Protein Kat5

URN	urn:agi-llid:10524
Total Entities	0
Connectivity	388
Name	Kat5
Description	K(lysine) acetyltransferase 5
Notes	The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Ariadne Ontology	Chromatin remodeling

GO Molecular Function	protein complex binding
	transcription factor binding
	repressing transcription factor binding
	androgen receptor binding
	metal ion binding
	transferase activity
	transferase activity, transferring acyl groups
	transferase activity, transferring acyl groups other than amino-acyl groups
	histone acetyltransferase activity
	transcription coactivator activity

GO Cellular Component	nucleolus
	NuA4 histone acetyltransferase complex
	Piccolo NuA4 histone acetyltransferase complex
	transcription factor complex
	histone acetyltransferase complex
	chromatin
	protein complex
	cytoplasm
	perinuclear region of cytoplasm
	cytosol
	nucleus

GO Biological Process	virus-host interaction
	androgen receptor signaling pathway
	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription, DNA-dependent
	double-strand break repair
	histone acetylation
	histone H4 acetylation
	chromatin modification
	negative regulation of interleukin-2 production
	regulation of growth

Pathway	TRRAP/TIP60 Chromatin Remodeling
	Histone Acetylation
	ataxia telangiectasia-mutated (ATM) signaling pathway

Group	Chromatin remodeling
	virus-host interaction
	androgen receptor signaling pathway
	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription, DNA-dependent
	double-strand break repair
	histone acetylation
	histone H4 acetylation
	chromatin modification
	negative regulation of interleukin-2 production
	regulation of growth
	protein complex binding
	transcription factor binding
	repressing transcription factor binding
	androgen receptor binding
	metal ion binding
	transferase activity
	transferase activity, transferring acyl groups
	transferase activity, transferring acyl groups other than amino-acyl groups
	histone acetyltransferase activity
	transcription coactivator activity
	nucleolus
	NuA4 histone acetyltransferase complex
	Piccolo NuA4 histone acetyltransferase complex
	transcription factor complex
	histone acetyltransferase complex
	chromatin
	protein complex
	cytoplasm
	perinuclear region of cytoplasm
	cytosol
	nucleus

MedScan ID	10524

Hugo ID	5275

Human chromosome position	11q13

Alias	TIP
	ESA1
	PLIP
	TIP60
	cPLA2
	HTATIP
	HTATIP1
	histone acetyltransferase KAT5
	K-acetyltransferase 5
	cPLA2 interacting protein
	lysine acetyltransferase 5
	cPLA(2)-interacting protein
	60 kDa Tat-interactive protein
	Tat interacting protein, 60kDa
	histone acetyltransferase HTATIP
	HIV-1 Tat interactive protein, 60kDa
	Tip55
	AI839539
	Tat-interactive protein-60
	HIV-1 tat interactive protein 1, homolog
	HIV-1 tat interactive protein 1, 60 kDa homolog
	HIV-1 Tat interactive protein 60 kD
	HIV-1 Tat interactive protein, 60 kD
	HIV-1 tat interactive protein, homolog
	Tip60b
	Tat interactive protein (60kD)
	K(lysine) acetyltransferase 5
	60 kDa Tat interactive protein
	LOC225859
	MGC117972
	MGC95167
	mHTATIP/CPLA2
	HTATIP I
	tat interactive protein
	cPLA2 interactive protein
	GNB:1381394
	hiv-1 tat interactive protein 1, 60 kda homolog (human)
	hiv-1 tat interactive protein 1, homolog (human)
	HIV-1 Tat interactive protein, 60 kDa
	HIV-1 Tat interactive protein

OMIM ID	601409

EC Number	2.3.1.48

Mouse chromosome position	19

Rat chromosome position	1q43

Homologene ID	100661

MGI ID	1932051

RGD ID	621061

Primary Cell Localization	Nucleus