| URN | urn:agi-llid:7351 |
|---|---|
| Total Entities | 0 |
| Connectivity | 710 |
| Name | Ucp2 |
| Description | uncoupling protein 2 (mitochondrial, proton carrier) |
| Notes | Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq] |
| Ariadne Ontology | Respiratory chain |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Cellular Component | membrane |
|---|---|
| mitochondrial membrane | |
| mitochondrial inner membrane | |
| integral to membrane | |
| mitochondrion |
| GO Biological Process | respiratory electron transport chain |
|---|---|
| cellular response to hormone stimulus | |
| cellular response to insulin stimulus | |
| response to superoxide | |
| response to glucose stimulus | |
| response to fatty acid | |
| response to hypoxia | |
| transport | |
| proton transport | |
| mitochondrial transport | |
| small molecule metabolic process |
| Pathway | PRL-GHR/STAT Expression Targets |
|---|---|
| PRL-PRLR Expression Targets | |
| AGT/STAT Expression Targets | |
| drug-gene, gene-chemical, gene-gene interaction pathway | |
| losartan_expanded2 | |
| losartan_expanded3 | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway |
| Group | Respiratory chain |
|---|---|
| respiratory electron transport chain | |
| cellular response to hormone stimulus | |
| cellular response to insulin stimulus | |
| response to superoxide | |
| response to glucose stimulus | |
| response to fatty acid | |
| response to hypoxia | |
| transport | |
| proton transport | |
| mitochondrial transport | |
| small molecule metabolic process | |
| membrane | |
| mitochondrial membrane | |
| mitochondrial inner membrane | |
| integral to membrane | |
| mitochondrion | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 7351 |
|---|
| Hugo ID | 12518 |
|---|
| Human chromosome position | 11q13 |
|---|
| LocusLink ID | 7351 |
|---|---|
| 22228 | |
| 54315 |
| Alias | UCPH |
|---|---|
| BMIQ4 | |
| SLC25A8 | |
| mitochondrial uncoupling protein 2 | |
| UCP 2 | |
| solute carrier family 25 member 8 | |
| uncoupling protein 2, mitochondrial | |
| Uncoupling protein II | |
| uncoupling protein 2 (mitochondrial, proton carrier) | |
| uncoupling protein 2 | |
| Ucp2 | |
| LOC119829 | |
| OTTMUSP00000026187 | |
| OTTMUSP00000026186 | |
| Mitochondrial uncoupling protein II | |
| AW108044 | |
| Uncoupling protein-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601693 |
|---|---|
| 607447 | |
| 606641 | |
| 601665 |
| Unigene ID | Hs.80658 |
|---|---|
| Mm.171378 | |
| Rn.13333 |
| KEGG ID | hsa:7351 |
|---|---|
| mmu:22228 | |
| rno:54315 |
| Swiss-Prot Accession | P55851 |
|---|---|
| P70406 | |
| Q549J5 | |
| Q8CBU0 | |
| P56500 | |
| O70178 | |
| O88183 | |
| Q6GST1 | |
| O88285 | |
| Q4PJH8 | |
| Q53HM3 | |
| Q9R1U6 | |
| Q9R246 |
| GO ID | 0032869 |
|---|---|
| 0006839 | |
| 0015992 | |
| 0022904 | |
| 0070542 | |
| 0009749 | |
| 0001666 | |
| 0000303 | |
| 0044281 | |
| 0006810 | |
| 0016021 | |
| 0005743 | |
| 0016020 | |
| 0031966 | |
| 0005739 | |
| 0032870 | |
| 0055085 |
| Swiss-Prot ID | UCP2_RAT |
|---|---|
| UCP2_MOUSE | |
| UCP2_HUMAN | |
| Q8CBU0_MOUSE | |
| Q549J5_MOUSE |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00324565 |
|---|---|
| IPI00109175 | |
| IPI00026573 | |
| IPI00648341 | |
| IPI00858064 | |
| IPI00858033 | |
| IPI00857900 | |
| IPI00857609 |
| Mouse chromosome position | 7 50.0 cM |
|---|
| Rat chromosome position | 1q32 |
|---|
| Homologene ID | 2516 |
|---|
| MGI ID | 109354 |
|---|
| RGD ID | 3932 |
|---|
| Primary Cell Localization | Mitochondria |
|---|