| URN | urn:agi-llid:3014 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1242 |
| Name | H2AFX |
| Description | H2A histone family, member X |
| Notes | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | histone binding |
|---|---|
| enzyme binding | |
| protein heterodimerization activity | |
| DNA binding | |
| damaged DNA binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| condensed nuclear chromosome | |
| nuclear chromatin | |
| replication fork | |
| site of double-strand break | |
| chromosome, telomeric region | |
| chromatin | |
| nucleosome | |
| chromosome | |
| XY body | |
| nucleus | |
| male germ cell nucleus |
| GO Biological Process | meiotic nuclear division |
|---|---|
| spermatogenesis | |
| DNA repair | |
| positive regulation of DNA repair | |
| double-strand break repair | |
| double-strand break repair via homologous recombination | |
| cell cycle | |
| DNA damage checkpoint | |
| cellular response to DNA damage stimulus | |
| response to ionizing radiation | |
| DNA recombination | |
| nucleosome assembly |
| Pathway | INO80 Chromatin Remodeling |
|---|---|
| TRRAP/TIP60 Chromatin Remodeling | |
| Histone Phosphorylation | |
| Cell Cycle | |
| Double Strand DNA Homologous Repair | |
| Double Strand DNA Non-Homologous Repair | |
| Immunoglobulin Class-Switch Recombination via Alternative End-Joining | |
| Immunoglobulin Class-Switch Recombination via Classical Non-Homologous End-Joining | |
| ataxia telangiectasia-mutated (ATM) signaling pathway | |
| Copy of 'ataxia telangiectasia-mutated (ATM) signaling pathway' |
| Group | Chromatin remodeling |
|---|---|
| meiotic nuclear division | |
| spermatogenesis | |
| DNA repair | |
| positive regulation of DNA repair | |
| double-strand break repair | |
| double-strand break repair via homologous recombination | |
| cell cycle | |
| DNA damage checkpoint | |
| cellular response to DNA damage stimulus | |
| response to ionizing radiation | |
| DNA recombination | |
| nucleosome assembly | |
| histone binding | |
| enzyme binding | |
| protein heterodimerization activity | |
| DNA binding | |
| damaged DNA binding | |
| nucleoplasm | |
| condensed nuclear chromosome | |
| nuclear chromatin | |
| replication fork | |
| site of double-strand break | |
| chromosome, telomeric region | |
| chromatin | |
| nucleosome | |
| chromosome | |
| XY body | |
| nucleus | |
| male germ cell nucleus | |
| Genes with Mutations Associated with Breast Cancer | |
| Basic Regulators of Immunoglobulin Class-Switch Recombination | |
| Basic Regulators of Alternative End Joining | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 3014 |
|---|---|
| 15270 | |
| 500987 |
| Cell Localization | Nucleus |
|---|---|
| Chromosome |
| GO ID | 0003677 |
|---|---|
| 0003684 | |
| 0019899 | |
| 0042393 | |
| 0046982 | |
| 0000077 | |
| 0006281 | |
| 0006974 | |
| 0006302 | |
| 0000724 | |
| 0007126 | |
| 0006334 | |
| 0045739 | |
| 0010212 | |
| 0007283 | |
| 0001741 | |
| 0000781 | |
| 0000794 | |
| 0001673 | |
| 0000790 | |
| 0005654 | |
| 0000786 | |
| 0005634 | |
| 0005657 | |
| 0006310 | |
| 0007049 | |
| 0000785 | |
| 0005694 | |
| 0035861 |
| Alias | H2AX |
|---|---|
| H2A.X | |
| H2A/X | |
| histone H2AX | |
| H2AX histone | |
| histone H2A.x | |
| AW228881 | |
| Hist5-2ax | |
| gammaH2ax | |
| histone 5 protein 2ax | |
| RGD1566119 | |
| H2A histone family, member X | |
| histone 2ax | |
| LOC115272 | |
| histone family H2A, member X | |
| histone 5 2ax | |
| H2afx | |
| histone 2a.x |
| Mouse chromosome position | 9 24.84 cM |
|---|---|
| 9 26.0 cM |
| OMIM ID | 601772 |
|---|
| Rat chromosome position | 8q22 |
|---|
| Hugo ID | 4739 |
|---|
| Human chromosome position | 11q23.3 |
|---|
| Swiss-Prot Accession | P16104 |
|---|---|
| P27661 | |
| D3ZXP3 | |
| Q4ZGJ7 | |
| Q6IAS5 |
| PIR ID | S07631 |
|---|---|
| I48406 |
| Unigene ID | Hs.477879 |
|---|---|
| Mm.245931 | |
| Rn.2850 |
| KEGG ID | hsa:3014 |
|---|---|
| mmu:15270 | |
| rno:500987 |
| Swiss-Prot ID | H2AX_HUMAN |
|---|---|
| H2AX_MOUSE |
| Ensembl ID | ENSG00000188486 |
|---|---|
| ENSP00000434024 | |
| ENST00000530167 | |
| ENSMUSG00000049932 | |
| ENSMUSP00000051432 | |
| ENSMUST00000052686 | |
| ENSRNOG00000010386 | |
| ENSRNOP00000056469 | |
| ENSRNOT00000059715 |
| Homologene ID | 115922 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 102688 |
|---|
| RGD ID | 1566119 |
|---|
| MedScan ID | 3014 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| IPI ID | IPI00230264 |
|---|---|
| IPI00219037 |