Elsevier Inc. doxorubicin response pathway doxorubicin adverse effects, cardiotoxicity intrinsic apoptotic pathway p53 signaling pathway DNA damage ---| Neoplasms DNA damage --+> p53 signaling pathway p53 signaling pathway --+> intrinsic apoptotic pathway doxorubicin pharmacodynamics pathway --+> DNA damage doxorubicin --+> doxorubicin response pathway doxorubicin ---> doxorubicin pharmacodynamics pathway doxorubicin ---> doxorubicin pharmacokinetics pathway damage responses, inhibition of DNA replication, transcription Heart Failure Cardiomyopathies Neoplasms doxorubicin DNA damage doxorubicin pharmacodynamics pathway doxorubicin pharmacokinetics pathway