| URN | urn:agi-llid:3014 |
|---|---|
| Total Entities | 0 |
| Connectivity | 658 |
| Name | H2afx |
| Description | H2A histone family, member X |
| Notes | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Chromatin remodeling |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | histone binding |
|---|---|
| enzyme binding | |
| protein heterodimerization activity | |
| DNA binding | |
| damaged DNA binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| condensed nuclear chromosome | |
| nuclear chromatin | |
| chromosome, telomeric region | |
| chromatin | |
| nucleosome | |
| replication fork | |
| chromosome | |
| XY body | |
| nucleus | |
| male germ cell nucleus |
| GO Biological Process | cell cycle |
|---|---|
| DNA damage checkpoint | |
| meiosis | |
| positive regulation of DNA repair | |
| DNA repair | |
| DNA recombination | |
| double-strand break repair | |
| double-strand break repair via homologous recombination | |
| response to DNA damage stimulus | |
| nucleosome assembly | |
| response to ionizing radiation | |
| spermatogenesis |
| Pathway | INO80 Chromatin Remodeling |
|---|---|
| TRRAP/TIP60 Chromatin Remodeling | |
| Histone Phosphorylation | |
| Cell Cycle | |
| Double Strand DNA Homologous Repair | |
| Double Strand DNA Non-Homologous Repair | |
| ataxia telangiectasia-mutated (ATM) signaling pathway |
| Group | Chromatin remodeling |
|---|---|
| cell cycle | |
| DNA damage checkpoint | |
| meiosis | |
| positive regulation of DNA repair | |
| DNA repair | |
| DNA recombination | |
| double-strand break repair | |
| double-strand break repair via homologous recombination | |
| response to DNA damage stimulus | |
| nucleosome assembly | |
| response to ionizing radiation | |
| spermatogenesis | |
| histone binding | |
| enzyme binding | |
| protein heterodimerization activity | |
| DNA binding | |
| damaged DNA binding | |
| nucleoplasm | |
| condensed nuclear chromosome | |
| nuclear chromatin | |
| chromosome, telomeric region | |
| chromatin | |
| nucleosome | |
| replication fork | |
| chromosome | |
| XY body | |
| nucleus | |
| male germ cell nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3014 |
|---|
| Hugo ID | 4739 |
|---|
| Human chromosome position | 11q23.3 |
|---|
| LocusLink ID | 3014 |
|---|---|
| 15270 | |
| 500987 |
| Alias | H2AX |
|---|---|
| H2A.X | |
| H2A/X | |
| histone H2A.x | |
| H2AX histone | |
| AW228881 | |
| Hist5-2ax | |
| gammaH2ax | |
| histone 5 protein 2ax | |
| RGD1566119 | |
| H2A histone family, member X | |
| H2afx | |
| histone 2ax | |
| LOC115272 | |
| histone H2ax | |
| histone family H2A, member X | |
| histone 5 2ax | |
| histone 2a.x |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601772 |
|---|
| Unigene ID | Hs.477879 |
|---|---|
| Mm.245931 | |
| Rn.2850 |
| KEGG ID | hsa:3014 |
|---|---|
| mmu:15270 | |
| rno:500987 |
| Swiss-Prot Accession | P16104 |
|---|---|
| P27661 | |
| D3ZXP3 | |
| Q4ZGJ7 | |
| Q6IAS5 |
| GO ID | 0003677 |
|---|---|
| 0003684 | |
| 0019899 | |
| 0042393 | |
| 0046982 | |
| 0000077 | |
| 0006281 | |
| 0006302 | |
| 0000724 | |
| 0007126 | |
| 0006334 | |
| 0045739 | |
| 0006974 | |
| 0010212 | |
| 0007283 | |
| 0001741 | |
| 0000781 | |
| 0000794 | |
| 0001673 | |
| 0000790 | |
| 0005654 | |
| 0000786 | |
| 0005634 | |
| 0005657 | |
| 0006310 | |
| 0007049 | |
| 0000785 | |
| 0005694 |
| PIR ID | I48406 |
|---|---|
| S07631 |
| Swiss-Prot ID | H2AX_MOUSE |
|---|---|
| H2AX_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Chromosome |
| IPI ID | IPI00230264 |
|---|---|
| IPI00219037 |
| Mouse chromosome position | 9 26.0 cM |
|---|
| Rat chromosome position | 8q22 |
|---|
| Homologene ID | 115922 |
|---|
| MGI ID | 102688 |
|---|
| RGD ID | 1566119 |
|---|
| Primary Cell Localization | Nucleus |
|---|