| URN | urn:agi-llid:7508 |
|---|---|
| Connectivity | 89 |
| Name | Xpc |
| Description | xeroderma pigmentosum, complementation group C |
| Notes | This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|---|
| altered nucleotide excision repair pathway |
| GO Molecular Function | DNA binding |
|---|---|
| damaged DNA binding | |
| single-stranded DNA binding |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleoplasm | |
| nucleus |
| GO Biological Process | cell cycle checkpoint |
|---|---|
| intra-S DNA damage checkpoint | |
| DNA repair | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| response to DNA damage stimulus | |
| response to drug | |
| response to UV-B |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| cell cycle checkpoint | |
| intra-S DNA damage checkpoint | |
| DNA repair | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| response to DNA damage stimulus | |
| response to drug | |
| response to UV-B | |
| DNA binding | |
| damaged DNA binding | |
| single-stranded DNA binding | |
| cytoplasm | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 7508 |
|---|
| Hugo ID | 12816 |
|---|
| Human chromosome position | 3p25 |
|---|
| LocusLink ID | 7508 |
|---|---|
| 22591 | |
| 312560 |
| Alias | XP3 |
|---|---|
| RAD4 | |
| XPCC | |
| DNA repair protein complementing XP-C cells | |
| p125 | |
| DNA repair protein complementing XP-C cells homolog | |
| OTTMUSP00000028684 | |
| xeroderma pigmentosum group C-complementing protein homolog | |
| xeroderma pigmentosum, complementation group C | |
| DNA-repair protein complementing XP-C cells | |
| Xeroderma pigmentosum group C complementing protein | |
| xeroderma pigmentosum group c protein | |
| xeroderma pigmentosum, complementing group C | |
| XPC |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 613208 |
|---|---|
| 278720 |
| Mouse chromosome position | 6 |
|---|
| GO ID | 0003684 |
|---|---|
| 0003697 | |
| 0006281 | |
| 0000075 | |
| 0031573 | |
| 0006289 | |
| 0000718 | |
| 0010224 | |
| 0005654 | |
| 0005634 | |
| 0003677 | |
| 0006974 | |
| 0005737 | |
| 0042493 |
| Rat chromosome position | 4q34 |
|---|
| Swiss-Prot Accession | B4DIP3 |
|---|---|
| Q01831 | |
| P51612 | |
| Q7TSZ1 | |
| Q53GT7 | |
| Q96AX0 | |
| P54732 | |
| Q3TKI2 | |
| Q920M1 | |
| Q9DBW7 |
| PIR ID | S44345 |
|---|---|
| S70630 |
| Unigene ID | Hs.475538 |
|---|---|
| Mm.2806 | |
| Rn.22820 |
| KEGG ID | hsa:7508 |
|---|---|
| mmu:22591 | |
| rno:312560 |
| Swiss-Prot ID | XPC_HUMAN |
|---|---|
| XPC_MOUSE | |
| B4DIP3_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00156793 |
|---|---|
| IPI00124885 | |
| IPI00924991 | |
| IPI00794652 | |
| IPI00475584 | |
| IPI00365175 |
| Homologene ID | 3401 |
|---|
| RGD ID | 1305760 |
|---|
| MGI ID | 103557 |
|---|