| URN | urn:agi-llid:7099 |
|---|---|
| Connectivity | 1012 |
| Name | Tlr4 |
| Description | toll-like receptor 4 |
| Notes | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq] |
| Pathway | TLR -> AP-1 signaling |
|---|---|
| TLR4 -> IRF signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| Toll-like receptor signaling pathway | |
| titanium dioxide nanoparticle response pathway |
| GO Molecular Function | lipopolysaccharide binding |
|---|---|
| lipopolysaccharide receptor activity | |
| phosphoinositide 3-kinase binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| plasma membrane | |
| cytoplasm | |
| membrane raft | |
| intrinsic to membrane | |
| lipopolysaccharide receptor complex | |
| perinuclear region of cytoplasm | |
| external side of plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | immune response |
|---|---|
| response to bacterium | |
| defense response to bacterium | |
| detection of fungus | |
| defense response to Gram-negative bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| negative regulation of osteoclast differentiation | |
| production of nitric oxide involved in inflammatory response | |
| interferon-gamma production | |
| positive regulation of interleukin-12 production | |
| negative regulation of interleukin-17 production | |
| positive regulation of interferon-gamma production | |
| negative regulation of interferon-gamma production | |
| negative regulation of tumor necrosis factor production | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-23 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of interleukin-1 production | |
| positive regulation of interleukin-10 production | |
| positive regulation of chemokine production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interferon-alpha production | |
| positive regulation of interferon-beta production | |
| positive regulation of macrophage cytokine production | |
| positive regulation of interleukin-13 biosynthetic process | |
| positive regulation of interleukin-1 biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| positive regulation of tumor necrosis factor biosynthetic process | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of platelet activation | |
| intestinal epithelial structure maintenance | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of stress-activated MAPK cascade | |
| positive regulation of JNK cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| negative regulation of ERK1 and ERK2 cascade | |
| activation of MAPK activity | |
| positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | |
| positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of lymphocyte proliferation | |
| positive regulation of B cell proliferation | |
| positive regulation of apoptosis | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| macrophage activation | |
| mast cell activation | |
| I-kappaB phosphorylation | |
| cellular response to lipopolysaccharide | |
| cellular response to lipoteichoic acid | |
| innate immune response | |
| activation of innate immune response | |
| immunoglobulin mediated immune response | |
| innate immune response-activating signal transduction | |
| toll-like receptor signaling pathway | |
| T-helper 1 type immune response | |
| response to oxidative stress | |
| response to toxin | |
| response to hypoxia | |
| response to ethanol | |
| detection of lipopolysaccharide | |
| response to lipopolysaccharide | |
| response to lipoteichoic acid | |
| response to fatty acid | |
| response to insulin stimulus | |
| response to progesterone stimulus | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| positive regulation of MHC class II biosynthetic process | |
| positive regulation of DNA binding |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| immune response | |
| response to bacterium | |
| defense response to bacterium | |
| detection of fungus | |
| defense response to Gram-negative bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| negative regulation of osteoclast differentiation | |
| production of nitric oxide involved in inflammatory response | |
| interferon-gamma production | |
| positive regulation of interleukin-12 production | |
| negative regulation of interleukin-17 production | |
| positive regulation of interferon-gamma production | |
| negative regulation of interferon-gamma production | |
| negative regulation of tumor necrosis factor production | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-23 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of interleukin-1 production | |
| positive regulation of interleukin-10 production | |
| positive regulation of chemokine production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interferon-alpha production | |
| positive regulation of interferon-beta production | |
| positive regulation of macrophage cytokine production | |
| positive regulation of interleukin-13 biosynthetic process | |
| positive regulation of interleukin-1 biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| positive regulation of tumor necrosis factor biosynthetic process | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| positive regulation of platelet activation | |
| intestinal epithelial structure maintenance | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of stress-activated MAPK cascade | |
| positive regulation of JNK cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| negative regulation of ERK1 and ERK2 cascade | |
| activation of MAPK activity | |
| positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | |
| positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of lymphocyte proliferation | |
| positive regulation of B cell proliferation | |
| positive regulation of apoptosis | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| macrophage activation | |
| mast cell activation | |
| I-kappaB phosphorylation | |
| cellular response to lipopolysaccharide | |
| cellular response to lipoteichoic acid | |
| innate immune response | |
| activation of innate immune response | |
| immunoglobulin mediated immune response | |
| innate immune response-activating signal transduction | |
| toll-like receptor signaling pathway | |
| T-helper 1 type immune response | |
| response to oxidative stress | |
| response to toxin | |
| response to hypoxia | |
| response to ethanol | |
| detection of lipopolysaccharide | |
| response to lipopolysaccharide | |
| response to lipoteichoic acid | |
| response to fatty acid | |
| response to insulin stimulus | |
| response to progesterone stimulus | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| positive regulation of MHC class II biosynthetic process | |
| positive regulation of DNA binding | |
| lipopolysaccharide binding | |
| lipopolysaccharide receptor activity | |
| phosphoinositide 3-kinase binding | |
| receptor activity | |
| transmembrane receptor activity | |
| cell surface | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| membrane raft | |
| intrinsic to membrane | |
| lipopolysaccharide receptor complex | |
| perinuclear region of cytoplasm | |
| external side of plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 7099 |
|---|
| Hugo ID | 11850 |
|---|
| Human chromosome position | 9q32-q33 |
|---|
| LocusLink ID | 7099 |
|---|---|
| 21898 | |
| 29260 |
| Alias | TOLL |
|---|---|
| CD284 | |
| hToll | |
| ARMD10 | |
| toll-like receptor 4 | |
| homolog of Drosophila toll | |
| Lps | |
| Ly87 | |
| Ran/M1 | |
| Rasl2-8 | |
| OTTMUSP00000000296 | |
| lipopolysaccharide response | |
| toll4 | |
| homolog of toll | |
| OTTHUMP00000022807 | |
| Ran/M I | |
| TLR4 | |
| toll-like receptor IV |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603030 |
|---|---|
| 114500 | |
| 152430 | |
| 611488 |
| Mouse chromosome position | 4 33.0 cM |
|---|
| GO ID | 0001530 |
|---|---|
| 0001875 | |
| 0043548 | |
| 0004872 | |
| 0004888 | |
| 0007249 | |
| 0007252 | |
| 0042088 | |
| 0000187 | |
| 0071222 | |
| 0050829 | |
| 0042742 | |
| 0016046 | |
| 0032497 | |
| 0006955 | |
| 0016064 | |
| 0045087 | |
| 0002758 | |
| 0060729 | |
| 0042116 | |
| 0002282 | |
| 0070373 | |
| 0032689 | |
| 0032700 | |
| 0032707 | |
| 0032715 | |
| 0045671 | |
| 0032720 | |
| 0052033 | |
| 0030890 | |
| 0070374 | |
| 0043123 | |
| 0046330 | |
| 0045348 | |
| 0042346 | |
| 0051092 | |
| 0043065 | |
| 0032722 | |
| 0010552 | |
| 0050729 | |
| 0032727 | |
| 0045359 | |
| 0032728 | |
| 0032729 | |
| 0032732 | |
| 0032733 | |
| 0045084 | |
| 0032735 | |
| 0032755 | |
| 0045416 | |
| 0032757 | |
| 0060907 | |
| 0045429 | |
| 0051770 | |
| 0070430 | |
| 0070434 | |
| 0050731 | |
| 0010572 | |
| 0032874 | |
| 0042535 | |
| 0032760 | |
| 0002537 | |
| 0045471 | |
| 0070542 | |
| 0001666 | |
| 0032868 | |
| 0032496 | |
| 0070391 | |
| 0006979 | |
| 0032570 | |
| 0009636 | |
| 0007165 | |
| 0002224 | |
| 0005737 | |
| 0009897 | |
| 0005887 | |
| 0046696 | |
| 0045121 | |
| 0048471 | |
| 0005886 | |
| 0007250 | |
| 0002218 | |
| 0071223 | |
| 0006954 | |
| 0032609 | |
| 0045576 | |
| 0043388 | |
| 0045362 | |
| 0045368 | |
| 0045410 | |
| 0050671 | |
| 0051091 | |
| 0050727 | |
| 0009617 | |
| 0009986 | |
| 0016021 | |
| 0031224 | |
| 0016020 | |
| 0051384 |
| Rat chromosome position | 5q24 |
|---|
| Swiss-Prot Accession | O00206 |
|---|---|
| Q9QUK6 | |
| Q3U4D4 | |
| Q8K2T5 | |
| Q9QX05 | |
| Q9D691 | |
| Q9QZF5 | |
| Q9Z203 | |
| A8K1Y8 | |
| A9XLP9 | |
| A9XLQ0 | |
| A9XLQ1 | |
| B4E194 | |
| Q5VZI8 | |
| Q5VZI9 | |
| Q9UK78 | |
| Q9UM57 | |
| D1CS53 |
| Unigene ID | Hs.174312 |
|---|---|
| Mm.38049 | |
| Rn.14534 |
| KEGG ID | hsa:7099 |
|---|---|
| mmu:21898 | |
| rno:29260 |
| Swiss-Prot ID | TLR4_RAT |
|---|---|
| TLR4_MOUSE | |
| TLR4_HUMAN | |
| D1CS53_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00212570 |
|---|---|
| IPI00131730 | |
| IPI00008673 | |
| IPI00374265 | |
| IPI00914904 | |
| IPI00649472 |
| Homologene ID | 41317 |
|---|
| RGD ID | 3870 |
|---|
| MGI ID | 96824 |
|---|