| URN | urn:agi-llid:93765 |
|---|---|
| Total Entities | 0 |
| Connectivity | 0 |
| Name | Ube2n |
| Description | ubiquitin-conjugating enzyme E2N |
| Notes | mediates ubiquitin-dependent proteolytic pathway; forms a thiolester linkage between the active site cysteine and the ubiquitin, supports conjunction with a third protein, ubiquitin-protein ligase (E3) [RGD, Feb 2006] |
| GO Molecular Function | ubiquitin binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| ligase activity | |
| acid-amino acid ligase activity | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | ubiquitin ligase complex |
|---|---|
| UBC13-MMS2 complex | |
| UBC13-UEV1A complex | |
| cytoplasm | |
| nucleus |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| T cell receptor signaling pathway | |
| positive regulation of DNA repair | |
| positive regulation of histone modification | |
| positive regulation of ubiquitin-protein ligase activity | |
| regulation of histone ubiquitination | |
| positive regulation of NF-kappaB transcription factor activity | |
| DNA double-strand break processing | |
| DNA repair | |
| postreplication repair | |
| double-strand break repair via homologous recombination | |
| histone ubiquitination | |
| protein ubiquitination | |
| protein K63-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus |
| Pathway | ataxia telangiectasia-mutated (ATM) signaling pathway |
|---|
| Group | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| T cell receptor signaling pathway | |
| positive regulation of DNA repair | |
| positive regulation of histone modification | |
| positive regulation of ubiquitin-protein ligase activity | |
| regulation of histone ubiquitination | |
| positive regulation of NF-kappaB transcription factor activity | |
| DNA double-strand break processing | |
| DNA repair | |
| postreplication repair | |
| double-strand break repair via homologous recombination | |
| histone ubiquitination | |
| protein ubiquitination | |
| protein K63-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| ubiquitin binding | |
| nucleotide binding | |
| ATP binding | |
| ligase activity | |
| acid-amino acid ligase activity | |
| ubiquitin-protein ligase activity | |
| ubiquitin ligase complex | |
| UBC13-MMS2 complex | |
| UBC13-UEV1A complex | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 93765 |
|---|---|
| 116725 |
| Alias | UBC13 |
|---|---|
| AL022654 | |
| BB101821 | |
| 1500026J17Rik | |
| ubiquitin-conjugating enzyme E2 N | |
| ubiquitin-protein ligase N | |
| ubiquitin carrier protein N | |
| bendless-like ubiquitin-conjugating enzyme | |
| bendless protein | |
| ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | |
| ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) | |
| Blu |
| Organism | Mus musculus |
|---|---|
| Rattus norvegicus |
| Unigene ID | Mm.371667 |
|---|---|
| Mm.440187 | |
| Mm.486592 | |
| Rn.230134 |
| KEGG ID | mmu:93765 |
|---|---|
| rno:116725 |
| Swiss-Prot Accession | A2RTT4 |
|---|---|
| P61089 | |
| Q9EQX9 | |
| Q16781 | |
| Q3TSL6 | |
| Q6ZWZ0 | |
| Q9DAJ6 |
| EC Number | 6.3.2.19 |
|---|
| GO ID | 0005524 |
|---|---|
| 0016881 | |
| 0016874 | |
| 0000166 | |
| 0043130 | |
| 0004842 | |
| 0000729 | |
| 0006281 | |
| 0050852 | |
| 0000724 | |
| 0016574 | |
| 0045739 | |
| 0043123 | |
| 0051092 | |
| 0031058 | |
| 0051443 | |
| 0006301 | |
| 0070534 | |
| 0016567 | |
| 0033182 | |
| 0006974 | |
| 0006511 | |
| 0031372 | |
| 0035370 | |
| 0005737 | |
| 0005634 | |
| 0000151 |
| Swiss-Prot ID | UBE2N_MOUSE |
|---|---|
| UBE2N_RAT |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00165854 |
|---|---|
| IPI00190559 |
| Mouse chromosome position | 10 |
|---|
| Rat chromosome position | 7q13 |
|---|
| Homologene ID | 128406 |
|---|
| MGI ID | 1934835 |
|---|
| RGD ID | 621096 |
|---|