| URN | urn:agi-llid:2868 |
|---|---|
| Total Entities | 0 |
| Connectivity | 72 |
| Name | GRK4 |
| Description | G protein-coupled receptor kinase 4 |
| Notes | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq] |
| Ariadne Ontology | GRK |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| rhodopsin kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| cell cortex | |
| dendrite | |
| neuronal cell body |
| GO Biological Process | regulation of G-protein coupled receptor protein signaling pathway |
|---|---|
| desensitization of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| signal transduction | |
| receptor internalization | |
| G-protein coupled receptor internalization | |
| protein phosphorylation | |
| phosphorylation |
| Pathway | peripheral dopamine signaling pathway |
|---|---|
| kinin signaling pathway first | |
| kinin signaling pathway | |
| kinin signaling pathway |
| Group | GRK |
|---|---|
| regulation of G-protein coupled receptor protein signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| signal transduction | |
| receptor internalization | |
| G-protein coupled receptor internalization | |
| protein phosphorylation | |
| phosphorylation | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| rhodopsin kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity | |
| cytoplasm | |
| cytosol | |
| cell cortex | |
| dendrite | |
| neuronal cell body | |
| Biofluids assayable substances |
| MedScan ID | 2868 |
|---|
| Hugo ID | 4543 |
|---|
| Human chromosome position | 4p16.3 |
|---|
| LocusLink ID | 2868 |
|---|---|
| 14772 | |
| 59077 |
| Alias | IT11 |
|---|---|
| GPRK4 | |
| GRK4a | |
| GPRK2L | |
| G protein-coupled receptor kinase 4 | |
| ITI1 | |
| GRK | |
| A830025H08Rik | |
| g protein-coupled receptor kinase GRK4 | |
| G protein-coupled receptor kinase 2, groucho gene related | |
| OTTMUSP00000026886 | |
| GPRK4 kinase | |
| IT-11 | |
| ITI I | |
| OTTHUMP00000216993 | |
| GRK4 | |
| OTTMUSP00000026887 | |
| G protein-coupled receptor kinase 2 (Drosophila)-like | |
| G protein-coupled receptor kinase IV | |
| A830025H08Rik(2) | |
| G protein receptor kinase 4 | |
| G protein-coupled receptor kinase 2-like | |
| A830025H08 | |
| G protein-coupled receptor kinase 2-like (Drosophila) | |
| G protein coupled receptor kinase 4 | |
| G-protein coupled receptor kinase 4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 137026 |
|---|
| Unigene ID | Hs.32959 |
|---|---|
| Mm.117076 | |
| Rn.54517 |
| KEGG ID | hsa:2868 |
|---|---|
| mmu:14772 | |
| rno:59077 |
| Swiss-Prot Accession | P32298 |
|---|---|
| O70291 | |
| Q8BP13 | |
| P70507 | |
| P70508 | |
| O00641 | |
| O00642 | |
| Q13293 | |
| Q13294 | |
| Q13295 | |
| Q14453 | |
| Q14725 | |
| Q15313 | |
| Q15314 | |
| Q15315 | |
| Q15316 | |
| Q17RH6 | |
| Q53EQ8 | |
| Q3V151 | |
| Q9D203 |
| EC Number | 2.7.11.16 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004703 | |
| 0050254 | |
| 0002031 | |
| 0031623 | |
| 0008277 | |
| 0007165 | |
| 0038032 | |
| 0005938 | |
| 0005829 | |
| 0030425 | |
| 0043025 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0004674 | |
| 0016740 | |
| 0016772 | |
| 0002029 | |
| 0016310 | |
| 0006468 | |
| 0005737 | |
| 0004871 | |
| 0004872 |
| PIR ID | I54326 |
|---|---|
| JC2127 |
| Swiss-Prot ID | GRK4_RAT |
|---|---|
| GRK4_HUMAN | |
| GRK4_MOUSE | |
| Q8BP13_MOUSE | |
| Q3V151_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| cell cortex |
| IPI ID | IPI00189571 |
|---|---|
| IPI00332016 | |
| IPI00180426 | |
| IPI00182614 | |
| IPI00217944 | |
| IPI00337306 | |
| IPI00116586 | |
| IPI00134048 | |
| IPI00828669 | |
| IPI00857205 |
| Mouse chromosome position | 5 20.0 cM |
|---|
| Rat chromosome position | 14q21 |
|---|
| Homologene ID | 23158 |
|---|
| MGI ID | 95801 |
|---|
| RGD ID | 61858 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|