Protein Fos

URN	urn:agi-llid:2353
Total Entities	0
Connectivity	3493
Name	Fos
Description	FBJ murine osteosarcoma viral oncogene homolog
Notes	The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq]

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Ariadne Ontology	Jun-Fos
	Oncogenes
	Secreted proteins
	Biofluids assayable substances

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GO Molecular Function	transcription factor binding
	protein heterodimerization activity
	R-SMAD binding
	DNA binding
	sequence-specific DNA binding
	double-stranded DNA binding
	transcription regulatory region DNA binding
	sequence-specific DNA binding transcription factor activity

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GO Cellular Component	membrane
	nucleoplasm
	nucleolus
	transcription factor complex
	nucleus
	neuron projection

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GO Biological Process	female pregnancy
	cellular response to extracellular stimulus
	SMAD protein signal transduction
	stress-activated MAPK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 3 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	MyD88-independent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	TRIF-dependent toll-like receptor signaling pathway
	Toll signaling pathway
	transforming growth factor beta receptor signaling pathway
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter
	regulation of sequence-specific DNA binding transcription factor activity
	transcription from RNA polymerase II promoter
	DNA methylation
	cellular response to reactive oxygen species
	cellular response to hormone stimulus
	cellular response to calcium ion
	innate immune response
	response to stress
	response to drug
	response to toxin
	response to cytokine stimulus
	response to organic cyclic compound
	response to lipopolysaccharide
	response to progesterone stimulus
	response to corticosterone stimulus
	response to cAMP
	response to cold
	inflammatory response
	response to mechanical stimulus
	conditioned taste aversion
	sleep
	response to gravity
	response to light stimulus
	aging
	nervous system development

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Pathway	Cell Cycle
	FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
	PDGFR -> AP-1/MYC signaling
	VEGFR -> AP-1/CREB/MYC signaling
	HGFR -> AP-1/CREB/MYC signaling
	AngiopoietinR -> AP-1 signaling
	ErythropoietinR -> AP-1/CREB/MYC signaling
	ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
	EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
	EctodysplasinR -> AP-1 signaling
	NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
	TNFR -> AP-1/ATF/TP53 signaling
	TNFRSF1A -> AP-1/ATF/TP53 signaling
	T-cell receptor -> AP-1 signaling
	TGFBR -> AP-1 signaling
	TLR -> AP-1 signaling
	EGFR -> AP-1/ATF2 signaling
	NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
	ICAM1 -> AP-1/CREB/ELK-SRF signaling
	FibronectinR -> AP-1/ELK-SRF/SREBF signaling
	B-cell receptor -> AP-1 signaling
	CD19 -> AP-1/ELK-SRF signaling
	ErythropoietinR -> ELK-SRF/FOS signaling
	CannabinoidR -> AP-1/EGR signaling
	DopamineR2 -> AP-1/CREB/ELK-SRF signaling
	SerotoninR1 -> FOS signaling
	PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling
	OxytocinR -> ELK-SRF/GATA/AP-1 signaling
	NeurotensinR -> ELK-SRF/AP-1/EGR signaling
	AdenosineR -> AP-1 signaling
	VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
	ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling
	EDG3/5 -> AP-1/ELK-SRF signaling
	EndothelinRb -> AP-1/CREB/ELK-SRF signaling
	ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling
	EndothelinRa -> AP-1/CREB signaling
	VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
	ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
	Clozapine-Induced Granulocytopenia
	TGFB3-TGFBR2 Expression Targets
	TGFB2-TGFBR2 Expression Targets
	TGFB1-TGFBR2 Expression Targets
	TLR5 Expression Targets
	TLR7 Expression Targets
	TLR9 Expression Targets
	TLR1/2/6 Expression Targets
	FASLG Expression Targets
	BDNF Expression Targets
	NTF3 Expression Targets
	NTF4 Expression Targets
	TNFSF13 Expression Targets
	TNFSF13B Expression Targets
	EDA Expression Targets
	TNFSF10 Expression Targets
	LTA Expression Targets
	TNFSF14 Expression Targets
	TNF/STAT Expression Targets
	NGF/AP-1/TP53/MYC Expression Targets
	NGF/SMAD3/NF-kB Expression Targets
	CD40LG/ATF2/AP-1/TP53/E2F Expression Targets
	ICAM1 Expression Targets
	NCAM1 Expression Targets
	Gamma Globulins Expression Targets
	CD247 Expression Targets
	FCGR3A Expression Targets
	PLAU/ELK-SRF/AP-1 Expression Targets
	PLAU/STAT1 Expression Targets
	CD19 Expression Targets
	CD81 Expression Targets
	IL13 Expression Targets
	IL6 Expression Targets
	IL7 Expression Targets
	IL2 Expression Targets
	IL3 Expression Targets
	LIF Expression Targets
	CTF1 Expression Targets
	Erythropoietin/STAT Expression Targets
	Erythropoietin/ELK-SRF Expression Targets
	Erythropoietin/NF-kB Expression Targets
	GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets
	GH1-GHR/STAT Expression Targets
	PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets
	PRL-GHR/STAT Expression Targets
	GH1-PRLR Expression Targets
	PRL-PRLR Expression Targets
	IFNG-IFNR Expression Targets
	Leptin/ELK-SRF Expression Targets
	Leptin/STAT Expression Targets
	CXCL12 Expression Targets
	NPY Expression Targets
	Dopamine/Gi Expression Targets
	Dronabinol/Anandamide Expression Targets
	GNRH2 Expression Targets
	S100B Expression Targets
	Acetylcholine Expression Targets
	PTPRJ Expression Targets
	AREG/AP-1 Expression Targets
	EREG/AP-1/ATF Expression Targets
	HBEGF/AP-1/ATF Expression Targets
	NRG1/Catenin Expression Targets
	NRG1/STAT Expression Targets
	NRG1/AP-1/ATF Expression Targets
	NRG1/EP300/ETS/ETV/SP1 Expression Targets
	TGFA/CTNNB/CTNND Expression Targets
	TGFA/STAT Expression Targets
	FGF1/STAT Expression Targets
	FGF18/STAT Expression Targets
	CSF1/STAT Expression Targets
	KITLG/STAT Expression Targets
	VEGFA/CTNNB/CTNND Expression Targets
	VEGFA/ATF/CREB/ELK-SRF Expression Targets
	ANGPT2/STAT Expression Targets
	GDNF/HSF1 Expression Targets
	IGF2/STAT Expression Targets
	CTGF/AP-1/CREB/MYC Expression Targets
	Erythropoietin/AP-1/MYC/CREB Expression Targets
	FLT3LG/AP-1/CREB/CREBBP Expression Targets
	GAS6/AP-1/CREB Expression Targets
	PGF/AP-1/CREB/CREBBP/MYC Expression Targets
	Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
	NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
	FGF4/AP-1/MYC Expression Targets
	FGF7/AP-1/CREB/CREBBP/MYC Expression Targets
	FGF9/AP-1/CREB/MYC Expression Targets
	FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
	FGF18/AP-1/CREB Expression Targets
	CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
	PDGFB/AP-1/CREB/MYC Expression Target
	PDGFD/AP-1 Expression Targets
	ANGPT2/AP-1/CREBBP/MYC Expression Targets
	FIGF/AP-1 Expression Target
	F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
	Thromboxane A2 Expression Targets
	F2 -> STAT1/NF-kB Expression Targets
	PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
	PLG -> STAT1/NF-kB Expression Targets
	Serotonin/Gq Expression Targets
	Epinephrine/Gq Expression Targets
	Adenosine Expression Targets
	Prostaglandin F Expression Targets
	AVP/Gq -> STAT Expression Targets
	CCK Expression Targets
	AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
	GNRH1 Expression Targets
	Morphine Expression Targets
	NTS Expression Targets
	GAST Expression Targets
	S1P Expression Targets
	TAC1 Expression Targets
	PGE1 Expression Targets
	Epinephrine/Gs Expression Targets
	Noradrenaline/Gs Expression Targets
	VIP Expression Targets
	Dopamine/Gs Expression Targets
	GCG Expression Targets
	AVP/Gs -> STAT Expression Targets
	FSHR Expression Targets
	AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
	Serotonin/Gs Expression Targets
	Noreadrenaline/Gq Expression Targets
	POMC Expression Targets
	EDN1 Expression Targets
	EDN3 Expression Targets
	ADCYAP1 Expression Targets
	IL16/AP-1 Expression Targets
	CD8/AP-1 Expression Targets
	CD80/AP-1 Expression Targets
	CD86/AP-1 Expression Targets
	CD72/AP-1 Expression Targets
	PDCD1/AP-1 Expression Targets
	TCR/STAT Expression Targets
	TCR/AP-1 Expression Targets
	FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	HGF/STAT Expression Targets
	IGF1/STAT Expression Targets
	Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	Insulin/STAT Expression Targets
	VEGFA/STAT Expression Targets
	FGF2/STAT Expression Targets
	IL1A Expression Targets
	IL1B/PGE2 Expression Targets
	PAF Expression Targets
	AGT/CREB Expression Targets
	AGT/STAT Expression Targets
	CSF2/STAT Expression Targets
	EGF/AP-1/ATF Expression Targets
	EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	EGF/MEF/MYOD/NFATC Expression Targets
	EGF/STAT Expression Targets
	HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
	IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	IGF1/MEF/MYOD/MYOG Expression Targets
	IL1B/NO Expression Targets
	Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets
	Insulin/MEF/MYOD Expression Targets
	KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
	LPA Expression Targets
	PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets
	PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
	PDGF/STAT Expression Targets
	TGFA/AP-1/ATF Expression Targets
	TGFB1-TGFBR1/AP-1 Expression Targets
	TLR4/AP-1 Expression Targets
	TLR4/AP-1/EGR1/HIF1A Expression Targets
	TNF/AP-1 Expression Targets
	VEGFA/AP-1/CREBBP/MYC Expression Targets
	IL1B Expression Targets
	BTC/AP-1/ATF/CREB Expression Targets
	EGF/CTNN Expression Targets
	drug-gene, gene-chemical, gene-gene interaction pathway
	losartan_expanded2
	losartan_expanded3
	losartan-gene, gene-chemical, gene-gene interaction pathway
	losartan-gene, gene-chemical, gene-gene interaction pathway
	metformin-gene, gene-chemical, gene-gene interaction pathway
	losartan-gene, gene-chemical, gene-gene interaction pathway

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Group	Jun-Fos
	Oncogenes
	female pregnancy
	cellular response to extracellular stimulus
	SMAD protein signal transduction
	stress-activated MAPK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 3 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	MyD88-independent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	TRIF-dependent toll-like receptor signaling pathway
	Toll signaling pathway
	transforming growth factor beta receptor signaling pathway
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter
	regulation of sequence-specific DNA binding transcription factor activity
	transcription from RNA polymerase II promoter
	DNA methylation
	cellular response to reactive oxygen species
	cellular response to hormone stimulus
	cellular response to calcium ion
	innate immune response
	response to stress
	response to drug
	response to toxin
	response to cytokine stimulus
	response to organic cyclic compound
	response to lipopolysaccharide
	response to progesterone stimulus
	response to corticosterone stimulus
	response to cAMP
	response to cold
	inflammatory response
	response to mechanical stimulus
	conditioned taste aversion
	sleep
	response to gravity
	response to light stimulus
	aging
	nervous system development
	transcription factor binding
	protein heterodimerization activity
	R-SMAD binding
	DNA binding
	sequence-specific DNA binding
	double-stranded DNA binding
	transcription regulatory region DNA binding
	sequence-specific DNA binding transcription factor activity
	membrane
	nucleoplasm
	nucleolus
	transcription factor complex
	nucleus
	neuron projection
	Secreted proteins
	Biofluids assayable substances

---

MedScan ID	2353

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Hugo ID	3796

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Human chromosome position	14q24.3

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GenBank ID	NC_000014
	NM_005252
	NP_005243
	NG_029673
	NC_018925
	AC_000146
	AB022275
	BAA87920
	AB022276
	BAA87921
	AF111167
	AAC98315
	AY212879
	AAO21129
	CH471061
	EAW81227
	EAW81228
	EAW81229
	HI574162
	CBX47570
	K00650
	AAA52471
	V01512
	CAA24756
	AK097379
	BAG53458
	AK290907
	BAF83596
	AK291326
	BAF84015
	AK298659
	BAG60827
	BC004490
	AAH04490
	BX647104
	CR541785
	CAG46584
	CR542267
	CAG47063
	S65138
	AAB20306
	P01100
	DQ893444
	ABM84370
	DQ896750
	ABM87749
	NC_000078
	NM_010234
	NP_034364
	AC_000034
	AC159244
	CH466590
	EDL02869
	EDL02870
	EDL02871
	J00370
	AAA96699
	M23768
	V00727
	CAA24105
	AK154418
	BAE32571
	AK159688
	AY423854
	AAR00345
	BC013242
	BC029814
	AAH29814
	P01101
	NC_005105
	NM_022197
	NP_071533
	AC_000074
	AF126534
	AF277645
	AAG47951
	AY780201
	AAV33852
	AY780202
	AAV33853
	AY780203
	AAV33854
	AY786174
	AAV41063
	AY828998
	AAW65541
	AY828999
	AAW65542
	CH473982
	EDL81573
	EDL81574
	EDL81575
	DQ089699
	AAZ13764
	M34001
	AAA42348
	U02631
	FQ225996
	FQ228884
	X06769
	CAA29937
	P12841
	NT_026437
	NW_001838113
	NW_925561
	AC_000057
	CR612516
	CR620080
	Q6FG41
	Q76MY9
	Q76MZ0
	NT_039551
	NW_001030502
	Q3U463
	Q6TDG4
	NW_001084846
	NW_047762
	Q5G6W2
	Q5G6W3
	Q5U7E3
	Q5U873
	Q5U874
	Q5U875
	Q63752
	Q9EQC2

---

LocusLink ID	2353
	14281
	314322

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Alias	p55
	AP-1
	C-FOS
	proto-oncogene c-Fos
	activator protein 1
	cellular oncogene c-fos
	G0/G1 switch regulatory protein 7
	FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
	cFos
	D12Rfj1
	cellular oncogene fos
	proto-oncogene protein c-fos
	c-fos oncogene
	proto-oncogene cFOS
	FBJ murine osteosarcoma viral oncogene homolog
	v-fos FBJ murine osteosarcoma viral oncogene homolog
	G0S7
	protooncogene protein c-Fos
	G0S7 proteins
	LOC196935
	oncogene Fos
	OTTMUSP00000021331
	P55-C-FOS proto-oncogene protein
	proto-oncogene Fos
	Foswb
	transcription factor c-Fos
	transforming protein Fos
	v-Fos
	v-Fos oncogene
	wb-Fos
	protooncogene Fos
	FBJ murine osteosarcoma viral
	wbFos
	FBJ murine osteosarcoma viral (v-fos) oncogene homolog
	FBJ osteosarcoma oncogene
	Fos
	FOS_HUMAN
	Fos-wb
	D12Rfj I
	v-Fos oncogene homolog

---

Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus

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OMIM ID	164810

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Unigene ID	Hs.25647
	Mm.246513
	Rn.103750

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KEGG ID	hsa:2353
	mmu:14281
	rno:314322

---

Swiss-Prot Accession	P01100
	Q6FG41
	P01101
	P12841
	P18849
	Q76MY9
	Q76MZ0
	Q3U463
	Q6TDG4
	Q5G6W2
	Q5G6W3
	Q5U7E3
	Q5U873
	Q5U874
	Q5U875
	Q63752
	Q9EQC2
	Q4FDN1

---

GO ID	0070412
	0003690
	0043565
	0003700
	0044212
	0006306
	0002755
	0002756
	0060395
	0035666
	0008063
	0007568
	0071277
	0031668
	0032870
	0034614
	0001661
	0007565
	0006954
	0045087
	0007399
	0045944
	0045893
	0051090
	0006357
	0051591
	0009409
	0051412
	0034097
	0042493
	0009629
	0009416
	0032496
	0009612
	0014070
	0032570
	0009636
	0030431
	0051403
	0034130
	0034134
	0034138
	0034142
	0002224
	0006366
	0007179
	0005730
	0005654
	0005634
	0005667
	0003677
	0046982
	0008134
	0006355
	0016020
	0043005
	0006950
	0010843
	0003704
	0045941
	0051789
	0019717
	0005624

---

PIR ID	A01343
	A01342
	E34223
	A28263

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Swiss-Prot ID	FOS_MOUSE
	FOS_HUMAN
	FOS_RAT
	Q6FG41_HUMAN

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Cell Localization	Nucleus

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IPI ID	IPI00131985
	IPI00033008
	IPI00368000

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Mouse chromosome position	12 40.0 cM

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Rat chromosome position	6q31

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Homologene ID	3844

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MGI ID	95574

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RGD ID	2626

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Primary Cell Localization	Nucleus

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