| URN | urn:agi-llid:9810 |
|---|---|
| Total Entities | 0 |
| Connectivity | 43 |
| Name | Rnf40 |
| Description | ring finger protein 40, E3 ubiquitin protein ligase |
| Notes | The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| Ariadne Ontology | Ubiquitin-dependent protein degradation |
|---|
| GO Molecular Function | protein complex binding |
|---|---|
| syntaxin-1 binding | |
| ubiquitin protein ligase binding | |
| protein homodimerization activity | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | nucleolus |
|---|---|
| HULC complex | |
| protein complex | |
| ubiquitin ligase complex | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| neuron projection |
| GO Biological Process | histone monoubiquitination |
|---|---|
| histone H2B ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| chromatin modification |
| Pathway | ataxia telangiectasia-mutated (ATM) signaling pathway |
|---|
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| histone monoubiquitination | |
| histone H2B ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| chromatin modification | |
| protein complex binding | |
| syntaxin-1 binding | |
| ubiquitin protein ligase binding | |
| protein homodimerization activity | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| nucleolus | |
| HULC complex | |
| protein complex | |
| ubiquitin ligase complex | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| neuron projection |
| MedScan ID | 9810 |
|---|
| Hugo ID | 16867 |
|---|
| Human chromosome position | 16p11.2-p11.1 |
|---|
| LocusLink ID | 9810 |
|---|---|
| 233900 | |
| 266712 |
| Alias | BRE1B |
|---|---|
| RBP95 | |
| STARING | |
| E3 ubiquitin-protein ligase BRE1B | |
| BRE1-B | |
| Rb-associated protein | |
| BRE1 E3 ubiquitin ligase homolog B | |
| 95 kDa retinoblastoma-associated protein | |
| 95 kDa retinoblastoma protein binding protein | |
| AI848422 | |
| mKIAA0661 | |
| protein staring | |
| staring protein | |
| syntaxin-1-interacting RING finger protein | |
| Kiaa0661 | |
| Rb associated protein | |
| RING finger protein 40 | |
| RNF40 | |
| likely ortholog of rat staring | |
| MGC19037 | |
| DKFZp686k191 | |
| LOC233900 | |
| MGC13051 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607700 |
|---|
| Unigene ID | Hs.65238 |
|---|---|
| Mm.41122 | |
| Rn.162466 |
| KEGG ID | hsa:9810 |
|---|---|
| mmu:233900 | |
| rno:266712 |
| Swiss-Prot Accession | A8K6K1 |
|---|---|
| O75150 | |
| Q3U319 | |
| Q8CJB9 | |
| Q6ZQ75 | |
| Q8BJA1 | |
| Q8BY03 | |
| Q8CHX4 | |
| Q6AHZ6 | |
| Q6N005 | |
| Q7L3T6 | |
| Q8N615 | |
| Q96T18 | |
| Q9BSV9 | |
| Q9HC82 |
| EC Number | 6.3.2.- |
|---|
| GO ID | 0032403 |
|---|---|
| 0042803 | |
| 0017075 | |
| 0031625 | |
| 0004842 | |
| 0008270 | |
| 0033523 | |
| 0010390 | |
| 0006511 | |
| 0033503 | |
| 0005737 | |
| 0043005 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0000151 | |
| 0016874 | |
| 0046872 | |
| 0016568 | |
| 0043234 |
| PIR ID | JC7363 |
|---|
| Swiss-Prot ID | BRE1B_MOUSE |
|---|---|
| BRE1B_HUMAN | |
| BRE1B_RAT |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00621791 |
|---|---|
| IPI00162563 | |
| IPI00290648 | |
| IPI00377273 | |
| IPI00194637 |
| Mouse chromosome position | 7 |
|---|
| Rat chromosome position | 1q36 |
|---|
| Homologene ID | 8856 |
|---|
| MGI ID | 2142048 |
|---|
| RGD ID | 628638 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|