Protein RNF40

URN	urn:agi-llid:9810
Total Entities	0
Connectivity	69
Name	RNF40
Description	ring finger protein 40, E3 ubiquitin protein ligase
Notes	The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GO Molecular Function	ligase activity
	ubiquitin-protein ligase activity
	protein complex binding
	syntaxin-1 binding
	ubiquitin protein ligase binding
	protein homodimerization activity
	metal ion binding
	zinc ion binding

GO Biological Process	histone monoubiquitination
	histone H2B ubiquitination
	ubiquitin-dependent protein catabolic process
	chromatin modification

Pathway	ataxia telangiectasia-mutated (ATM) signaling pathway
	Copy of 'ataxia telangiectasia-mutated (ATM) signaling pathway'

Group	Ubiquitin-dependent protein degradation
	histone monoubiquitination
	histone H2B ubiquitination
	ligase activity
	ubiquitin-protein ligase activity
	ubiquitin-dependent protein catabolic process
	chromatin modification
	protein complex binding
	syntaxin-1 binding
	ubiquitin protein ligase binding
	protein homodimerization activity
	metal ion binding
	zinc ion binding
	nucleolus
	HULC complex
	protein complex
	ubiquitin ligase complex
	plasma membrane
	cytoplasm
	nucleus
	neuron projection

Cell Localization	Cytoplasm
	Nucleus

Alias	BRE1B
	RBP95
	STARING
	E3 ubiquitin-protein ligase BRE1B
	BRE1-B
	Rb-associated protein
	BRE1 E3 ubiquitin ligase homolog B
	95 kDa retinoblastoma-associated protein
	95 kDa retinoblastoma protein binding protein
	AI848422
	mKIAA0661
	protein staring
	staring protein
	syntaxin-1-interacting RING finger protein
	Kiaa0661
	Rb associated protein
	RING finger protein 40
	RNF40
	ring finger protein 40, E3 ubiquitin protein ligase
	DKFZp686k191
	MGC13051
	LOC233900
	likely ortholog of rat staring
	MGC19037

Mouse chromosome position	7

OMIM ID	607700

Rat chromosome position	1q36

Hugo ID	16867

Human chromosome position	16p11.2-p11.1

PIR ID	JC7363

EC Number	6.3.2.-

Homologene ID	8856

MGI ID	2142048

RGD ID	628638

MedScan ID	9810

Primary Cell Localization	Cytoplasm