| URN | urn:agi-llid:165918 |
|---|---|
| Total Entities | 0 |
| Connectivity | 61 |
| Name | Rnf168 |
| Description | ring finger protein 168, E3 ubiquitin protein ligase |
| Notes | This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011] |
| GO Molecular Function | chromatin binding |
|---|---|
| histone binding | |
| ubiquitin binding | |
| K63-linked polyubiquitin binding | |
| nucleosome binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | site of double-strand break |
|---|---|
| ubiquitin ligase complex | |
| nucleus |
| GO Biological Process | positive regulation of DNA repair |
|---|---|
| negative regulation of translational elongation | |
| isotype switching | |
| DNA repair | |
| interstrand cross-link repair | |
| double-strand break repair | |
| histone H2A monoubiquitination | |
| histone H2A K63-linked ubiquitination | |
| histone H2A-K13 ubiquitination | |
| histone H2A-K15 ubiquitination | |
| protein ubiquitination | |
| protein K63-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| chromatin modification | |
| response to ionizing radiation |
| Pathway | ataxia telangiectasia-mutated (ATM) signaling pathway |
|---|
| Group | positive regulation of DNA repair |
|---|---|
| negative regulation of translational elongation | |
| isotype switching | |
| DNA repair | |
| interstrand cross-link repair | |
| double-strand break repair | |
| histone H2A monoubiquitination | |
| histone H2A K63-linked ubiquitination | |
| histone H2A-K13 ubiquitination | |
| histone H2A-K15 ubiquitination | |
| protein ubiquitination | |
| protein K63-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| chromatin modification | |
| response to ionizing radiation | |
| chromatin binding | |
| histone binding | |
| ubiquitin binding | |
| K63-linked polyubiquitin binding | |
| nucleosome binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| site of double-strand break | |
| ubiquitin ligase complex | |
| nucleus |
| MedScan ID | 165918 |
|---|---|
| 614360 |
| Hugo ID | 26661 |
|---|
| Human chromosome position | 3q29 |
|---|
| LocusLink ID | 165918 |
|---|---|
| 70238 | |
| 690043 | |
| 684436 |
| Alias | hRNF168 |
|---|---|
| E3 ubiquitin-protein ligase RNF168 | |
| 3110001H15Rik | |
| ring fnger protein 168 | |
| rnf168 | |
| RING finger protein 168 | |
| 3110001H15 | |
| FLJ35794 | |
| MGC188789 | |
| LOC684436 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 612688 |
|---|---|
| 611943 |
| Unigene ID | Hs.250648 |
|---|---|
| Mm.228263 | |
| Rn.101441 |
| KEGG ID | hsa:165918 |
|---|---|
| mmu:70238 | |
| rno:690043 |
| Swiss-Prot Accession | Q8IYW5 |
|---|---|
| E9PYW4 | |
| Q80XJ2 | |
| B2RYR0 | |
| Q8NA67 | |
| Q96NS4 |
| EC Number | 6.3.2.- |
|---|
| GO ID | 0070530 |
|---|---|
| 0003682 | |
| 0042393 | |
| 0031491 | |
| 0043130 | |
| 0004842 | |
| 0008270 | |
| 0006302 | |
| 0070535 | |
| 0035518 | |
| 0036351 | |
| 0036352 | |
| 0036297 | |
| 0045190 | |
| 0045900 | |
| 0045739 | |
| 0070534 | |
| 0016567 | |
| 0006974 | |
| 0010212 | |
| 0006511 | |
| 0005634 | |
| 0035861 | |
| 0000151 | |
| 0016874 | |
| 0046872 | |
| 0006281 | |
| 0016568 |
| Swiss-Prot ID | RN168_RAT |
|---|---|
| RN168_MOUSE | |
| RN168_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00764042 |
|---|---|
| IPI00330736 | |
| IPI00217899 |
| Mouse chromosome position | 16 |
|---|
| Rat chromosome position | 11q22 |
|---|
| Homologene ID | 87044 |
|---|
| MGI ID | 1917488 |
|---|
| RGD ID | 1585168 |
|---|