Protein Casp8

URN	urn:agi-llid:841
Connectivity	793
Name	Casp8
Description	caspase 8, apoptosis-related cysteine peptidase
Notes	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq]

Pathway	TNFRSF6 -> FOXO3A signaling
	Apoptosis
	Trail mediated signaling pathway
	FasL mediated signaling pathway
	titanium dioxide nanoparticle response pathway

GO Molecular Function	hydrolase activity
	peptidase activity
	cysteine-type peptidase activity
	cysteine-type endopeptidase activity

GO Cellular Component	protein complex
	cytoplasm
	membrane raft
	Noc1p-Noc2p complex
	cytosol
	mitochondrion
	mitochondrial outer membrane
	cytoskeleton
	nucleus
	death-inducing signaling complex

GO Biological Process	angiogenesis
	neural tube formation
	heart development
	macrophage differentiation
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	activation of pro-apoptotic gene products
	induction of apoptosis by extracellular signals
	regulation of apoptosis
	apoptosis
	response to antibiotic
	response to cold
	response to ethanol
	response to cobalt ion
	response to lipopolysaccharide
	response to tumor necrosis factor
	response to estradiol stimulus
	protein heterooligomerization
	proteolysis
	proteolysis involved in cellular protein catabolic process

Ariadne Ontology	CASP8-10

Group	CASP8-10
	angiogenesis
	neural tube formation
	heart development
	macrophage differentiation
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	activation of pro-apoptotic gene products
	induction of apoptosis by extracellular signals
	regulation of apoptosis
	apoptosis
	response to antibiotic
	response to cold
	response to ethanol
	response to cobalt ion
	response to lipopolysaccharide
	response to tumor necrosis factor
	response to estradiol stimulus
	protein heterooligomerization
	proteolysis
	proteolysis involved in cellular protein catabolic process
	hydrolase activity
	peptidase activity
	cysteine-type peptidase activity
	cysteine-type endopeptidase activity
	protein complex
	cytoplasm
	membrane raft
	Noc1p-Noc2p complex
	cytosol
	mitochondrion
	mitochondrial outer membrane
	cytoskeleton
	nucleus
	death-inducing signaling complex

MedScan ID	841

Hugo ID	1509

Human chromosome position	2q33-q34

Alias	CAP4
	MACH
	MCH5
	FLICE
	ALPS2B
	Casp-8
	FLJ17672
	MGC78473
	caspase-8
	FADD-like ICE
	OTTHUMP00000163720
	OTTHUMP00000165063
	OTTHUMP00000206557
	OTTHUMP00000206581
	MACH-alpha-1/2/3 protein
	apoptotic protease Mch-5
	MACH-beta-1/2/3/4 protein
	apoptotic cysteine protease
	ICE-like apoptotic protease 5
	MORT1-associated ced-3 homolog
	FADD-homologous ICE/CED-3-like protease
	caspase 8, apoptosis-related cysteine protease
	Fas-linked ICE-like protease
	CASP8
	Apoptotic protease Mch V
	caspase 8
	caspase 8 isoform A
	caspase 8 isoform B
	caspase 8 isoform C
	caspase 8 isoform D
	caspase 8 isoform E
	caspase 8, apoptosis-related cysteine peptidase
	caspase VIII
	FLICE/MACH1
	ICE-like apoptotic protease V
	LOC116239
	Mch5 isoform alpha
	OTTHUMP00000163718
	OTTHUMP00000163719
	Pro- Casp8
	procaspase 8
	procaspase 8L
	procaspase-8
	cysteine protease

Mouse chromosome position	1 30.1 cM

Rat chromosome position	9q31

EC Number	3.4.22.61

Cell Localization	Cytoplasm

Homologene ID	7657

RGD ID	620945

MGI ID	1261423