| URN | urn:agi-llid:1231 |
|---|---|
| Total Entities | 0 |
| Connectivity | 811 |
| Name | Ccr2 |
| Description | chemokine (C-C motif) receptor 2 |
| Notes | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq] |
| Ariadne Ontology | GPCR-Gq-iCR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | cytokine binding |
|---|---|
| CCR2 chemokine receptor binding | |
| chemokine binding | |
| C-C chemokine binding | |
| chemokine (C-C motif) ligand 7 binding | |
| chemokine (C-C motif) ligand 2 binding | |
| chemokine (C-C motif) ligand 12 binding | |
| protein homodimerization activity | |
| G-protein coupled receptor activity | |
| chemokine receptor activity | |
| C-C chemokine receptor activity | |
| signal transducer activity |
| GO Cellular Component | membrane |
|---|---|
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| perikaryon | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| dendrite | |
| neuronal cell body |
| GO Biological Process | virus-host interaction |
|---|---|
| cellular homeostasis | |
| positive regulation of MAPK cascade | |
| signal transduction | |
| JAK-STAT cascade | |
| cytokine-mediated signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| chemokine-mediated signaling pathway | |
| positive regulation of tumor necrosis factor biosynthetic process | |
| negative regulation of adenylate cyclase activity | |
| negative regulation of eosinophil degranulation | |
| positive regulation of alpha-beta T cell proliferation | |
| positive regulation of T cell activation | |
| positive regulation of T-helper 1 cell differentiation | |
| positive regulation of hematopoietic stem cell migration | |
| positive regulation of astrocyte chemotaxis | |
| positive regulation of monocyte chemotaxis | |
| positive regulation of T cell chemotaxis | |
| positive regulation of monocyte extravasation | |
| positive regulation of CD8-positive, alpha-beta T cell extravasation | |
| regulation of cell migration | |
| cellular calcium ion homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| dendritic cell chemotaxis | |
| T-helper 17 cell chemotaxis | |
| immune response | |
| positive regulation of immune complex clearance by monocytes and macrophages | |
| humoral immune response | |
| inflammatory response to antigenic stimulus | |
| innate immune response | |
| positive regulation of T-helper 1 type immune response | |
| negative regulation of type 2 immune response | |
| chemotaxis | |
| response to hypoxia | |
| response to wounding | |
| cellular defense response | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| wound healing involved in inflammatory response | |
| negative regulation of angiogenesis | |
| regulation of vascular endothelial growth factor production | |
| positive regulation of interleukin-2 production | |
| positive regulation of interferon-gamma production | |
| angiogenesis | |
| hemopoiesis | |
| blood vessel remodeling | |
| sensory perception of pain | |
| apoptotic cell clearance |
| Pathway | CCR2/5 -> STAT signaling |
|---|---|
| CCL2 Expression Targets | |
| CCL7 Expression Target | |
| CCL8 Expression Targets | |
| CCL11 Expression Targets | |
| CCL16 Expression Targets | |
| IL8 Expression Targets | |
| drug-gene, gene-chemical, gene-gene interaction pathway | |
| losartan_expanded2 | |
| losartan_expanded3 | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway |
| Group | GPCR-Gq-iCR |
|---|---|
| virus-host interaction | |
| cellular homeostasis | |
| positive regulation of MAPK cascade | |
| signal transduction | |
| JAK-STAT cascade | |
| cytokine-mediated signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| chemokine-mediated signaling pathway | |
| positive regulation of tumor necrosis factor biosynthetic process | |
| negative regulation of adenylate cyclase activity | |
| negative regulation of eosinophil degranulation | |
| positive regulation of alpha-beta T cell proliferation | |
| positive regulation of T cell activation | |
| positive regulation of T-helper 1 cell differentiation | |
| positive regulation of hematopoietic stem cell migration | |
| positive regulation of astrocyte chemotaxis | |
| positive regulation of monocyte chemotaxis | |
| positive regulation of T cell chemotaxis | |
| positive regulation of monocyte extravasation | |
| positive regulation of CD8-positive, alpha-beta T cell extravasation | |
| regulation of cell migration | |
| cellular calcium ion homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| dendritic cell chemotaxis | |
| T-helper 17 cell chemotaxis | |
| immune response | |
| positive regulation of immune complex clearance by monocytes and macrophages | |
| humoral immune response | |
| inflammatory response to antigenic stimulus | |
| innate immune response | |
| positive regulation of T-helper 1 type immune response | |
| negative regulation of type 2 immune response | |
| chemotaxis | |
| response to hypoxia | |
| response to wounding | |
| cellular defense response | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| wound healing involved in inflammatory response | |
| negative regulation of angiogenesis | |
| regulation of vascular endothelial growth factor production | |
| positive regulation of interleukin-2 production | |
| positive regulation of interferon-gamma production | |
| angiogenesis | |
| hemopoiesis | |
| blood vessel remodeling | |
| sensory perception of pain | |
| apoptotic cell clearance | |
| cytokine binding | |
| CCR2 chemokine receptor binding | |
| chemokine binding | |
| C-C chemokine binding | |
| chemokine (C-C motif) ligand 7 binding | |
| chemokine (C-C motif) ligand 2 binding | |
| chemokine (C-C motif) ligand 12 binding | |
| protein homodimerization activity | |
| G-protein coupled receptor activity | |
| chemokine receptor activity | |
| C-C chemokine receptor activity | |
| signal transducer activity | |
| membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| perikaryon | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| dendrite | |
| neuronal cell body | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1231 |
|---|
| Hugo ID | 1603 |
|---|
| Human chromosome position | 3p21.31 |
|---|
| LocusLink ID | 1231 |
|---|---|
| 729230 | |
| 12772 | |
| 60463 |
| Alias | CKR2 |
|---|---|
| CCR-2 | |
| CCR2A | |
| CCR2B | |
| CD192 | |
| CKR2A | |
| CKR2B | |
| CMKBR2 | |
| MCP-1-R | |
| CC-CKR-2 | |
| hCG_14621 | |
| C-C chemokine receptor type 2 | |
| MCP-1 receptor | |
| monocyte chemotactic protein 1 receptor | |
| monocyte chemoattractant protein 1 receptor | |
| mJe-r | |
| C-C CKR-2 | |
| MIP-1 alphaR | |
| JE/FIC receptor | |
| chemokine (C-C) receptor 2 | |
| chemoattractant protein-1 receptor | |
| C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) | |
| chemokine receptor CCR2 | |
| MGC111760 | |
| FLJ78302 | |
| LOC113395 | |
| LOC235692 | |
| LOC82514 | |
| MGC103828 | |
| LOC653518 | |
| MGC168006 | |
| Monocyte chemoattractant protein-1 receptors | |
| Monocyte chemotactic protein 1 receptors | |
| OTTHUMP00000209947 | |
| OTTHUMP00000209949 | |
| PIR:JC2443 | |
| MCP-1-Rs | |
| CC-CKR II | |
| C-C chemokine receptor 2 | |
| C-C chemokine receptor II | |
| LOC90262 | |
| CCR2 | |
| chemoattractant protein-1 receptors | |
| C-C CKR II | |
| chemokine (C-C motif) receptor 2 | |
| chemokine (C-C) receptor II | |
| chemokine (C-C) receptor 2, splice form B | |
| chemokine (C-C) receptor 2, splice form A | |
| chemokine (C-C motif) receptor II | |
| chemokine (C-C motif) receptor 2-like | |
| CKR2_HUMAN |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601267 |
|---|
| Unigene ID | Hs.511794 |
|---|---|
| Hs.705362 | |
| Mm.6272 | |
| Rn.211983 |
| KEGG ID | hsa:729230 |
|---|---|
| mmu:12772 | |
| rno:60463 |
| Swiss-Prot Accession | P41597 |
|---|---|
| P51683 | |
| Q3TRK1 | |
| Q543S8 | |
| O55193 | |
| Q61172 | |
| A0AVQ3 | |
| B2RMT0 | |
| Q4VBL2 | |
| O95950 | |
| Q3U3U0 |
| GO ID | 0016493 |
|---|---|
| 0031727 | |
| 0004950 | |
| 0042803 | |
| 0007259 | |
| 0035705 | |
| 0001974 | |
| 0006874 | |
| 0006968 | |
| 0019725 | |
| 0070098 | |
| 0006935 | |
| 0019221 | |
| 0002407 | |
| 0007204 | |
| 0006955 | |
| 0006954 | |
| 0045087 | |
| 0007194 | |
| 0016525 | |
| 0043310 | |
| 0002829 | |
| 2000451 | |
| 0050870 | |
| 0010820 | |
| 0002827 | |
| 0046641 | |
| 2000464 | |
| 2000473 | |
| 0090265 | |
| 0050729 | |
| 0032729 | |
| 0032743 | |
| 0090026 | |
| 2000439 | |
| 0042535 | |
| 0010574 | |
| 0009611 | |
| 0019048 | |
| 0005737 | |
| 0005829 | |
| 0030425 | |
| 0016021 | |
| 0005887 | |
| 0043025 | |
| 0043204 | |
| 0048471 | |
| 0005886 | |
| 0019957 | |
| 0004930 | |
| 0035716 | |
| 0035715 | |
| 0035717 | |
| 0019956 | |
| 0019955 | |
| 0004871 | |
| 0007186 | |
| 0001525 | |
| 0043277 | |
| 0030097 | |
| 0006959 | |
| 0043410 | |
| 0045627 | |
| 0030334 | |
| 0019233 | |
| 0007165 | |
| 0002246 | |
| 0016020 | |
| 0002437 | |
| 0001666 | |
| 0004872 | |
| 0044419 | |
| 0005625 | |
| 0010759 |
| PIR ID | I38450 |
|---|---|
| JC2443 |
| Swiss-Prot ID | CCR2_MOUSE |
|---|---|
| CCR2_HUMAN | |
| CCR2_RAT | |
| Q3TRK1_MOUSE | |
| Q4VBL2_HUMAN | |
| Q543S8_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00125256 |
|---|---|
| IPI00015137 | |
| IPI00218945 | |
| IPI00196054 |
| Mouse chromosome position | 9 71.9 cM |
|---|
| Rat chromosome position | 8q32 |
|---|
| Homologene ID | 537 |
|---|
| MGI ID | 106185 |
|---|
| RGD ID | 620876 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|