Protein RBBP8

URN	urn:agi-llid:5932
Total Entities	0
Connectivity	194
Name	RBBP8
Description	retinoblastoma binding protein 8
Notes	The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

GO Molecular Function	RNA polymerase II transcription corepressor activity
	hydrolase activity
	nuclease activity
	endonuclease activity
	single-stranded DNA endodeoxyribonuclease activity
	RNA polymerase II repressing transcription factor binding
	DNA binding
	damaged DNA binding

GO Cellular Component	transcriptional repressor complex
	nucleus

GO Biological Process	meiotic nuclear division
	DNA repair
	double-strand break repair via homologous recombination
	DNA double-strand break processing involved in repair via single-strand annealing
	blastocyst hatching
	cell division
	cell cycle
	mitosis
	cell cycle checkpoint
	G2 DNA damage checkpoint
	G1-S transition of mitotic cell cycle
	cellular response to DNA damage stimulus
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription from RNA polymerase II promoter
	transcription from RNA polymerase II promoter
	DNA catabolic process, endonucleolytic

Pathway	Double Strand DNA Homologous Repair
	Immunoglobulin Class-Switch Recombination via Alternative End-Joining
	ataxia telangiectasia-mutated (ATM) signaling pathway
	homologous recombination pathway of double-strand break repair
	Copy of 'ataxia telangiectasia-mutated (ATM) signaling pathway'

Group	Transcription factors
	meiotic nuclear division
	DNA repair
	double-strand break repair via homologous recombination
	DNA double-strand break processing involved in repair via single-strand annealing
	blastocyst hatching
	cell division
	cell cycle
	mitosis
	cell cycle checkpoint
	G2 DNA damage checkpoint
	G1-S transition of mitotic cell cycle
	cellular response to DNA damage stimulus
	negative regulation of transcription from RNA polymerase II promoter
	RNA polymerase II transcription corepressor activity
	regulation of transcription from RNA polymerase II promoter
	hydrolase activity
	nuclease activity
	endonuclease activity
	single-stranded DNA endodeoxyribonuclease activity
	transcription from RNA polymerase II promoter
	DNA catabolic process, endonucleolytic
	RNA polymerase II repressing transcription factor binding
	DNA binding
	damaged DNA binding
	transcriptional repressor complex
	nucleus
	Genes with Mutations Associated with Ovarian Cancer
	Proteins Involved in Pathogenesis of Hereditary Breast and Ovarian Cancer Syndrome
	Basic Regulators of Immunoglobulin Class-Switch Recombination
	Basic Regulators of Alternative End Joining

Cell Localization	Nucleus

Alias	RIM
	COM1
	CTIP
	JWDS
	SAE2
	SCKL2
	DNA endonuclease RBBP8
	RBBP-8
	CTBP-interacting protein
	sporulation in the absence of SPO11 protein 2 homolog
	9930104E21Rik
	retinoblastoma-binding protein 8
	RGD1308872
	rCG_41266
	C-terminal binding protein interacting protein
	CtBP-interactive protein
	CtBP interacting protein
	Seckel syndrome 2
	Retinoblastoma-interactive protein and myosin-like
	RBBP8
	CtBP interactive protein
	retinoblastoma binding protein 8
	HGCN
	OTTHUMP00000162575
	9930104E21
	retinoblastoma binding protein VIII
	retinoblastoma-interacting myosin-like
	Retinoblastoma-interacting protein and myosin-like
	retinoblastoma-interactive myosin-like
	CTBP-interactive protein CtIP
	CTBP-interacting protein CtIP

Mouse chromosome position	18

Rat chromosome position	18p13

Hugo ID	9891

Human chromosome position	18q11.2

EC Number	3.1.-.-

Homologene ID	28546

MGI ID	2442995

RGD ID	1308872

MedScan ID	5932
	347729