| URN | urn:agi-llid:949 |
|---|---|
| Total Entities | 0 |
| Connectivity | 646 |
| Name | Scarb1 |
| Description | scavenger receptor class B, member 1 |
| Notes | The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| Ariadne Ontology | Scavenger receptor |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | transporter activity |
|---|---|
| apolipoprotein binding | |
| apolipoprotein A-I binding | |
| protein homodimerization activity | |
| lipopolysaccharide binding | |
| phosphatidylserine binding | |
| 1-phosphatidylinositol binding | |
| high-density lipoprotein particle binding | |
| low-density lipoprotein particle binding | |
| lipopolysaccharide receptor activity | |
| high-density lipoprotein particle receptor activity | |
| lipid transporter activity |
| GO Cellular Component | membrane |
|---|---|
| caveola | |
| integral to plasma membrane | |
| microvillus membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| cytoplasm |
| GO Biological Process | virus-host interaction |
|---|---|
| adhesion to symbiont | |
| cell adhesion | |
| lipopolysaccharide-mediated signaling pathway | |
| regulation of phosphatidylcholine catabolic process | |
| positive regulation of triglyceride biosynthetic process | |
| positive regulation of endothelial cell migration | |
| regulation of phagocytosis | |
| lipoprotein metabolic process | |
| androgen biosynthetic process | |
| cholesterol import | |
| phagocytosis, recognition | |
| recognition of apoptotic cell | |
| blood vessel endothelial cell migration | |
| endothelial cell proliferation | |
| detection of lipopolysaccharide | |
| wound healing | |
| positive regulation of cholesterol storage | |
| positive regulation of nitric-oxide synthase activity | |
| high-density lipoprotein particle clearance | |
| low-density lipoprotein particle clearance | |
| high-density lipoprotein particle remodeling | |
| phospholipid transport | |
| lipid transport | |
| lipopolysaccharide transport | |
| cholesterol transport | |
| reverse cholesterol transport | |
| cholesterol efflux | |
| lipid metabolic process | |
| steroid biosynthetic process | |
| cholesterol catabolic process | |
| small molecule metabolic process | |
| cholesterol homeostasis | |
| triglyceride homeostasis |
| Pathway | TNF/STAT Expression Targets |
|---|---|
| Leptin/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| retinol metabolic pathway | |
| drug-gene, gene-chemical, gene-gene interaction pathway | |
| losartan_expanded2 | |
| losartan_expanded3 | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway |
| Group | Scavenger receptor |
|---|---|
| virus-host interaction | |
| adhesion to symbiont | |
| cell adhesion | |
| lipopolysaccharide-mediated signaling pathway | |
| regulation of phosphatidylcholine catabolic process | |
| positive regulation of triglyceride biosynthetic process | |
| positive regulation of endothelial cell migration | |
| regulation of phagocytosis | |
| lipoprotein metabolic process | |
| androgen biosynthetic process | |
| cholesterol import | |
| phagocytosis, recognition | |
| recognition of apoptotic cell | |
| blood vessel endothelial cell migration | |
| endothelial cell proliferation | |
| detection of lipopolysaccharide | |
| wound healing | |
| positive regulation of cholesterol storage | |
| positive regulation of nitric-oxide synthase activity | |
| high-density lipoprotein particle clearance | |
| low-density lipoprotein particle clearance | |
| high-density lipoprotein particle remodeling | |
| phospholipid transport | |
| lipid transport | |
| lipopolysaccharide transport | |
| cholesterol transport | |
| reverse cholesterol transport | |
| cholesterol efflux | |
| lipid metabolic process | |
| steroid biosynthetic process | |
| cholesterol catabolic process | |
| small molecule metabolic process | |
| cholesterol homeostasis | |
| triglyceride homeostasis | |
| transporter activity | |
| apolipoprotein binding | |
| apolipoprotein A-I binding | |
| protein homodimerization activity | |
| lipopolysaccharide binding | |
| phosphatidylserine binding | |
| 1-phosphatidylinositol binding | |
| high-density lipoprotein particle binding | |
| low-density lipoprotein particle binding | |
| lipopolysaccharide receptor activity | |
| high-density lipoprotein particle receptor activity | |
| lipid transporter activity | |
| membrane | |
| caveola | |
| integral to plasma membrane | |
| microvillus membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| cytoplasm | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 949 |
|---|---|
| 621175 |
| Hugo ID | 1664 |
|---|
| Human chromosome position | 12q24.31 |
|---|
| LocusLink ID | 949 |
|---|---|
| 20778 | |
| 25073 | |
| 100034777 |
| Alias | CLA1 |
|---|---|
| SRB1 | |
| CLA-1 | |
| SR-BI | |
| CD36L1 | |
| HDLQTL6 | |
| scavenger receptor class B member 1 | |
| CD36 and LIMPII analogous 1 | |
| scavenger receptor class B type III | |
| CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 | |
| CD36 | |
| SRBI | |
| Hdlq1 | |
| SR-B1 | |
| Hlb398 | |
| mSR-BI | |
| AI120173 | |
| D5Ertd460e | |
| HDL QTL 1 | |
| scavenger receptor class B1 | |
| scavenger receptor class B type I | |
| scavanger receptor class B type 1 | |
| CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1) | |
| scavenger receptor class b | |
| OTTMUSP00000026064 | |
| Scarb I | |
| Scarb1 | |
| Scavanger receptor class B type I | |
| OTTMUSP00000026063 | |
| scavenger receptor class B type 1 | |
| SRB I | |
| MGC6713 | |
| CD36 antigen -like 1 | |
| SR-B I | |
| CD36L I | |
| MGC28623 | |
| CD36 antigen -like I | |
| 4930542G03Rik | |
| CLA I | |
| MGC138242 | |
| DNA segment, Chr 5, ERATO Doi 460, expressed | |
| collagen type I receptor, thrombospondin receptor-like 1 | |
| MGC16435 | |
| HDL quantitative trait locus 1 | |
| CD36 antigen-like 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601040 |
|---|---|
| 610762 |
| Unigene ID | Hs.731377 |
|---|---|
| Mm.282242 | |
| Rn.88169 | |
| Hs.709216 | |
| Mm.474018 |
| KEGG ID | hsa:949 |
|---|---|
| mmu:20778 | |
| rno:25073 |
| Swiss-Prot Accession | F8W8N0 |
|---|---|
| Q8WTV0 | |
| D3Z2V4 | |
| Q61009 | |
| Q4FK30 | |
| P97943 | |
| Q9CWJ7 | |
| Q14016 | |
| Q52LZ5 | |
| Q6KFX4 | |
| Q59FM4 | |
| Q9NR60 | |
| Q3TZ42 | |
| Q8BNQ0 | |
| O88548 | |
| Q6B4I7 | |
| Q6SR89 |
| GO ID | 0005545 |
|---|---|
| 0034186 | |
| 0034185 | |
| 0008035 | |
| 0070506 | |
| 0001530 | |
| 0001875 | |
| 0030169 | |
| 0001786 | |
| 0042803 | |
| 0005215 | |
| 0051856 | |
| 0006702 | |
| 0043534 | |
| 0007155 | |
| 0006707 | |
| 0033344 | |
| 0042632 | |
| 0070508 | |
| 0032497 | |
| 0001935 | |
| 0034384 | |
| 0034375 | |
| 0006629 | |
| 0015920 | |
| 0031663 | |
| 0042157 | |
| 0034383 | |
| 0015914 | |
| 0010886 | |
| 0010595 | |
| 0051000 | |
| 0010867 | |
| 0043654 | |
| 0050764 | |
| 0010899 | |
| 0043691 | |
| 0044281 | |
| 0070328 | |
| 0019048 | |
| 0042060 | |
| 0005901 | |
| 0009986 | |
| 0005737 | |
| 0005887 | |
| 0031528 | |
| 0005886 | |
| 0030301 | |
| 0006869 | |
| 0006910 | |
| 0016021 | |
| 0016020 | |
| 0005319 | |
| 0006694 | |
| 0004872 | |
| 0044419 | |
| 0000299 |
| PIR ID | S36656 |
|---|---|
| JC5533 |
| Swiss-Prot ID | SCRB1_MOUSE |
|---|---|
| SCRB1_HUMAN | |
| SCRB1_RAT | |
| Q4FK30_MOUSE | |
| Q52LZ5_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Membrane | |
| caveola | |
| Plasma membrane |
| IPI ID | IPI00116921 |
|---|---|
| IPI00177968 | |
| IPI00291007 | |
| IPI00375570 | |
| IPI00447020 | |
| IPI00209707 | |
| IPI00815756 | |
| IPI00847893 | |
| IPI00458078 | |
| IPI00856595 | |
| IPI00857130 | |
| IPI00856356 | |
| IPI00464469 |
| Mouse chromosome position | 5 64.11 cM |
|---|---|
| 5 68.0 cM |
| Rat chromosome position | 12q15-q16 |
|---|
| Homologene ID | 21132 |
|---|
| MGI ID | 893578 |
|---|
| RGD ID | 2302 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|