Elsevier Inc. des-Arg-kinins ---> vasodilation vasodilation des-Arg-kinins des-Arg-kinins ---> heart function Ca2+ --+> NO Ca2+ --+> arachidonic acid protein kinase C (PKC) signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway G protein mediated signaling pathway via Galphaq family --+> DAG G protein mediated signaling pathway via Galphaq family --+> IP3 IP3 Ca2+ calcium/calcium-mediated signaling pathway G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphai family BK Arrb2 ---- Bdkrb2 GRK4 ---> Bdkrb2 GRK4 heart function perception of pain BK ---> kidney function IP3 --+> Ca2+ DAG --+> protein kinase C (PKC) signaling pathway Arrb1 ---- Bdkrb2 Arrb1 Arrb2 Bdkrb2 ---- KD Bdkrb1 ---- des-Arg-kinins Bdkrb2 ---- BK kidney function Bdkrb1 Bdkrb2 KD ---> perception of pain Ca2+ --+> protein kinase C (PKC) signaling pathway KD DAG arachidonic acid NO calcium transport pathway protein kinase C (PKC) signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway kallikrein-kinin cascade pathway G protein independent events