Ariadne Genomics Inc. cerium oxide ---| cancer cells cancer cells NC differentially expressed genes PC12 cells gene expression cerium oxide ---- Fgf2 cerium oxide ---- heparin heparin BaF32 cells cell proliferation Fgf2 ---- Fgfr1 Fgfr1 Fgf2 cerium oxide cerium oxide --+> cell proliferation cerium oxide ---> NC differentially expressed genes cerium oxide ---> ROS modulation Ce(IV) oxide ---> hydrogen peroxide Ce(III) oxide ---> superoxide radical Ce(III) oxide Ce(IV) oxide hydrogen peroxide Diabetes Mellitus Macular Degeneration superoxide radical ROS generation senescence ROS modulation cerium oxide ---| Diabetes Mellitus cerium oxide ---| senescence cytotoxicity dopamine biosynthetic pathway ROS catabolism cerium oxide ---| Macular Degeneration cerium oxide --+> ROS catabolism cerium oxide --+> dopamine biosynthetic pathway cerium oxide ---> cytotoxicity cerium oxide ---| ROS generation cerium oxide ---> gene expression