| URN | urn:agi-llid:7364 |
|---|---|
| Connectivity | 49 |
| Name | UGT2B7 |
| Description | UDP glucuronosyltransferase 2 family, polypeptide B7 |
| Notes | The UGTs (EC 2.4.1.17) serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Its subcellular location is the microsome.[supplied by OMIM] |
| Pathway | losartan pharmacokinetics pathway |
|---|
| GO Molecular Function | glucuronosyltransferase activity |
|---|
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| membrane fraction | |
| microsome | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| lipid metabolic process |
| Ariadne Ontology | Glucose metabolism |
|---|---|
| Steroid metabolism | |
| Heme oxidation |
| Group | Glucose metabolism |
|---|---|
| Steroid metabolism | |
| Heme oxidation | |
| metabolic process | |
| lipid metabolic process | |
| glucuronosyltransferase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| membrane fraction | |
| microsome | |
| integral to membrane |
| MedScan ID | 7364 |
|---|
| Hugo ID | 12554 |
|---|
| Human chromosome position | 4q13 |
|---|
| LocusLink ID | 7364 |
|---|---|
| 286989 |
| Alias | UGT2B9 |
|---|---|
| UDPGTH2 | |
| UDPGT2B7 | |
| UDPGT 2B9 | |
| UDP-glucuronosyltransferase 2B7 | |
| UDPGTh-2 | |
| UDPGT 2B7 | |
| 3,4-catechol estrogen specific | |
| UDP glucuronosyltransferase 2B7 | |
| UDP-glucuronosyltransferase 2B9 | |
| 3,4-catechol estrogen-specific UDPGT | |
| UDP-glucuronyltransferase, family 2, beta-7 | |
| Ugt2b8 | |
| UDPGT 2B8 | |
| UGT2B-RH4 | |
| UDP-glucuronosyltransferase 2B8 | |
| UGTB2B9 | |
| 2(B1) | |
| 3,4-catechol oestrogen specific | |
| liver udp-glucuronosyltransferase | |
| LOC286989 | |
| LOC289537 | |
| MGC93327 | |
| udp glucuronosyltransferase 2 family, polypeptide b1 | |
| udp glucuronosyltransferase 2 family, polypeptide b36 | |
| UDP glucuronosyltransferase 2 family, polypeptide B7 | |
| UDP glycosyltransferase 2 family, polypeptide B7 | |
| UDP-glucuronosyltransferase 2B7 precursor, microsomal | |
| UDP-glucuronyltransferase, family 2, beta VII | |
| UDPGTH II | |
| ugt2b1 | |
| ugt2b36 | |
| UGT2B7 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| OMIM ID | 600068 |
|---|
| GO ID | 0015020 |
|---|---|
| 0006629 | |
| 0008152 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0005792 |
| Rat chromosome position | 14p21 |
|---|
| Swiss-Prot Accession | P16662 |
|---|---|
| Q5QKR3 | |
| Q99912 | |
| Q9HCT7 | |
| Q62789 | |
| B2R810 | |
| Q6GTW0 |
| PIR ID | A35366 |
|---|
| Unigene ID | Hs.654424 |
|---|---|
| Rn.11131 |
| KEGG ID | hsa:7364 |
|---|---|
| rno:286989 |
| EC Number | 2.4.1.17 |
|---|
| Swiss-Prot ID | UD2B7_HUMAN |
|---|---|
| UD2B8_RAT | |
| Q3UEP4_MOUSE | |
| Q68G19_RAT |
| Cell Localization | Microsome membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Cytoplasm | |
| Mitochondria |
| IPI ID | IPI00029784 |
|---|---|
| IPI00208281 | |
| IPI00127223 | |
| IPI00203473 | |
| IPI00471524 |
| Homologene ID | 117350 |
|---|
| RGD ID | 1351542 |
|---|