| URN | urn:agi-llid:355 |
|---|---|
| Connectivity | 1537 |
| Name | Fas |
| Description | Fas (TNF receptor superfamily, member 6) |
| Notes | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq] |
| Pathway | TNFR -> AP-1/ATF/TP53 signaling |
|---|---|
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| TNFRSF6 -> FOXO3A signaling | |
| TNFRSF6 -> HSF1 signaling | |
| FasL mediated signaling pathway | |
| titanium dioxide nanoparticle response pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| kinase binding | |
| tumor necrosis factor receptor activity | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| membrane raft | |
| perinuclear region of cytoplasm | |
| cytosol | |
| external side of plasma membrane | |
| death-inducing signaling complex | |
| caveola | |
| integral to membrane |
| GO Biological Process | regulation of cell proliferation |
|---|---|
| aging | |
| immune response | |
| ovulation cycle | |
| spleen development | |
| dendrite regeneration | |
| regulation of myeloid cell differentiation | |
| regulation of lymphocyte differentiation | |
| renal system process | |
| spermatogenesis | |
| signal transduction | |
| positive regulation of necrotic cell death | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| activation of pro-apoptotic gene products | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis via death domain receptors | |
| negative regulation of B cell activation | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| regulation of apoptosis | |
| apoptosis | |
| inflammatory cell apoptosis | |
| transformed cell apoptosis | |
| activation-induced cell death of T cells | |
| T cell homeostasis | |
| immunoglobulin production | |
| B cell mediated immunity | |
| negative thymic T cell selection | |
| response to drug | |
| response to inorganic substance | |
| response to toxin | |
| response to hypoxia | |
| response to protein stimulus | |
| response to growth factor stimulus | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| protein complex assembly | |
| protein homooligomerization | |
| gene expression |
| Ariadne Ontology | TNFR |
|---|
| Group | TNFR |
|---|---|
| extracellular region | |
| regulation of cell proliferation | |
| aging | |
| immune response | |
| ovulation cycle | |
| spleen development | |
| dendrite regeneration | |
| regulation of myeloid cell differentiation | |
| regulation of lymphocyte differentiation | |
| renal system process | |
| spermatogenesis | |
| signal transduction | |
| positive regulation of necrotic cell death | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| activation of pro-apoptotic gene products | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis via death domain receptors | |
| negative regulation of B cell activation | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| regulation of apoptosis | |
| apoptosis | |
| inflammatory cell apoptosis | |
| transformed cell apoptosis | |
| activation-induced cell death of T cells | |
| T cell homeostasis | |
| immunoglobulin production | |
| B cell mediated immunity | |
| negative thymic T cell selection | |
| response to drug | |
| response to inorganic substance | |
| response to toxin | |
| response to hypoxia | |
| response to protein stimulus | |
| response to growth factor stimulus | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| protein complex assembly | |
| protein homooligomerization | |
| gene expression | |
| signal transducer activity | |
| kinase binding | |
| tumor necrosis factor receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| cell surface | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| membrane raft | |
| perinuclear region of cytoplasm | |
| cytosol | |
| external side of plasma membrane | |
| death-inducing signaling complex | |
| caveola | |
| integral to membrane |
| MedScan ID | 355 |
|---|
| Hugo ID | 11920 |
|---|
| Human chromosome position | 10q24.1 |
|---|
| LocusLink ID | 355 |
|---|---|
| 14102 | |
| 246097 |
| Alias | APT1 |
|---|---|
| CD95 | |
| FAS1 | |
| APO-1 | |
| FASTM | |
| ALPS1A | |
| TNFRSF6 | |
| RP11-399O19.7 | |
| tumor necrosis factor receptor superfamily member 6 | |
| Fas AMA | |
| Fas antigen | |
| CD95 antigen | |
| apo-1 antigen | |
| FASLG receptor | |
| OTTHUMP00000217569 | |
| apoptosis antigen 1 | |
| APO-1 cell surface antigen | |
| apoptosis-mediating surface antigen FAS | |
| tumor necrosis factor receptor superfamily, member 6 | |
| lpr | |
| APO1 | |
| TNFR6 | |
| AI196731 | |
| lymphoproliferation | |
| Fas (TNF receptor superfamily member) | |
| Fas receptor | |
| Fas antigen (ATP1) | |
| APO I | |
| APO-1/FAS | |
| apoptosis (APO-1) antigen 1 | |
| apoptosis (APO-1) antigen I | |
| apoptosis antigen I | |
| APT I | |
| fas | |
| Fas (TNF receptor superfamily member 6) | |
| FAS I | |
| Fas receptors | |
| FASL receptor | |
| FASL receptors | |
| FasR | |
| LOC365454 | |
| LOC368136 | |
| lymphoproliferation gene | |
| lymphoproliferation protein | |
| OTTHUMP00000020045 | |
| OTTHUMP00000020046 | |
| OTTHUMP00000020051 | |
| OTTHUMP00000059646 | |
| sFas | |
| TNR6 | |
| TNR6_HUMAN | |
| tumor necrosis factor receptor 6 | |
| tumour necrosis factor receptor 6 | |
| tumour necrosis factor receptor superfamily member 6 | |
| Tumor necrosis factor receptor superfamily member 6 precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 134637 |
|---|---|
| 601859 |
| Mouse chromosome position | 19 23.0 cM |
|---|
| GO ID | 0019900 |
|---|---|
| 0004872 | |
| 0004871 | |
| 0004888 | |
| 0008633 | |
| 0006916 | |
| 0006915 | |
| 0006955 | |
| 0006917 | |
| 0008624 | |
| 0010940 | |
| 0006461 | |
| 0042981 | |
| 0007165 | |
| 0005829 | |
| 0031264 | |
| 0005576 | |
| 0016021 | |
| 0005886 | |
| 0005625 | |
| 0005031 | |
| 0019724 | |
| 0043029 | |
| 0006924 | |
| 0031104 | |
| 0010467 | |
| 0002377 | |
| 0008625 | |
| 0006925 | |
| 0050869 | |
| 0043066 | |
| 0045060 | |
| 0043065 | |
| 0051260 | |
| 0042127 | |
| 0045619 | |
| 0045637 | |
| 0003014 | |
| 0051384 | |
| 0051789 | |
| 0009636 | |
| 0048536 | |
| 0006927 | |
| 0009986 | |
| 0009897 | |
| 0016020 | |
| 0045121 | |
| 0048471 | |
| 0007568 | |
| 0042698 | |
| 0034097 | |
| 0042493 | |
| 0043627 | |
| 0070848 | |
| 0001666 | |
| 0010035 | |
| 0032496 | |
| 0043434 | |
| 0007283 | |
| 0005901 | |
| 0042802 | |
| 0005515 |
| Rat chromosome position | 1q52 |
|---|
| Swiss-Prot Accession | P25445 |
|---|---|
| Q5T9P3 | |
| Q59FU8 | |
| Q6ICT6 | |
| Q8IUB6 | |
| Q8IUB7 | |
| Q9UEL0 | |
| Q9UET8 | |
| Q8C350 | |
| P25446 | |
| Q6GT31 | |
| Q63199 | |
| Q9R230 | |
| Q9DCQ1 | |
| A9UJX4 | |
| B6VNV4 | |
| Q14292 | |
| Q14293 | |
| Q14294 | |
| Q14295 | |
| Q16652 | |
| Q5T9P1 | |
| Q5T9P2 | |
| Q6SSE9 |
| PIR ID | JC2395 |
|---|---|
| A46484 | |
| A40036 | |
| I37383 | |
| I37384 | |
| S58662 |
| Unigene ID | Hs.244139 |
|---|---|
| Mm.1626 | |
| Rn.162521 |
| KEGG ID | hsa:355 |
|---|---|
| mmu:14102 | |
| rno:246097 |
| Swiss-Prot ID | TNR6_RAT |
|---|---|
| TNR6_MOUSE | |
| TNR6_HUMAN | |
| Q8C350_MOUSE | |
| Q6GT31_MOUSE | |
| Q5T9P3_HUMAN | |
| Q5T9P1_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00206056 |
|---|---|
| IPI00110896 | |
| IPI00170811 | |
| IPI00216357 | |
| IPI00216358 | |
| IPI00216359 | |
| IPI00291314 | |
| IPI00744894 | |
| IPI00929822 | |
| IPI00929902 | |
| IPI00375340 | |
| IPI00235003 | |
| IPI00748193 | |
| IPI00874636 | |
| IPI00560281 | |
| IPI00781030 |
| Homologene ID | 27 |
|---|
| RGD ID | 619831 |
|---|
| MGI ID | 95484 |
|---|