| URN | urn:agi-llid:9025 |
|---|---|
| Total Entities | 0 |
| Connectivity | 162 |
| Name | RNF8 |
| Description | ring finger protein 8, E3 ubiquitin protein ligase |
| Notes | The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| GO Molecular Function | ubiquitin-protein ligase activity |
|---|---|
| chromatin binding | |
| histone binding | |
| ubiquitin protein ligase binding | |
| protein homodimerization activity | |
| zinc ion binding |
| GO Cellular Component | site of double-strand break |
|---|---|
| chromosome, telomeric region | |
| ubiquitin ligase complex | |
| midbody | |
| nucleus |
| GO Biological Process | spermatid development |
|---|---|
| isotype switching | |
| positive regulation of DNA repair | |
| double-strand break repair | |
| interstrand cross-link repair | |
| double-strand break repair via nonhomologous end joining | |
| histone H2A ubiquitination | |
| histone H2B ubiquitination | |
| histone H2A K63-linked ubiquitination | |
| mitosis | |
| cellular response to DNA damage stimulus | |
| response to ionizing radiation | |
| negative regulation of translational elongation | |
| protein autoubiquitination | |
| protein K48-linked ubiquitination | |
| protein K63-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| histone exchange |
| Pathway | ataxia telangiectasia-mutated (ATM) signaling pathway |
|---|---|
| Copy of 'ataxia telangiectasia-mutated (ATM) signaling pathway' |
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| spermatid development | |
| isotype switching | |
| positive regulation of DNA repair | |
| double-strand break repair | |
| interstrand cross-link repair | |
| double-strand break repair via nonhomologous end joining | |
| histone H2A ubiquitination | |
| histone H2B ubiquitination | |
| histone H2A K63-linked ubiquitination | |
| mitosis | |
| cellular response to DNA damage stimulus | |
| response to ionizing radiation | |
| negative regulation of translational elongation | |
| ubiquitin-protein ligase activity | |
| protein autoubiquitination | |
| protein K48-linked ubiquitination | |
| protein K63-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| histone exchange | |
| chromatin binding | |
| histone binding | |
| ubiquitin protein ligase binding | |
| protein homodimerization activity | |
| zinc ion binding | |
| site of double-strand break | |
| chromosome, telomeric region | |
| ubiquitin ligase complex | |
| midbody | |
| nucleus |
| LocusLink ID | 9025 |
|---|---|
| 58230 | |
| 361815 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Midbody | |
| Chromosome | |
| Telomere |
| GO ID | 0003682 |
|---|---|
| 0042393 | |
| 0042803 | |
| 0031625 | |
| 0004842 | |
| 0008270 | |
| 0006974 | |
| 0006302 | |
| 0006303 | |
| 0070535 | |
| 0033522 | |
| 0033523 | |
| 0043486 | |
| 0036297 | |
| 0045190 | |
| 0007067 | |
| 0045900 | |
| 0045739 | |
| 0070936 | |
| 0070534 | |
| 0051865 | |
| 0010212 | |
| 0007286 | |
| 0006511 | |
| 0000781 | |
| 0030496 | |
| 0005634 | |
| 0035861 | |
| 0000151 | |
| 0051301 | |
| 0016881 | |
| 0016874 | |
| 0046872 | |
| 0006281 | |
| 0007049 | |
| 0016568 | |
| 0016567 | |
| 0005694 |
| Alias | hRNF8 |
|---|---|
| E3 ubiquitin-protein ligase RNF8 | |
| C3HC4-type zinc finger protein | |
| ring finger protein (C3HC4 type) 8 | |
| UBC13/UEV-interacting ring finger protein | |
| KIAA0646 | |
| RNF8 | |
| RING finger protein VIII | |
| RING finger protein 8 | |
| RING finger protein (C3HC4 type) VIII | |
| OTTHUMP00000016323 | |
| FLJ12013 | |
| AIP37 | |
| C3HC4-type zinc finger protein 8 | |
| zinc finger protein AIP37 | |
| OTTHUMP00000039684 | |
| 3830404E21Rik | |
| laXp180 | |
| ActA binding protein 2 | |
| actA-interacting protein 37 | |
| MGC116114 | |
| mKIAA0646 | |
| 3830404E21 | |
| LOC445272 |
| Mouse chromosome position | 17 |
|---|
| OMIM ID | 611685 |
|---|
| Rat chromosome position | 20p12 |
|---|
| Hugo ID | 10071 |
|---|
| Human chromosome position | 6p21.3 |
|---|
| Swiss-Prot Accession | O76064 |
|---|---|
| A6NN24 | |
| A8MYC0 | |
| B4DPG0 | |
| Q53H16 | |
| Q5NKW5 | |
| Q8VC56 | |
| Q4KLN8 | |
| Q4FJV7 | |
| Q9JK13 |
| Unigene ID | Hs.485278 |
|---|---|
| Mm.305994 | |
| Rn.12463 |
| KEGG ID | hsa:9025 |
|---|---|
| mmu:58230 | |
| rno:361815 |
| Swiss-Prot ID | RNF8_HUMAN |
|---|---|
| RNF8_MOUSE | |
| RNF8_RAT |
| EC Number | 6.3.2.- |
|---|
| Ensembl ID | ENSG00000112130 |
|---|---|
| ENSP00000362578 | |
| ENST00000373479 |
| Homologene ID | 2944 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1929069 |
|---|
| RGD ID | 1308035 |
|---|
| MedScan ID | 9025 |
|---|---|
| 58230 |
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00551150 |
|---|---|
| IPI00372827 | |
| IPI00022561 | |
| IPI00923427 |