| URN | urn:agi-llid:9656 |
|---|---|
| Total Entities | 0 |
| Connectivity | 221 |
| Name | MDC1 |
| Description | mediator of DNA-damage checkpoint 1 |
| Notes | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | protein C-terminus binding |
|---|---|
| FHA domain binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| chromosome | |
| nucleus | |
| focal adhesion |
| GO Biological Process | DNA repair |
|---|---|
| double-strand break repair | |
| double-strand break repair via homologous recombination | |
| cell cycle | |
| intra-S DNA damage checkpoint | |
| cellular response to DNA damage stimulus |
| Pathway | Double Strand DNA Homologous Repair |
|---|---|
| Nuclear EGFR | |
| Immunoglobulin Class-Switch Recombination via Alternative End-Joining | |
| Immunoglobulin Class-Switch Recombination via Classical Non-Homologous End-Joining | |
| ataxia telangiectasia-mutated (ATM) signaling pathway | |
| Copy of 'ataxia telangiectasia-mutated (ATM) signaling pathway' |
| Group | DNA repair |
|---|---|
| double-strand break repair | |
| double-strand break repair via homologous recombination | |
| cell cycle | |
| intra-S DNA damage checkpoint | |
| cellular response to DNA damage stimulus | |
| protein C-terminus binding | |
| FHA domain binding | |
| nucleoplasm | |
| nucleolus | |
| chromosome | |
| nucleus | |
| focal adhesion | |
| Basic Regulators of Immunoglobulin Class-Switch Recombination | |
| Basic Regulators of Alternative End Joining | |
| Biofluids assayable substances |
| LocusLink ID | 9656 |
|---|---|
| 240087 | |
| 309595 |
| Cell Localization | Nucleus |
|---|---|
| Chromosome |
| GO ID | 0070975 |
|---|---|
| 0008022 | |
| 0006281 | |
| 0006302 | |
| 0000724 | |
| 0031573 | |
| 0005694 | |
| 0005925 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0007049 | |
| 0006974 |
| Alias | NFBD1 |
|---|---|
| DAAP-285E11.7 | |
| mediator of DNA damage checkpoint protein 1 | |
| nuclear factor with BRCT domains 1 | |
| mediator of DNA damage checkpoint 1 | |
| homologue to Drosophila photoreceptor protein calphotin | |
| AA413496 | |
| mKIAA0170 | |
| 6820401C03 | |
| mediation of DNA damage checkpoint 1 | |
| Kiaa0170 | |
| mediation of dna damage checkpoint I | |
| mediator of dna damage checkpoint I | |
| NFBD I | |
| nuclear factor with brct domians protein 1 | |
| OTTHUMP00000029090 | |
| nuclear factor with brct domians protein I | |
| DKFZp781A0122 | |
| Em:AB023051.5 | |
| MDC I | |
| MGC166888 | |
| MDC1 |
| Mouse chromosome position | 17 |
|---|
| OMIM ID | 607593 |
|---|
| Rat chromosome position | 20p12 |
|---|
| Hugo ID | 21163 |
|---|
| Human chromosome position | 6p21.3 |
|---|
| Swiss-Prot Accession | A1Z5I9 |
|---|---|
| Q14676 | |
| E9QK89 | |
| Q5PSV9 | |
| Q5U2M8 | |
| A2AB04 | |
| A2BF04 | |
| A2RRA8 | |
| A7YY86 | |
| B0S8A2 | |
| Q0EFC2 | |
| Q2L6H7 | |
| Q2TAZ4 | |
| Q5JP55 | |
| Q5JP56 | |
| Q5ST83 | |
| Q68CQ3 | |
| Q86Z06 | |
| Q96QC2 | |
| Q52KG1 | |
| Q5U4D3 | |
| Q6ZQH7 | |
| Q6MG15 |
| Unigene ID | Hs.653495 |
|---|---|
| Mm.218511 | |
| Rn.106312 |
| KEGG ID | hsa:9656 |
|---|---|
| mmu:240087 | |
| rno:309595 |
| Swiss-Prot ID | MDC1_HUMAN |
|---|---|
| MDC1_MOUSE | |
| MDC1_RAT |
| Ensembl ID | ENSG00000137337 |
|---|---|
| ENSP00000365588 | |
| ENST00000376406 | |
| ENSP00000365587 | |
| ENST00000376405 | |
| ENSMUSG00000061607 | |
| ENSMUSP00000080949 | |
| ENSMUST00000082337 | |
| ENSRNOG00000032813 | |
| ENSRNOP00000049009 | |
| ENSRNOT00000046798 |
| Homologene ID | 67092 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 3525201 |
|---|
| RGD ID | 1559468 |
|---|
| MedScan ID | 9656 |
|---|---|
| 309595 |
| IPI ID | IPI01007763 |
|---|---|
| IPI00953795 | |
| IPI00470805 | |
| IPI00552897 | |
| IPI00895842 | |
| IPI00895860 |