | |
| IPI00643490 | |
| IPI00643090 | |
| IPI00780065 |
| Mouse chromosome position | 3 50.8 cM |
|---|
| Rat chromosome position | 2q41 |
|---|
| Homologene ID | 838 |
|---|
| MGI ID | 98926 |
|---|
| RGD ID | 3952 |
|---|
| Primary Cell Localization | Extracellular |
|---|