Ariadne Genomics Inc. Diabetic Nephropathies urate excretion Stroke angiotensin II signaling pathway via AT1 receptor ---| Hypertension angiotensin II signaling pathway via AT1 receptor ---| Heart Failure losartan pharmacodynamics pathway ---| Stroke losartan pharmacodynamics pathway ---| Diabetic Nephropathies losartan ---> losartan pharmacokinetics pathway losartan ---> losartan pharmacodynamics pathway losartan pharmacodynamics pathway --+> urate excretion losartan pharmacodynamics pathway ---| angiotensin II signaling pathway via AT1 receptor Heart Failure Hypertension angiotensin II signaling pathway via AT1 receptor losartan pharmacokinetics pathway losartan losartan pharmacodynamics pathway losartan pleiotropic effects