Protein KAT5

URN	urn:agi-llid:10524
Total Entities	0
Connectivity	549
Name	KAT5
Description	K(lysine) acetyltransferase 5
Notes	The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GO Molecular Function	histone acetyltransferase activity
	transcription coactivator activity
	transferase activity
	transferase activity, transferring acyl groups
	transferase activity, transferring acyl groups other than amino-acyl groups
	protein complex binding
	transcription factor binding
	repressing transcription factor binding
	androgen receptor binding
	metal ion binding

GO Cellular Component	nucleolus
	histone acetyltransferase complex
	NuA4 histone acetyltransferase complex
	Piccolo NuA4 histone acetyltransferase complex
	chromatin
	protein complex
	transcription factor complex
	cytoplasm
	cytosol
	perinuclear region of cytoplasm
	nucleus

GO Biological Process	double-strand break repair
	histone acetylation
	histone H4 acetylation
	negative regulation of interleukin-2 production
	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
	androgen receptor signaling pathway
	response to ionizing radiation
	positive regulation of transcription, DNA-templated
	positive regulation of transcription from RNA polymerase II promoter
	regulation of growth
	negative regulation of transcription, DNA-templated
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-templated
	transcription, DNA-templated
	proteasome-mediated ubiquitin-dependent protein catabolic process
	modulation by virus of host morphology or physiology
	chromatin modification

Pathway	TRRAP/TIP60 Chromatin Remodeling
	Histone Acetylation
	Alzheimer's Disease Overview
	Ca2+ Toxicity in Alzheimer's Disease
	APP Processing
	ataxia telangiectasia-mutated (ATM) signaling pathway
	Copy of 'ataxia telangiectasia-mutated (ATM) signaling pathway'

Group	Chromatin remodeling
	double-strand break repair
	histone acetylation
	histone acetyltransferase activity
	histone H4 acetylation
	negative regulation of interleukin-2 production
	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
	androgen receptor signaling pathway
	response to ionizing radiation
	positive regulation of transcription, DNA-templated
	positive regulation of transcription from RNA polymerase II promoter
	regulation of growth
	negative regulation of transcription, DNA-templated
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-templated
	transcription coactivator activity
	transferase activity
	transferase activity, transferring acyl groups
	transferase activity, transferring acyl groups other than amino-acyl groups
	transcription, DNA-templated
	proteasome-mediated ubiquitin-dependent protein catabolic process
	modulation by virus of host morphology or physiology
	chromatin modification
	protein complex binding
	transcription factor binding
	repressing transcription factor binding
	androgen receptor binding
	metal ion binding
	nucleolus
	histone acetyltransferase complex
	NuA4 histone acetyltransferase complex
	Piccolo NuA4 histone acetyltransferase complex
	chromatin
	protein complex
	transcription factor complex
	cytoplasm
	cytosol
	perinuclear region of cytoplasm
	nucleus

Alias	TIP
	ESA1
	PLIP
	TIP60
	cPLA2
	HTATIP
	ZC2HC5
	HTATIP1
	histone acetyltransferase KAT5
	K-acetyltransferase 5
	cPLA2 interacting protein
	cPLA(2)-interacting protein
	60 kDa Tat-interactive protein
	Tat interacting protein, 60kDa
	histone acetyltransferase HTATIP
	HIV-1 Tat interactive protein, 60kDa
	Tip55
	AI839539
	Tat-interactive protein-60
	lysine acetyltransferase 5
	HIV-1 tat interactive protein 1, homolog
	HIV-1 tat interactive protein 1, 60 kDa homolog
	HIV-1 Tat interactive protein 60 kD
	HIV-1 Tat interactive protein, 60 kD
	HIV-1 tat interactive protein, homolog
	Tip60b
	mHTATIP/CPLA2
	tat interactive protein
	MGC117972
	LOC225859
	MGC95167
	Tat interactive protein (60kD)
	acetyltransferase KAT5
	KAT5/TIP60
	KAT5 gene
	TIP60/KAT5
	60 kDa Tat interactive protein
	cPLA2 interactive protein
	K(lysine) acetyltransferase 5
	GNB:1381394
	HIV-1 Tat interactive protein
	HTATIP I
	hiv-1 tat interactive protein 1, 60 kda homolog (human)
	HIV-1 Tat interactive protein, 60 kDa
	hiv-1 tat interactive protein 1, homolog (human)

Mouse chromosome position	19

OMIM ID	601409

Rat chromosome position	1q43

Hugo ID	5275

Human chromosome position	11q13

EC Number	2.3.1.48

Homologene ID	100661

MGI ID	1932051

RGD ID	621061

MedScan ID	10524

Primary Cell Localization	Nucleus