| URN | urn:agi-llid:581 |
|---|---|
| Connectivity | 1119 |
| Name | Bax |
| Description | BCL2-associated X protein |
| Notes | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. |
| Pathway | Apoptosis |
|---|---|
| intrinsic apoptotic pathway | |
| titanium dioxide nanoparticle response pathway |
| GO Molecular Function | lipid binding |
|---|---|
| chaperone binding | |
| heat shock protein binding | |
| protein homodimerization activity | |
| BH domain binding | |
| protein heterodimerization activity | |
| BH3 domain binding |
| GO Cellular Component | membrane |
|---|---|
| intracellular | |
| soluble fraction | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| cytosol | |
| endoplasmic reticulum | |
| cytosolic part | |
| mitochondrion | |
| mitochondrial outer membrane | |
| mitochondrial membrane | |
| mitochondrial permeability transition pore complex | |
| integral to membrane |
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of anti-apoptosis | |
| negative regulation of cell proliferation | |
| Sertoli cell proliferation | |
| post-embryonic development | |
| leukocyte homeostasis | |
| regulation of nitrogen utilization | |
| fertilization | |
| positive regulation of developmental pigmentation | |
| positive regulation of apoptosis involved in mammary gland involution | |
| cerebral cortex development | |
| retina development in camera-type eye | |
| hypothalamus development | |
| regulation of mammary gland epithelial cell proliferation | |
| germ cell programmed cell death | |
| sex differentiation | |
| spermatid differentiation | |
| germ cell development | |
| development of secondary sexual characteristics | |
| vagina development | |
| male gonad development | |
| nervous system development | |
| kidney development | |
| retinal cell programmed cell death | |
| mitochondrial fusion | |
| mitochondrial fragmentation involved in apoptosis | |
| induction of retinal programmed cell death | |
| limb morphogenesis | |
| post-embryonic camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| blood vessel remodeling | |
| spermatogenesis | |
| regulation of cell cycle | |
| positive regulation of calcium ion transport into cytosol | |
| negative regulation of peptidyl-serine phosphorylation | |
| negative regulation of fibroblast proliferation | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| positive regulation of neuron apoptosis | |
| negative regulation of survival gene product expression | |
| induction of apoptosis in response to chemical stimulus | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis by intracellular signals | |
| positive regulation of B cell apoptosis | |
| negative regulation of neuron apoptosis | |
| regulation of apoptosis | |
| regulation of caspase activity | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| B cell homeostatic proliferation | |
| T cell homeostatic proliferation | |
| inner mitochondrial membrane organization | |
| outer mitochondrial membrane organization | |
| regulation of mitochondrial membrane permeability | |
| nuclear fragmentation involved in apoptotic nuclear change | |
| protein insertion into mitochondrial membrane involved in induction of apoptosis | |
| neuron migration | |
| cellular respiration | |
| DNA fragmentation involved in apoptotic nuclear change | |
| glycosphingolipid metabolic process | |
| regulation of mitochondrial membrane potential | |
| reduction of endoplasmic reticulum calcium ion concentration | |
| apoptotic mitochondrial changes | |
| release of matrix enzymes from mitochondria | |
| release of cytochrome c from mitochondria | |
| response to DNA damage stimulus | |
| cellular response to UV | |
| neuron apoptosis | |
| apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| glial cell apoptosis | |
| transformed cell apoptosis | |
| B cell apoptosis | |
| myeloid cell homeostasis | |
| B cell negative selection | |
| B cell homeostasis | |
| response to drug | |
| response to acid | |
| response to toxin | |
| response to wounding | |
| response to copper ion | |
| response to cocaine | |
| response to corticosterone stimulus | |
| response to axon injury | |
| response to salt stress | |
| response to ionizing radiation | |
| response to gamma radiation | |
| protein homooligomerization | |
| cleavage of lamin | |
| establishment or maintenance of transmembrane electrochemical gradient | |
| ovarian follicle development | |
| homeostasis of number of cells | |
| homeostasis of number of cells within a tissue | |
| regulation of protein homodimerization activity | |
| regulation of protein heterodimerization activity |
| Ariadne Ontology | Bid |
|---|---|
| Tumor suppressors |
| Group | Bid |
|---|---|
| Tumor suppressors | |
| cell proliferation | |
| negative regulation of anti-apoptosis | |
| negative regulation of cell proliferation | |
| Sertoli cell proliferation | |
| post-embryonic development | |
| leukocyte homeostasis | |
| regulation of nitrogen utilization | |
| fertilization | |
| positive regulation of developmental pigmentation | |
| positive regulation of apoptosis involved in mammary gland involution | |
| cerebral cortex development | |
| retina development in camera-type eye | |
| hypothalamus development | |
| regulation of mammary gland epithelial cell proliferation | |
| germ cell programmed cell death | |
| sex differentiation | |
| spermatid differentiation | |
| germ cell development | |
| development of secondary sexual characteristics | |
| vagina development | |
| male gonad development | |
| nervous system development | |
| kidney development | |
| retinal cell programmed cell death | |
| mitochondrial fusion | |
| mitochondrial fragmentation involved in apoptosis | |
| induction of retinal programmed cell death | |
| limb morphogenesis | |
| post-embryonic camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| blood vessel remodeling | |
| spermatogenesis | |
| regulation of cell cycle | |
| positive regulation of calcium ion transport into cytosol | |
| negative regulation of peptidyl-serine phosphorylation | |
| negative regulation of fibroblast proliferation | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| positive regulation of neuron apoptosis | |
| negative regulation of survival gene product expression | |
| induction of apoptosis in response to chemical stimulus | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis by intracellular signals | |
| positive regulation of B cell apoptosis | |
| negative regulation of neuron apoptosis | |
| regulation of apoptosis | |
| regulation of caspase activity | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| B cell homeostatic proliferation | |
| T cell homeostatic proliferation | |
| inner mitochondrial membrane organization | |
| outer mitochondrial membrane organization | |
| regulation of mitochondrial membrane permeability | |
| nuclear fragmentation involved in apoptotic nuclear change | |
| protein insertion into mitochondrial membrane involved in induction of apoptosis | |
| neuron migration | |
| cellular respiration | |
| DNA fragmentation involved in apoptotic nuclear change | |
| glycosphingolipid metabolic process | |
| regulation of mitochondrial membrane potential | |
| reduction of endoplasmic reticulum calcium ion concentration | |
| apoptotic mitochondrial changes | |
| release of matrix enzymes from mitochondria | |
| release of cytochrome c from mitochondria | |
| response to DNA damage stimulus | |
| cellular response to UV | |
| neuron apoptosis | |
| apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| glial cell apoptosis | |
| transformed cell apoptosis | |
| B cell apoptosis | |
| myeloid cell homeostasis | |
| B cell negative selection | |
| B cell homeostasis | |
| response to drug | |
| response to acid | |
| response to toxin | |
| response to wounding | |
| response to copper ion | |
| response to cocaine | |
| response to corticosterone stimulus | |
| response to axon injury | |
| response to salt stress | |
| response to ionizing radiation | |
| response to gamma radiation | |
| protein homooligomerization | |
| cleavage of lamin | |
| establishment or maintenance of transmembrane electrochemical gradient | |
| ovarian follicle development | |
| homeostasis of number of cells | |
| homeostasis of number of cells within a tissue | |
| regulation of protein homodimerization activity | |
| regulation of protein heterodimerization activity | |
| lipid binding | |
| chaperone binding | |
| heat shock protein binding | |
| protein homodimerization activity | |
| BH domain binding | |
| protein heterodimerization activity | |
| BH3 domain binding | |
| membrane | |
| intracellular | |
| soluble fraction | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| cytosol | |
| endoplasmic reticulum | |
| cytosolic part | |
| mitochondrion | |
| mitochondrial outer membrane | |
| mitochondrial membrane | |
| mitochondrial permeability transition pore complex | |
| integral to membrane |
| MedScan ID | 581 |
|---|
| Hugo ID | 959 |
|---|
| Human chromosome position | 19q13.3-q13.4 |
|---|
| LocusLink ID | 581 |
|---|---|
| 12028 | |
| 24887 |
| Alias | BCL2L4 |
|---|---|
| apoptosis regulator BAX | |
| bcl2-L-4 | |
| bcl-2-like protein 4 | |
| Bax | |
| BAX protein | |
| BAX protein, cytoplasmic isoform gamma | |
| bax zeta | |
| BAXB | |
| Bcl2-associated X protein | |
| DXS1283E | |
| rBax alpha |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600040 |
|---|
| Mouse chromosome position | 7 23.0 cM |
|---|
| GO ID | 0051434 |
|---|---|
| 0008289 | |
| 0046982 | |
| 0042803 | |
| 0001783 | |
| 0006309 | |
| 0006919 | |
| 0008635 | |
| 0008637 | |
| 0006922 | |
| 0010248 | |
| 0006917 | |
| 0008624 | |
| 0008629 | |
| 0046674 | |
| 0043653 | |
| 0008053 | |
| 0008634 | |
| 0030264 | |
| 0043525 | |
| 0051260 | |
| 0042981 | |
| 0051881 | |
| 0043497 | |
| 0043496 | |
| 0001836 | |
| 0032976 | |
| 0009636 | |
| 0006927 | |
| 0005737 | |
| 0005829 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005741 | |
| 0005757 | |
| 0005739 | |
| 0051400 | |
| 0051087 | |
| 0031072 | |
| 0001782 | |
| 0002358 | |
| 0002352 | |
| 0060011 | |
| 0001777 | |
| 0006915 | |
| 0070059 | |
| 0001974 | |
| 0008283 | |
| 0045333 | |
| 0034644 | |
| 0021987 | |
| 0045136 | |
| 0009566 | |
| 0007281 | |
| 0035234 | |
| 0006687 | |
| 0048872 | |
| 0048873 | |
| 0021854 | |
| 0031558 | |
| 0007007 | |
| 0001822 | |
| 0001776 | |
| 0035108 | |
| 0008584 | |
| 0002262 | |
| 0019987 | |
| 0008285 | |
| 0048147 | |
| 0043524 | |
| 0033137 | |
| 0007399 | |
| 0051402 | |
| 0001764 | |
| 0042475 | |
| 0007008 | |
| 0001541 | |
| 0002904 | |
| 0043065 | |
| 0060058 | |
| 0010524 | |
| 0048087 | |
| 0051281 | |
| 0048597 | |
| 0009791 | |
| 0001844 | |
| 0032471 | |
| 0043281 | |
| 0051726 | |
| 0033599 | |
| 0046902 | |
| 0006808 | |
| 0006974 | |
| 0001101 | |
| 0048678 | |
| 0010332 | |
| 0010212 | |
| 0009651 | |
| 0009611 | |
| 0060041 | |
| 0046666 | |
| 0007548 | |
| 0048515 | |
| 0007283 | |
| 0060068 | |
| 0044445 | |
| 0005622 | |
| 0031966 | |
| 0005625 | |
| 0034349 | |
| 0042220 | |
| 0046688 | |
| 0051412 | |
| 0042493 | |
| 0045786 | |
| 0005515 |
| Rat chromosome position | 1q31.2 |
|---|
| Swiss-Prot Accession | Q07812 |
|---|---|
| O95074 | |
| Q5ZPJ0 | |
| Q5ZPJ1 | |
| Q8WXU1 | |
| Q9UEI8 | |
| Q07813 | |
| Q544Z6 | |
| Q3TXJ7 | |
| Q8K3J2 | |
| Q8VHY7 | |
| Q9R0K9 | |
| Q63690 | |
| Q9JKL3 | |
| Q62995 | |
| Q64383 | |
| A8K4W1 | |
| P55269 | |
| Q07814 | |
| Q07815 | |
| Q8WZ49 | |
| Q9NR76 | |
| Q9NYG7 | |
| Q9UCZ6 | |
| Q9UCZ7 | |
| Q9UQD6 |
| PIR ID | I53295 |
|---|---|
| D47538 | |
| A47538 | |
| B47538 | |
| C47538 | |
| I38921 | |
| JC7255 |
| Unigene ID | Hs.624291 |
|---|---|
| Mm.19904 | |
| Rn.10668 | |
| Hs.631546 |
| KEGG ID | hsa:581 |
|---|---|
| mmu:12028 | |
| rno:24887 |
| Swiss-Prot ID | BAX_RAT |
|---|---|
| BAX_MOUSE | |
| BAX_HUMAN | |
| Q544Z6_MOUSE | |
| Q9NYG7_HUMAN |
| Cell Localization | Mitochondrion outer membrane |
|---|---|
| Cytoplasm | |
| Mitochondrion membrane |
| IPI ID | IPI00211129 |
|---|---|
| IPI00120684 | |
| IPI00071059 | |
| IPI00439209 | |
| IPI00443773 | |
| IPI00444945 | |
| IPI00445503 | |
| IPI00845474 | |
| IPI00885178 | |
| IPI00885203 |
| Homologene ID | 7242 |
|---|
| RGD ID | 2192 |
|---|
| MGI ID | 99702 |
|---|