| URN | urn:agi-llid:7424 |
|---|---|
| Total Entities | 0 |
| Connectivity | 565 |
| Name | Vegfc |
| Description | vascular endothelial growth factor C |
| Notes | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth [RGD] |
| Ariadne Ontology | GF |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | chemoattractant activity |
|---|---|
| growth factor activity | |
| vascular endothelial growth factor receptor 3 binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| platelet alpha granule lumen | |
| extracellular space |
| GO Biological Process | regulation of vascular endothelial growth factor receptor signaling pathway |
|---|---|
| signal transduction | |
| vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of protein autophosphorylation | |
| positive regulation of protein secretion | |
| positive regulation of cell division | |
| positive regulation of cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of neuroblast proliferation | |
| positive regulation of mast cell chemotaxis | |
| positive regulation of blood vessel endothelial cell migration | |
| cell differentiation | |
| platelet activation | |
| platelet degranulation | |
| substrate-dependent cell migration | |
| response to drug | |
| positive chemotaxis | |
| induction of positive chemotaxis | |
| regulation of angiogenesis | |
| positive regulation of lymphangiogenesis | |
| multicellular organismal development | |
| angiogenesis | |
| organ morphogenesis | |
| morphogenesis of embryonic epithelium | |
| blood coagulation | |
| negative regulation of blood pressure |
| Pathway | VEGFR -> AP-1/CREB/MYC signaling |
|---|---|
| VEGFR -> FOXO3A signaling | |
| VEGFR -> CTNNB signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| VEGFR -> CTNND signaling | |
| VEGFR -> STAT signaling | |
| VEGFC/CTNNB Expression Target | |
| VEGFC/ATF Expression Target | |
| drug-gene, gene-chemical, gene-gene interaction pathway | |
| losartan_expanded2 | |
| losartan_expanded3 | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| vascular endothelial growth factor signaling pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway |
| Group | GF |
|---|---|
| regulation of vascular endothelial growth factor receptor signaling pathway | |
| signal transduction | |
| vascular endothelial growth factor receptor signaling pathway | |
| positive regulation of protein autophosphorylation | |
| positive regulation of protein secretion | |
| positive regulation of cell division | |
| positive regulation of cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of neuroblast proliferation | |
| positive regulation of mast cell chemotaxis | |
| positive regulation of blood vessel endothelial cell migration | |
| cell differentiation | |
| platelet activation | |
| platelet degranulation | |
| substrate-dependent cell migration | |
| response to drug | |
| positive chemotaxis | |
| induction of positive chemotaxis | |
| regulation of angiogenesis | |
| positive regulation of lymphangiogenesis | |
| multicellular organismal development | |
| angiogenesis | |
| organ morphogenesis | |
| morphogenesis of embryonic epithelium | |
| blood coagulation | |
| negative regulation of blood pressure | |
| chemoattractant activity | |
| growth factor activity | |
| vascular endothelial growth factor receptor 3 binding | |
| membrane | |
| extracellular region | |
| platelet alpha granule lumen | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 7424 |
|---|
| Hugo ID | 12682 |
|---|
| Human chromosome position | 4q34.3 |
|---|---|
| 4q34.1-q34.3 |
| LocusLink ID | 7424 |
|---|---|
| 22341 | |
| 114111 | |
| 102311 |
| Alias | VRP |
|---|---|
| Flt4-L | |
| vascular endothelial growth factor C | |
| VEGF-C | |
| FLT4 ligand DHM | |
| vascular endothelial growth factor-related protein | |
| AW228853 | |
| flt4 ligand | |
| vascular endothelial growth factor C isoform 129 | |
| vascular endothelial growth factor C isoform 184 | |
| Vegfc | |
| VEGC_HUMAN | |
| VEGC | |
| Vascular endothelial growth factor related protein | |
| Flt4-Ls | |
| Vascular endothelial growth factor related protein | |
| Vascular endothelial growth factor C precursor | |
| expressed sequence AW228853 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601528 |
|---|
| Unigene ID | Hs.435215 |
|---|---|
| Mm.1402 | |
| Rn.6913 |
| KEGG ID | hsa:7424 |
|---|---|
| mmu:22341 | |
| rno:114111 |
| Swiss-Prot Accession | P49767 |
|---|---|
| P97953 | |
| O35757 | |
| B2R9Q8 | |
| Q543R6 | |
| Q91ZE3 | |
| Q6FH59 |
| GO ID | 0042056 |
|---|---|
| 0008083 | |
| 0043185 | |
| 0001525 | |
| 0007596 | |
| 0050930 | |
| 0016331 | |
| 0045776 | |
| 0009887 | |
| 0030168 | |
| 0002576 | |
| 0050918 | |
| 0043536 | |
| 0051781 | |
| 0008284 | |
| 0050679 | |
| 0060754 | |
| 0002052 | |
| 0031954 | |
| 0050714 | |
| 0030947 | |
| 0042493 | |
| 0007165 | |
| 0006929 | |
| 0048010 | |
| 0005576 | |
| 0005615 | |
| 0016020 | |
| 0031093 | |
| 0030154 | |
| 0007275 | |
| 1901492 | |
| 0045765 | |
| 0008283 | |
| 0001946 | |
| 0000074 |
| PIR ID | S69207 |
|---|
| Swiss-Prot ID | VEGFC_HUMAN |
|---|---|
| VEGFC_MOUSE | |
| VEGFC_RAT | |
| B2R9Q8_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00028076 |
|---|---|
| IPI00131065 | |
| IPI00209790 |
| Mouse chromosome position | 8 |
|---|---|
| 8 B3 |
| Rat chromosome position | 16p11 |
|---|
| Homologene ID | 3962 |
|---|
| MGI ID | 109124 |
|---|---|
| 2142780 |
| RGD ID | 619800 |
|---|
| Primary Cell Localization | Extracellular |
|---|
| KEGG pathway | Cytokine-cytokine receptor interaction |
|---|---|
| Focal adhesion |