| URN | urn:agi-llid:2247 |
|---|---|
| Connectivity | 1945 |
| Name | Fgf2 |
| Description | fibroblast growth factor 2 (basic) |
| Notes | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| FGFR3 -> STAT signaling | |
| FGFR1 -> STAT signaling | |
| FGFR -> RUNX2 signaling | |
| cerium oxide nanoparticle response pathway |
| GO Molecular Function | growth factor activity |
|---|---|
| fibroblast growth factor receptor binding | |
| nerve growth factor receptor binding | |
| heparin binding | |
| voltage-gated calcium channel activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| cytoplasm | |
| nucleus |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| multicellular organismal development | |
| embryonic development | |
| positive regulation of cardiac muscle cell proliferation | |
| positive regulation of angiogenesis | |
| positive regulation of cell differentiation | |
| induction of an organ | |
| organ morphogenesis | |
| cell differentiation | |
| angiogenesis | |
| nervous system development | |
| lung development | |
| positive regulation of granule cell precursor proliferation | |
| positive regulation of cell fate specification | |
| chondroblast differentiation | |
| adrenocorticotropin hormone secreting cell differentiation | |
| glial cell differentiation | |
| thyroid stimulating hormone secreting cell differentiation | |
| regulation of retinal cell programmed cell death | |
| mammary gland epithelial cell differentiation | |
| branching involved in ureteric bud morphogenesis | |
| negative regulation of cell death | |
| regulation of cell cycle | |
| signal transduction | |
| negative regulation of cell growth | |
| positive regulation of cell division | |
| synaptic transmission | |
| positive regulation of ERK1 and ERK2 cascade | |
| activation of MAPK activity | |
| intracellular protein kinase cascade | |
| Ras protein signal transduction | |
| negative regulation of transcription, DNA-dependent | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| regulation of transcription, DNA-dependent | |
| activation of MAPKK activity | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of blood vessel endothelial cell migration | |
| negative regulation of blood vessel endothelial cell migration | |
| regulation of calcium ion-dependent exocytosis | |
| cell migration involved in sprouting angiogenesis | |
| C21-steroid hormone biosynthetic process | |
| apoptosis | |
| chemotaxis | |
| wound healing | |
| positive regulation of gene expression | |
| nuclear translocation of MAPK | |
| fibroblast growth factor receptor signaling pathway |
| Ariadne Ontology | GF |
|---|
| Group | GF |
|---|---|
| extracellular region | |
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| multicellular organismal development | |
| embryonic development | |
| positive regulation of cardiac muscle cell proliferation | |
| positive regulation of angiogenesis | |
| positive regulation of cell differentiation | |
| induction of an organ | |
| organ morphogenesis | |
| cell differentiation | |
| angiogenesis | |
| nervous system development | |
| lung development | |
| positive regulation of granule cell precursor proliferation | |
| positive regulation of cell fate specification | |
| chondroblast differentiation | |
| adrenocorticotropin hormone secreting cell differentiation | |
| glial cell differentiation | |
| thyroid stimulating hormone secreting cell differentiation | |
| regulation of retinal cell programmed cell death | |
| mammary gland epithelial cell differentiation | |
| branching involved in ureteric bud morphogenesis | |
| negative regulation of cell death | |
| regulation of cell cycle | |
| signal transduction | |
| negative regulation of cell growth | |
| positive regulation of cell division | |
| synaptic transmission | |
| positive regulation of ERK1 and ERK2 cascade | |
| activation of MAPK activity | |
| intracellular protein kinase cascade | |
| Ras protein signal transduction | |
| negative regulation of transcription, DNA-dependent | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| regulation of transcription, DNA-dependent | |
| activation of MAPKK activity | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of blood vessel endothelial cell migration | |
| negative regulation of blood vessel endothelial cell migration | |
| regulation of calcium ion-dependent exocytosis | |
| cell migration involved in sprouting angiogenesis | |
| C21-steroid hormone biosynthetic process | |
| apoptosis | |
| chemotaxis | |
| wound healing | |
| positive regulation of gene expression | |
| nuclear translocation of MAPK | |
| fibroblast growth factor receptor signaling pathway | |
| growth factor activity | |
| fibroblast growth factor receptor binding | |
| nerve growth factor receptor binding | |
| heparin binding | |
| voltage-gated calcium channel activity | |
| extracellular space | |
| cytoplasm | |
| nucleus |
| MedScan ID | 2247 |
|---|
| Hugo ID | 3676 |
|---|
| Human chromosome position | 4q26-q27 |
|---|
| LocusLink ID | 2247 |
|---|---|
| 14173 | |
| 54250 |
| Alias | BFGF |
|---|---|
| FGFB | |
| HBGF-2 | |
| heparin-binding growth factor 2 | |
| prostatropin | |
| basic fibroblast growth factor bFGF | |
| Fgf-2 | |
| DN-452A22.6 | |
| OTTMUSP00000046776 | |
| basic fibroblast growth factor | |
| b-FGF | |
| Fgf2 | |
| FGF2_HUMAN | |
| fibroblast growth factor 2 | |
| fibroblast growth factor 2 (basic) | |
| fibroblast growth factor II | |
| HBGF II | |
| HBGF IIs | |
| HBGH II | |
| HBGH IIs | |
| HBGH-2 | |
| heparin-binding growth factor 2 precusor | |
| heparin-binding growth factor II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 134920 |
|---|
| Mouse chromosome position | 3 19.3 cM |
|---|
| GO ID | 0005104 |
|---|---|
| 0008083 | |
| 0008201 | |
| 0005245 | |
| 0006700 | |
| 0007265 | |
| 0000187 | |
| 0000186 | |
| 0006915 | |
| 0001658 | |
| 0002042 | |
| 0006935 | |
| 0060591 | |
| 0009790 | |
| 0008543 | |
| 0010001 | |
| 0001759 | |
| 0007243 | |
| 0030324 | |
| 0060644 | |
| 0043537 | |
| 0060548 | |
| 0030308 | |
| 0008285 | |
| 0045892 | |
| 0007399 | |
| 0000189 | |
| 0009887 | |
| 0070374 | |
| 0045766 | |
| 0043536 | |
| 0060045 | |
| 0051781 | |
| 0042660 | |
| 0008284 | |
| 0050679 | |
| 0021940 | |
| 0001934 | |
| 0045941 | |
| 0045944 | |
| 0017158 | |
| 0046668 | |
| 0007165 | |
| 0007268 | |
| 0042060 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005634 | |
| 0060128 | |
| 0001525 | |
| 0030154 | |
| 0007275 | |
| 0045597 | |
| 0010628 | |
| 0010552 | |
| 0051726 | |
| 0006355 | |
| 0060129 | |
| 0005163 |
| Rat chromosome position | 2q25 |
|---|
| Swiss-Prot Accession | P09038 |
|---|---|
| P15655 | |
| Q541T2 | |
| Q5SUD8 | |
| Q7TPG9 | |
| Q7TPH0 | |
| Q925A1 | |
| Q925A2 | |
| Q925A3 | |
| P13109 | |
| A0A2U1 | |
| A4LBB8 | |
| O00527 | |
| P78443 | |
| Q16443 | |
| Q5PY50 | |
| Q7KZ11 | |
| Q7KZ72 | |
| Q9UC54 | |
| Q9UCS5 | |
| Q9UCS6 |
| PIR ID | A32398 |
|---|---|
| C37360 | |
| A31674 |
| Unigene ID | Hs.284244 |
|---|---|
| Mm.473689 | |
| Rn.31808 |
| KEGG ID | hsa:2247 |
|---|---|
| mmu:14173 | |
| rno:54250 |
| Swiss-Prot ID | FGF2_HUMAN |
|---|---|
| FGF2_MOUSE | |
| FGF2_RAT | |
| Q541T2_MOUSE |
| Cell Localization | Extracellular |
|---|
| IPI ID | IPI00154603 |
|---|---|
| IPI00930195 | |
| IPI00930557 | |
| IPI00946154 | |
| IPI00132609 | |
| IPI00198326 | |
| IPI00853849 | |
| IPI00649379 | |
| IPI00650065 | |
| IPI00459697 | |
| IPI00647965 | |
| IPI00649899 | |
| IPI00566557 |
| Homologene ID | 1521 |
|---|
| RGD ID | 2609 |
|---|
| MGI ID | 95516 |
|---|